Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T56545 | ||||
| Target Name | Apolipoprotein A-I (APOA1) | ||||
| Synonyms | Truncated apolipoprotein AI; Apolipoprotein A1; ApoAI; ApoA-I; Apo-AI | ||||
| Target Type | Clinical trial | ||||
| Gene Name | APOA1 | ||||
| Biochemical Class | Apolipoprotein | ||||
| UniProt ID | APOA1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Coronary artery disease | ||||
| Example drug | CSL-112 | Phase 2 | [1], [2], [3] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.03 Z-score: -0.45 P-value: 8.72E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Aortic stenosis | ||||
| Example drug | CER-522 | Phase 1 | [2], [3], [4] | ||
| Tissue | Calcified aortic valve | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.25 Z-score: -0.24 P-value: 2.95E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Arteriosclerosis | ||||
| Example drug | MDCO-216 | Phase 1 | [2], [3], [5] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.17 Z-score: 1.01 P-value: 1.44E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02108262) A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.. U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033541) | ||||
| REF 5 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012886) | ||||
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