miRNA General Information
miRNA Mature ID hsa-miR-142-3p
miRNA Stemloop AC MI0000458
miRNA Stemloop ID hsa-mir-142
Sequence uguaguguuuccuacuuuaugga
TTD Target(s) Regulated by This miRNA ATP-binding cassette transporter G2 (ABCG2) Successful Target Target Info [1]
Interleukin-6 (IL6) Successful Target Target Info [2]
Protein kinase C alpha (PRKCA) Successful Target Target Info [3]
TGF-beta receptor type I (TGFBR1) Clinical trial Target Target Info [4]
Rho-associated protein kinase 2 (ROCK2) Successful Target Target Info [5]
Interleukin-1 alpha (IL1A) Clinical trial Target Target Info [6]
Monoglyceride lipase (MAGL) Clinical trial Target Target Info [7]
Prominin-1 (PROM1) Clinical trial Target Target Info [8]
M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Target Info [9]
Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Target Info [10]
Ras-related C3 botulinum toxin substrate 1 (RAC1) Literature-reported Target Target Info [11]
Leucine-rich repeat-containing GPCR 5 (LGR5) Clinical trial Target Target Info [1]
High mobility group protein B1 (HMGB1) Literature-reported Target Target Info [12]
High mobility group protein HMG-I/Y (HMGA1) Literature-reported Target Target Info [7]
Homeobox protein Hox-A7 (HOXA7) Literature-reported Target Target Info [13]
Protein(s) Regulated by This miRNA Adenomatous polyposis coli protein Regulated Protein [14]
Aryl hydrocarbon receptor nuclear translocator-like protein 1 Regulated Protein [15]
Biorientation of chromosomes in cell division protein 1 Regulated Protein [16]
Coiled-coil domain-containing protein 6 Regulated Protein [10]
Cyclin-T2 Regulated Protein [18]
Dedicator of cytokinesis protein 6 Regulated Protein [19]
DNA repair protein XRCC1 Regulated Protein [20]
E3 SUMO-protein ligase EGR2 Regulated Protein [21]
E3 ubiquitin-protein ligase HECTD1 Regulated Protein [10]
Heat shock 70 kDa protein 1B Regulated Protein [22]
Homeobox protein Hox-A10 Regulated Protein [13]
Homeobox protein Hox-A9 Regulated Protein [13]
Lipoma-preferred partner Regulated Protein [24]
Neural Wiskott-Aldrich syndrome protein Regulated Protein [10]
Protein mono-ADP-ribosyltransferase TIPARP Regulated Protein [10]
Ras-related protein Rab-2A Regulated Protein [10]
SUN domain-containing ossification factor Regulated Protein [10]
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Regulated Protein [18]
Thrombospondin-4 Regulated Protein [25]
Transforming growth factor beta activator LRRC32 Regulated Protein [26]
Twinfilin-1 Regulated Protein [10]
Tyrosine-protein phosphatase non-receptor type 23 Regulated Protein [27]
Uncharacterized protein C18orf25 Regulated Protein [10]
USP6 N-terminal-like protein Regulated Protein [10]
References
REF 1 MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells. J Mol Med (Berl). 2013 Aug;91(8):989-1000.
REF 2 Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. Blood. 2011 Jun 9;117(23):6172-83.
REF 3 MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts. Sci Rep. 2016 Apr 26;6:24980.
REF 4 MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007 Jul 6;27(1):91-105.
REF 5 Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. Nucleic Acids Res. 2016 Sep 6;44(15):7120-31.
REF 6 MicroRNA profiling of Epstein-Barr virus-associated NK/T-cell lymphomas by deep sequencing. PLoS One. 2012;7(8):e42193.
REF 7 EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21.
REF 8 Combined characterization of microRNA and mRNA profiles delineates early differentiation pathways of CD133+ and CD34+ hematopoietic stem and progenitor cells. Stem Cells. 2011 May;29(5):847-57.
REF 9 miR-142-3p inhibits cancer cell proliferation by targeting CDC25C. Cell Prolif. 2016 Feb;49(1):58-68.
REF 10 MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676.
REF 11 MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells. FEBS Lett. 2011 May 6;585(9):1322-30.
REF 12 MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10800-7.
REF 13 MicroRNA-142-3p inhibits cell proliferation in human acute lymphoblastic leukemia by targeting the MLL-AF4 oncogene. Mol Biol Rep. 2013 Dec;40(12):6811-9.
REF 14 miR-42p promotes osteoblast differentiation by modulating Wnt signaling.Mol Med Rep. 2013 Feb;7(2):689-93.
REF 15 Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice.PLoS One. 2011;6(7):e22586.
REF 16 Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells.Oncotarget. 2016 Sep 13;7(37):60432-60445.
REF 17 MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676.
REF 18 MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood. 2012 May 24;119(21):4992-5004.
REF 19 miR-142-3p Is a Regulator of the TGF-Mediated Vascular Smooth Muscle Cell Phenotype.J Cell Biochem. 2015 Oct;116(10):2325-33.
REF 20 Oncogenic microRNA-142-3p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma. Oncol Lett. 2016 Feb;11(2):1235-1241.
REF 21 A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages.Biochim Biophys Acta. 2013 Aug;1833(8):1936-46.
REF 22 Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.Mol Cancer Ther. 2013 Jul;12(7):1266-75.
REF 23 MicroRNA-142-3p inhibits cell proliferation in human acute lymphoblastic leukemia by targeting the MLL-AF4 oncogene. Mol Biol Rep. 2013 Dec;40(12):6811-9.
REF 24 miR-142-3p enhances FcRI-mediated degranulation in mast cells.Biochem Biophys Res Commun. 2014 Jan 17;443(3):980-6.
REF 25 Over-expression of Thrombospondin 4 correlates with loss of miR-142 and contributes to migration and vascular invasion of advanced hepatocellular carcinoma.Oncotarget. 2017 Apr 4;8(14):23277-23288.
REF 26 miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant.J Immunol. 2013 Jun 15;190(12):6579-88.
REF 27 Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.J Biol Chem. 2013 Aug 16;288(33):23990-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.