Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T15439 | ||||
| Target Name | C5a anaphylatoxin chemotactic receptor (C5AR1) | ||||
| Synonyms | CD88; C5aR; C5a-R; C5a anaphylatoxin chemotactic receptor 1; C5R1 | ||||
| Target Type | Successful | ||||
| Gene Name | C5AR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | C5AR1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Rheumatoid arthritis | ||||
| Example drug | NN8209 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 1.19 Z-score: 0.77 P-value: 3.99E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Atopic dermatitis | ||||
| Tissue | Skin | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.29 Z-score: 0.87 P-value: 2.34E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022053) | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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