miRNA General Information
miRNA Mature ID hsa-miR-132-3p
miRNA Stemloop AC MI0000449
miRNA Stemloop ID hsa-mir-132
Sequence uaacagucuacagccauggucg
TTD Target(s) Regulated by This miRNA Epidermal growth factor receptor (EGFR) Successful Target Target Info [1]
Fibroblast growth factor-2 (FGF2) Successful Target Target Info [2]
Matrix metalloproteinase-9 (MMP-9) Clinical trial Target Target Info [3]
Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Target Info [4]
NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Target Info [5]
Growth/differentiation factor 5 (GDF-5) Clinical trial Target Target Info [6]
Proheparin-binding EGF-like growth factor (HBEGF) Clinical trial Target Target Info [7]
Proto-oncogene c-RAF (c-RAF) Clinical trial Target Target Info [1]
Renal carcinoma antigen NY-REN-64 (IRAK-4) Clinical trial Target Target Info [8]
Brain-derived neurotrophic factor (BDNF) Clinical trial Target Target Info [9]
G2/mitotic-specific cyclin B1 (CCNB1) Patented-recorded Target Target Info [10]
Cyclin A2 (CCNA2) Literature-reported Target Target Info [10]
Proto-oncogene c-Crk (c-Crk) Literature-reported Target Target Info [7]
Forkhead box protein O1A (FOXO1) Literature-reported Target Target Info [11]
HepG2 glucose transporter (SLC2A1) Preclinical Target Target Info [12]
GTPase activating protein (RASA1) Literature-reported Target Target Info [13]
Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Target Info [14]
Hepatocellular carcinoma-associated protein (HCAP) Literature-reported Target Target Info [15]
Transcription factor SOX-5 (SOX5) Literature-reported Target Target Info [16]
Protein(s) Regulated by This miRNA Jupiter microtubule associated homolog 1 Regulated Protein [4]
Kelch-like protein 11 Regulated Protein [4]
Mothers against decapentaplegic homolog 2 Regulated Protein [18]
Mucin-13 Regulated Protein [19]
Phosphatidylinositol 3-kinase regulatory subunit gamma Regulated Protein [20]
Protein argonaute-2 Regulated Protein [21]
Protein sprouty homolog 1 Regulated Protein [22]
Retinoblastoma-associated protein Regulated Protein [10]
Rho GTPase-activating protein 32 Regulated Protein [24]
Sprouty-related, EVH1 domain-containing protein 1 Regulated Protein [22]
Talin-2 Regulated Protein [25]
Tight junction-associated protein 1 Regulated Protein [26]
Transcription factor SOX-4 Regulated Protein [27]
Transcription factor SOX-6 Regulated Protein [6]
References
REF 1 MicroRNA-7 as a tumor suppressor and novel therapeutic for adrenocortical carcinoma. Oncotarget. 2015 Nov 3;6(34):36675-88.
REF 2 An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med. 2013 Jan;19(1):74-82.
REF 3 miR-132 Regulates Dendritic Spine Structure by Direct Targeting of Matrix Metalloproteinase 9 mRNA. Mol Neurobiol. 2016 Sep;53(7):4701-12.
REF 4 Rapid regulation of microRNA following induction of long-term potentiation in vivo. Front Mol Neurosci. 2014 Dec 9;7:98.
REF 5 MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol. 2009 Nov;23(11):1876-84.
REF 6 MiR-132-3p Regulates the Osteogenic Differentiation of Thoracic Ligamentum Flavum Cells by Inhibiting Multiple Osteogenesis-Related Genes. Int J Mol Sci. 2016 Aug 20;17(8). pii: E1370.
REF 7 MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007 Jul 6;27(1):91-105.
REF 8 Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol. 2013 Feb 1;190(3):1250-63.
REF 9 Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One. 2013 May 21;8(5):e63648.
REF 10 miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011 Mar 25;406(4):518-23.
REF 11 miR-132 upregulation promotes gastric cancer cell growth through suppression of FoxO1 translation. Tumour Biol. 2015 Aug 23. [Epub ahead of print]
REF 12 miR-132 mediates a metabolic shift in prostate cancer cells by targeting Glut1. FEBS Open Bio. 2016 Jun 8;6(7):735-41.
REF 13 Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res. 2011 Sep 30;109(8):894-906.
REF 14 Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene. 2010 Apr 15;29(15):2302-8.
REF 15 Hsa-miR-132 inhibits proliferation of hepatic carcinoma cells by targeting YAP. Cell Biochem Funct. 2015 Jul;33(5):326-33.
REF 16 Krpel-like factor 9 inhibits glioma cell proliferation and tumorigenicity via downregulation of miR-21. Cancer Lett. 2015 Jan 28;356(2 Pt B):547-55.
REF 17 Rapid regulation of microRNA following induction of long-term potentiation in vivo. Front Mol Neurosci. 2014 Dec 9;7:98.
REF 18 miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells.IUBMB Life. 2015 May;67(5):380-94.
REF 19 Reduction of miR 32 p contributes to gastric cancer proliferation by targeting MUC13.Mol Med Rep. 2017 May;15(5):3055-3061.
REF 20 MiR-132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3.Int J Oncol. 2015 Oct;47(4):1585-93.
REF 21 Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells.Int J Biochem Cell Biol. 2015 Dec;69:75-84.
REF 22 MicroRNA-132/212 family enhances arteriogenesis after hindlimbschaemia through modulation of the Ras-MAPK pathway.J Cell Mol Med. 2015 Aug;19(8):1994-2005.
REF 23 miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011 Mar 25;406(4):518-23.
REF 24 A microRNA-based gene dysregulation pathway in Huntington's disease. Neurobiol Dis. 2008 Mar;29(3):438-45.
REF 25 DNA methylation silences miR-132 in prostate cancer. Oncogene. 2013 Jan 3;32(1):127-34.
REF 26 Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20473-8.
REF 27 Aryl hydrocarbon receptor-microRNA-212/132 axis in human breast cancer suppresses metastasis by targeting SOX4.Mol Cancer. 2015 Sep 17;14:172.
REF 28 MiR-132-3p Regulates the Osteogenic Differentiation of Thoracic Ligamentum Flavum Cells by Inhibiting Multiple Osteogenesis-Related Genes. Int J Mol Sci. 2016 Aug 20;17(8). pii: E1370.

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