Target's General Information
Target ID T05938
Target Name Ovarian carcinoma antigen CA125 (MUC16)
Synonyms Ovarian cancerrelated tumor marker CA125; Mucin16; MUC16; CA125
Target Type Clinical trial
Gene Name MUC16
Biochemical Class Mucin
UniProt ID MUC16_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Ovarian cancer
Example drug Oregovomab Phase 3 [1], [2], [3]
Tissue Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 5.02
Z-score: 2.6
P-value: 4.86E-04
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 1.61
Z-score: 0.7
P-value: 1.62E-03
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress. Mol Cancer. 2014; 13: 129.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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