Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T94479 | ||||
| Target Name | Ribosomal protein S6 kinase beta-1 (S6K1) | ||||
| Synonyms | p70-S6K 1; p70 ribosomal S6 kinase alpha; p70 S6KA; p70 S6K-alpha; p70 S6 kinase alpha; Serine/threonine-protein kinase 14A; STK14A; S6K-beta-1; S6K; Ribosomal protein S6 kinase I; P70S6K1; P70-S6K; 70 kDa ribosomal protein S6 kinase 1 | ||||
| Target Type | Clinical trial | ||||
| Gene Name | RPS6KB1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | KS6A1_HUMAN||KS6A2_HUMAN||KS6A3_HUMAN||KS6A4_HUMAN||KS6A5_HUMAN||KS6A6_HUMAN||KS6B1_HUMAN||KS6B2_HUMAN||KS6C1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Ulcerative colitis | ||||
| Example drug | PF-4708671 | Clinical trial | [1], [2], [3] | ||
| Tissue | Colon mucosal tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: 0.03 Z-score: 0.07 P-value: 4.83E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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