Target's General Information
Target ID T69685
Target Name Glycine transporter GlyT-1 (SLC6A9)
Synonyms Solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1; Glycine type-1 transporter; Glycine transporter type 1; GlyT1; GlyT-1
Target Type Clinical trial
Gene Name SLC6A9
Biochemical Class Neurotransmitter:sodium symporter
UniProt ID SC6A9_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Schizophrenia
Example drug R1678 Phase 3 [1], [2], [3], [4]
Tissue Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.09
Z-score: -0.34
P-value: 4.94E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Schizophrenia
Example drug R1678 Phase 3 [1], [2], [3], [4]
Tissue Superior temporal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.03
Z-score: -0.17
P-value: 1.64E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7546).
REF 2 ClinicalTrials.gov (NCT01235559) A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25305). U.S. National Institutes of Health.
REF 3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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