Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T16016 | ||||
| Target Name | C-C chemokine receptor type 1 (CCR1) | ||||
| Synonyms | SCYAR1; RANTES-R; Macrophage inflammatory protein-1 alpha receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; LD78 receptor; HM145; Chemokine receptor CCR1; CMKR1; CMKBR1; CD191; CCR-1; CC-CKR-1; C-C CKR-1 | ||||
| Target Type | Clinical trial | ||||
| Gene Name | CCR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | CCR1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | AZD4818 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.11 Z-score: 0.22 P-value: 3.93E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | AZD4818 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Small airway epithelium | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.54 Z-score: 0.68 P-value: 2.85E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Rheumatoid arthritis | ||||
| Example drug | BMS-817399 | Phase 2 | [2], [3], [4] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.2 Z-score: -0.18 P-value: 4.90E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025769) | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | ClinicalTrials.gov (NCT01404585) Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis. U.S. National Institutes of Health. | ||||
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