Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T29754 | ||||
| Target Name | MAPK-activated protein kinase 5 (MAPKAPK5) | ||||
| Synonyms | p38regulated/activated protein kinase; p38-regulated/activated protein kinase; PRAK; MK5; MK-5; MAPKactivated protein kinase 5; MAPKAPK-5; MAPKAP-K5; MAPKAP kinase 5; MAP kinaseactivated protein kinase 5; MAP kinase-activated protein kinase 5 | ||||
| Target Type | Discontinued | ||||
| Gene Name | MAPKAPK5 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | MAPK5_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Rheumatoid arthritis | ||||
| Example drug | GLPG-0259 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.87 Z-score: 1.37 P-value: 5.33E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Clinical pipeline report, company report or official report of Galapagos. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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