Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T16688 | ||||
| Target Name | Diacylglycerol acyltransferase 1 (DGAT1) | ||||
| Synonyms | Retinol O-fatty-acyltransferase; Diglyceride acyltransferase; Diacylglycerol O-acyltransferase 1; DGAT; Acyl-CoA retinol O-fatty-acyltransferase; ARAT; AGRP1; ACAT-related gene product 1 | ||||
| Target Type | Successful | ||||
| Gene Name | DGAT1 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | DGAT1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Type 2 diabetes | ||||
| Example drug | PF-04620110 | Terminated | [1], [2], [3] | ||
| Tissue | Liver tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.41 Z-score: -0.62 P-value: 3.51E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| References | |||||
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7829). | ||||
| REF 2 | Clinical pipeline report, company report or official report of Pfizer (2011). | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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