Target's General Information
Target ID T77796
Target Name Thyrotropin-releasing hormone receptor (TRHR)
Synonyms Thyroliberin receptor; TRH-R
Target Type Successful
Gene Name TRHR
Biochemical Class GPCR rhodopsin
UniProt ID TRFR_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Parkinson's disease
Example drug Posatirelin Discontinued in Phase 3 [1], [2], [3]
Tissue Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.11
Z-score: 0.61
P-value: 2.98E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005568)
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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