miRNA General Information
miRNA Mature ID hsa-miR-19b-3p
miRNA Stemloop AC MI0000074 | MI0000075
miRNA Stemloop ID hsa-mir-19b-1 | hsa-mir-19b-2
Sequence ugugcaaauccaugcaaaacuga
TTD Target(s) Regulated by This miRNA Estrogen receptor (ESR) Successful Target Target Info [1]
Protein(s) Regulated by This miRNA 5'-AMP-activated protein kinase catalytic subunit alpha-1 Regulated Protein [2]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 Regulated Protein [3]
AT-rich interactive domain-containing protein 4B Regulated Protein [4]
Ataxin-1 Regulated Protein [5]
ATP-binding cassette sub-family A member 2 Regulated Protein [3]
B-cell lymphoma 3 protein Regulated Protein [6]
Bcl-2-like protein 11 Regulated Protein [7]
Butyrophilin subfamily 2 member A2 Regulated Protein [3]
Calsequestrin-1 Regulated Protein [3]
Chorion-specific transcription factor GCMa Regulated Protein [8]
Cullin-5 Regulated Protein [9]
E3 ubiquitin-protein ligase MYLIP Regulated Protein [4]
G protein-coupled receptor kinase 4 Regulated Protein [3]
GTP-binding protein REM 1 Regulated Protein [3]
Histone acetyltransferase KAT2A Regulated Protein [3]
Homeobox protein PKNOX1 Regulated Protein [10]
Homeodomain-interacting protein kinase 1 Regulated Protein [11]
Homeodomain-interacting protein kinase 3 Regulated Protein [4]
Hsc70-interacting protein Regulated Protein [3]
Max dimerization protein 1 Regulated Protein [12]
Mediator of RNA polymerase II transcription subunit 28 Regulated Protein [3]
Microtubule-associated tumor suppressor 1 Regulated Protein [13]
Mothers against decapentaplegic homolog 4 Regulated Protein [14]
Myb-related protein B Regulated Protein [3]
NEDD4 family-interacting protein 1 Regulated Protein [3]
Pituitary homeobox 1 Regulated Protein [15]
Piwi-like protein 4 Regulated Protein [3]
Pregnancy-specific beta-1-glycoprotein 4 Regulated Protein [3]
Protein FAM218A Regulated Protein [3]
Rho guanine nucleotide exchange factor 28 Regulated Protein [3]
Ribonuclease pancreatic Regulated Protein [3]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Regulated Protein [2]
Signal-regulatory protein beta-2 Regulated Protein [3]
Small G protein signaling modulator 3 Regulated Protein [3]
Tetratricopeptide repeat protein 9C Regulated Protein [3]
Transcriptional protein SWT1 Regulated Protein [3]
Transmembrane protein 107 Regulated Protein [3]
Ubiquitin carboxyl-terminal hydrolase 34 Regulated Protein [3]
WD repeat and FYVE domain-containing protein 2 Regulated Protein [3]
Zinc finger protein 772 Regulated Protein [3]
REF 1 The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol. 2007 May;21(5):1132-47.
REF 2 Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia.Nat Cell Biol. 2010 Apr;12(4):372-9.
REF 3 Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells.J Gastroenterol. 2012 Aug;47(8):883-95.
REF 4 Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia.Cancer Res. 2007 Jun 15;67(12):5699-707.
REF 5 miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.Nat Neurosci. 2008 Oct;11(10):1137-9.
REF 6 MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3.Oncol Rep. 2016 Oct;36(4):2079-86.
REF 7 MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90.
REF 8 The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation. Mol Cell Biol. 2013 May;33(9):1782-96.
REF 9 MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5.Cancer Lett. 2012 Sep 28;322(2):148-58.
REF 10 The miR-17 2 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.Leuk Res. 2016 Jul;46:51-60.
REF 11 MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells. J Cell Sci. 2013 Sep 15;126(Pt 18):4220-9.
REF 12 MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1.Cell Death Dis. 2014 Mar 27;5:e1144.
REF 13 Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer.Protein Cell. 2017 Jun;8(6):455-466.
REF 14 High iodine blocks a Notch/miR-19 loop activated by the BRAF(V600E) oncoprotein and restores the response to TGF in thyroid follicular cells.Thyroid. 2014 Mar;24(3):453-62.
REF 15 miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells.Sci Rep. 2015 Feb 3;5:8201.

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