miRNA General Information
miRNA Mature ID hsa-miR-199b-5p
miRNA Stemloop AC MI0000282
miRNA Stemloop ID hsa-mir-199b
Sequence cccaguguuuagacuaucuguuc
TTD Target(s) Regulated by This miRNA Erbb2 tyrosine kinase receptor (HER2) Successful Target Target Info [1]
Tyrosine-protein kinase Kit (KIT) Successful Target Target Info [2]
NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Target Info [3]
Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Target Info [4]
Epithelial discoidin domain receptor 1 (DDR1) Patented-recorded Target Target Info [5]
Lysine N-methyltransferase 3A (SETD2) Literature-reported Target Target Info [6]
Laminin gamma-2 subunit (LAMC2) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Cyclin-L1 Regulated Protein [2]
Growth factor receptor-bound protein 10 Regulated Protein [2]
Integrin alpha-3 Regulated Protein [9]
Podocalyxin Regulated Protein [5]
Protein jagged-1 Regulated Protein [11]
Protein SET Regulated Protein [12]
Serine/threonine-protein kinase NLK Regulated Protein [2]
Transcription factor HES-1 Regulated Protein [13]
Transcription initiation factor TFIID subunit 9B Regulated Protein [2]
References
REF 1 MiR-199b-5p targets HER2 in breast cancer cells. J Cell Biochem. 2013 Jul;114(7):1457-63.
REF 2 The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2. Mol Cells. 2014 Mar;37(3):213-9.
REF 3 Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling. Oncotarget. 2016 Jun 7;7(23):35092-105.
REF 4 Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1 in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. J Gastroenterol Hepatol. 2011 Nov;26(11):1630-7.
REF 5 miR-199b-5p directly targets PODXL and DDR1 and decreased levels of miR-199b-5p correlate with elevated expressions of PODXL and DDR1 in acute myeloid leukemia. Am J Hematol. 2012 Apr;87(4):442-6.
REF 6 MiR199b suppresses expression of hypoxia-inducible factor 1 (HIF-1) in prostate cancer cells. Int J Mol Sci. 2013 Apr 17;14(4):8422-36.
REF 7 A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 2004 May 15;18(10):1165-78.
REF 8 The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2. Mol Cells. 2014 Mar;37(3):213-9.
REF 9 Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer.Br J Cancer. 2017 Apr 11;116(8):1077-1087.
REF 10 miR-199b-5p directly targets PODXL and DDR1 and decreased levels of miR-199b-5p correlate with elevated expressions of PODXL and DDR1 in acute myeloid leukemia. Am J Hematol. 2012 Apr;87(4):442-6.
REF 11 Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer.Oncotarget. 2014 Feb 28;5(4):944-58.
REF 12 Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma.Cancer Lett. 2010 May 1;291(1):99-107.
REF 13 MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma.PLoS One. 2009;4(3):e4998.

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