Target expression details

Target's General Information
Target ID T60857
Target Name Dihydrodiol dehydrogenase type I (AKR1C3)
Synonyms Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Testosterone 17-beta-dehydrogenase 5; Prostaglandin F synthase; PGFS; KIAA0119; Indanol dehydrogenase; HSD17B5; HA1753; Dihydrodiol dehydrogenase 3; DDH1; DD3; DD-3; Chlordecone reductase homolog HAKRb; Aldo-keto reductase family 1 member C3; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type II, brain; 3-alpha-HSD type 2; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5
Target Type Successful
Gene Name AKR1C3
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID AK1C3_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Prostate cancer
Example drug ASP-9521 Phase 1/2 [1], [2], [3]
Tissue Prostate
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.39
Z-score: 0.74
P-value: 4.06E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
Download the Expression Profile
References
REF 1 ClinicalTrials.gov (NCT01352208) Phase I/II Study of ASP9521 in Castrate-Resistant Prostate Cancer (CRPC) Patients. U.S. National Institutes of Health.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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