miRNA General Information
miRNA Mature ID hsa-miR-181b-5p
miRNA Stemloop AC MI0000270 | MI0000683
miRNA Stemloop ID hsa-mir-181b-1 | hsa-mir-181b-2
Sequence aacauucauugcugucggugggu
TTD Target(s) Regulated by This miRNA Estrogen receptor (ESR) Successful Target Target Info [1]
Glutamate receptor AMPA 2 (GRIA2) Successful Target Target Info [2]
T-cell leukemia/lymphoma protein 1A (TCL1A) Literature-reported Target Target Info [3]
Protein(s) Regulated by This miRNA Adenylate cyclase type 9 Regulated Protein [4]
Bcl-2-like protein 11 Regulated Protein [5]
Caspase recruitment domain-containing protein 10 Regulated Protein [6]
E3 ubiquitin-protein ligase RING2 Regulated Protein [7]
Elastin Regulated Protein [8]
Hexokinase-2 Regulated Protein [9]
Homeobox protein CDX-2 Regulated Protein [10]
Homeobox protein SIX2 Regulated Protein [11]
Importin subunit alpha-3 Regulated Protein [12]
Metalloproteinase inhibitor 3 Regulated Protein [13]
Nuclear factor 1 A-type Regulated Protein [14]
Pre-B-cell leukemia transcription factor 3 Regulated Protein [15]
Programmed cell death protein 10 Regulated Protein [16]
Programmed cell death protein 4 Regulated Protein [17]
Ras association domain-containing protein 1 Regulated Protein [18]
Ras-related protein Rap-1b Regulated Protein [19]
Serine/threonine-protein kinase NLK Regulated Protein [10]
Transcription factor GATA-6 Regulated Protein [10]
Transcription factor GATA-6 Regulated Protein [16]
Transmembrane emp24 domain-containing protein 7 Regulated Protein [20]
Ubiquitin carboxyl-terminal hydrolase CYLD Regulated Protein [21]
Ubiquitin carboxyl-terminal hydrolase CYLD Regulated Protein [22]
Visinin-like protein 1 Regulated Protein [2]
Zinc finger protein PLAG1 Regulated Protein [24]
REF 1 The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol. 2007 May;21(5):1132-47.
REF 2 Dysregulation of miRNA 181b in the temporal cortex in schizophrenia. Hum Mol Genet. 2008 Apr 15;17(8):1156-68.
REF 3 Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res. 2006 Dec 15;66(24):11590-3.
REF 4 miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells.FEBS Lett. 2014 Jan 3;588(1):124-30.
REF 5 MiR-181b promotes chemoresistance in breast cancer by regulating Bim expression.Oncol Rep. 2016 Feb;35(2):683-90.
REF 6 MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10.FASEB J. 2016 Sep;30(9):3216-26.
REF 7 Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell. 2011 Aug 16;20(2):187-99.
REF 8 MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin.Circ Res. 2017 Jan 6;120(1):49-65.
REF 9 Involvement of EZH2 in aerobic glycolysis of prostate cancer through miR-181b/HK2 axis.Oncol Rep. 2017 Mar;37(3):1430-1436.
REF 10 Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells.Hepatology. 2009 Aug;50(2):472-80.
REF 11 MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro.Biochem Biophys Res Commun. 2013 Nov 1;440(4):495-501.
REF 12 Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma.Sci Rep. 2015 Aug 18;5:13072.
REF 13 TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.Oncogene. 2010 Mar 25;29(12):1787-97.
REF 14 MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis.Infect Immun. 2014 Sep;82(9):3816-25.
REF 15 Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.Blood. 2012 Mar 8;119(10):2314-24.
REF 16 MicroRNA Stability in Postmortem FFPE Tissues: Quantitative Analysis Using Autoptic Samples from Acute Myocardial Infarction Patients.PLoS One. 2015 Jun 5;10(6):e0129338.
REF 17 miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4. Protein Cell. 2016 Oct;7(10):722-734.
REF 18 PML/RAR-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia.Cancer Res. 2015 Aug 15;75(16):3411-24.
REF 19 miR-181 subunits enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeleton remodeling in glioblastoma cells.Med Oncol. 2014 Apr;31(4):892.
REF 20 miR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients.Biochem Biophys Res Commun. 2012 Apr 27;421(1):4-8.
REF 21 STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell. 2010 Aug 27;39(4):493-506.
REF 22 Reciprocal activation between STAT3 and miR-181b regulates the proliferation of esophageal cancer stem-like cells via the CYLD pathway.Mol Cancer. 2016 May 17;15(1):40.
REF 23 Dysregulation of miRNA 181b in the temporal cortex in schizophrenia. Hum Mol Genet. 2008 Apr 15;17(8):1156-68.
REF 24 miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia.Blood. 2009 Oct 8;114(15):3255-64.

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