miRNA Details
| miRNA General Information | |||||
|---|---|---|---|---|---|
| miRNA Mature ID | hsa-miR-1246 | ||||
| miRNA Stemloop AC | MI0006381 | ||||
| miRNA Stemloop ID | hsa-mir-1246 | ||||
| Sequence | aauggauuuuuggagcagg | ||||
| TTD Target(s) Regulated by This miRNA | Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | Target Info | [1] | |
| Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) | Patented-recorded Target | Target Info | [2] | ||
| cAMP-dependent protein kinase A type I (PRKAR1A) | Literature-reported Target | Target Info | [3] | ||
| Protein(s) Regulated by This miRNA | Axin-2 | Regulated Protein | [1] | ||
| Nuclear factor 1 B-type | Regulated Protein | [5] | |||
| References | |||||
| REF 1 | Octamer 4/microRNA-1246 signaling axis drives Wnt/-catenin activation in liver cancer stem cells. Hepatology. 2016 Dec;64(6):2062-2076. | ||||
| REF 2 | Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells. Oncogenesis. 2014 May 26;3:e104. | ||||
| REF 3 | miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget. 2017 Jul 4;8(27):43897-43914. | ||||
| REF 4 | Octamer 4/microRNA-1246 signaling axis drives Wnt/-catenin activation in liver cancer stem cells. Hepatology. 2016 Dec;64(6):2062-2076. | ||||
| REF 5 | p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB.Oncol Rep. 2015 Mar;33(3):1335-41. | ||||
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