Target's General Information
Target ID T36059
Target Name Adenosine A3 receptor (ADORA3)
Synonyms Adenosine receptor A3A; Adenosine receptor A3; Adenosine 3 receptor; A3AR; A3 Adenosine receptor
Target Type Clinical trial
Gene Name ADORA3
Biochemical Class GPCR rhodopsin
UniProt ID AA3R_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Multiple sclerosis
Example drug METHYLTHIOADENOSINE Terminated [1], [2], [3]
Tissue Spinal cord
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 0.95
Z-score: 0.88
P-value: 6.10E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Disease Liver cancer
Example drug CF102 Phase 1/2 [2], [3], [4]
Tissue Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.73
Z-score: -1.4
P-value: 6.30E-08
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: -0.97
Z-score: -1.52
P-value: 1.35E-37
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Disease Asthma
Tissue Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.28
Z-score: 0.71
P-value: 1.35E-12
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000987)
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.
REF 4 2011 Pipeline of Can-Fite BioPharm.

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