Target's General Information
Target ID T97196
Target Name ATM serine/threonine kinase (ATM)
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Target Type Clinical trial
Gene Name ATM
Biochemical Class Kinase
UniProt ID ATM_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Lung cancer
Example drug KU-60019 Clinical trial [1], [2], [3]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.01
Z-score: -0.02
P-value: 8.10E-01
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 0.19
Z-score: 0.45
P-value: 4.91E-05
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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