miRNA General Information
miRNA Mature ID hsa-miR-18b-5p
miRNA Stemloop AC MI0001518
miRNA Stemloop ID hsa-mir-18b
Sequence uaaggugcaucuagugcaguuag
TTD Target(s) Regulated by This miRNA Estrogen receptor (ESR) Successful Target Target Info [1]
Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Target Info [2]
Connective tissue growth factor (CTGF) Clinical trial Target Target Info [3]
Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Target Info [4]
Insulin-like growth factor-I (IGF1) Clinical trial Target Target Info [5]
Protein(s) Regulated by This miRNA Forkhead box protein N1 Regulated Protein [6]
Mothers against decapentaplegic homolog 2 Regulated Protein [7]
Trinucleotide repeat-containing gene 6B protein Regulated Protein [8]
REF 1 Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene. 2009 Nov 5;28(44):3926-36.
REF 2 The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression. J Natl Cancer Inst. 2013 Mar 20;105(6):433-42.
REF 3 Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. Cell Death Dis. 2013 May 16;4:e634.
REF 4 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 5 microRNA-18b modulates insulin-like growth factor-1 expression in deer antler cell proliferation by directly targeting its 3' untranslated region. DNA Cell Biol. 2015 Apr;34(4):282-9.
REF 6 miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells.Stem Cells Dev. 2014 May 15;23(10):1149-56.
REF 7 miR-18b inhibits TGF-1-induced differentiation of hair follicle stem cells into smooth muscle cells by targeting SMAD2.Biochem Biophys Res Commun. 2013 Aug 30;438(3):551-6.
REF 8 The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis.BMC Cancer. 2013 Mar 4;13:99.

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