Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T28226 | ||||
| Target Name | GTP cyclohydrolase-I (GCH1) | ||||
| Synonyms | Guanosine triphosphate cyclohydrolase I; GTP-CH-I; GTP cyclohydrolase I; GTP cyclohydrolase 1; GCH; DYT5 | ||||
| Target Type | Clinical trial | ||||
| Gene Name | GCH1 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | GCH1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Parkinson's disease | ||||
| Example drug | ProSavin | Phase 1/2 | [1], [2], [3] | ||
| Tissue | Substantia nigra tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -1.59 Z-score: -1.53 P-value: 3.38E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01856439) Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease. U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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