miRNA General Information
miRNA Mature ID hsa-let-7g-5p
miRNA Stemloop AC MI0000433
miRNA Stemloop ID hsa-let-7g
Sequence ugagguaguaguuuguacaguu
TTD Target(s) Regulated by This miRNA TGF-beta receptor type I (TGFBR1) Clinical trial Target Target Info [1]
Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target Target Info [2]
Caspase-3 (CASP3) Clinical trial Target Target Info [3]
Fibronectin (FN1) Clinical trial Target Target Info [4]
Interleukin-13 (IL13) Successful Target Target Info [5]
TRAIL receptor 2 (TRAIL-R2) Clinical trial Target Target Info [6]
Collagen I (COL1A2) Clinical trial Target Target Info [7]
Thrombospondin-1 (THBS1) Clinical trial Target Target Info [1]
Proto-oncogene c-Myc (MYC) Literature-reported Target Target Info [8]
RAC-beta serine/threonine-protein kinase (AKT2) Literature-reported Target Target Info [9]
Epithelial discoidin domain receptor 1 (DDR1) Patented-recorded Target Target Info [10]
Polycomb complex protein BMI-1 (BMI1) Clinical trial Target Target Info [8]
Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Target Info [8]
High mobility group protein HMGI-C (HMGA2) Literature-reported Target Target Info [11]
Protein(s) Regulated by This miRNA GRB2-associated-binding protein 2 Regulated Protein [4]
Insulin-like growth factor 2 mRNA-binding protein 1 Regulated Protein [13]
Mothers against decapentaplegic homolog 2 Regulated Protein [1]
Protein argonaute-1 Regulated Protein [15]
TBC1 domain family member 9 Regulated Protein [16]
References
REF 1 Let-7g improves multiple endothelial functions through targeting transforming growth factor-beta and SIRT-1 signaling. J Am Coll Cardiol. 2014 Apr 29;63(16):1685-94.
REF 2 The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol. 2010 May;52(5):698-704.
REF 3 Hsa-let-7g miRNA targets caspase-3 and inhibits the apoptosis induced by ox-LDL in endothelial cells. Int J Mol Sci. 2013 Nov 18;14(11):22708-20.
REF 4 Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res. 2011 Oct 15;71(20):6463-74.
REF 5 Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation. J Allergy Clin Immunol. 2011 Nov;128(5):1077-85.e1-10.
REF 6 Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology. 2014 Jan;146(1):278-90.
REF 7 Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. J Hepatol. 2010 May;52(5):690-7.
REF 8 Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A). Int J Cancer. 2011 Jan 15;128(2):319-31.
REF 9 let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis. J Transl Med. 2014 Oct 5;12:281.
REF 10 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38.
REF 11 High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol Cancer. 2007 Jan 14;6:5.
REF 12 Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res. 2011 Oct 15;71(20):6463-74.
REF 13 Identification of let-7-regulated oncofetal genes. Cancer Res. 2008 Apr 15;68(8):2587-91.
REF 14 Let-7g improves multiple endothelial functions through targeting transforming growth factor-beta and SIRT-1 signaling. J Am Coll Cardiol. 2014 Apr 29;63(16):1685-94.
REF 15 Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.J Clin Invest. 2013 Mar;123(3):1057-67.
REF 16 Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. Int J Cancer. 2012 Apr 15;130(8):1787-97.

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