miRNA General Information
miRNA Mature ID hsa-miR-338-3p
miRNA Stemloop AC MI0000814
miRNA Stemloop ID hsa-mir-338
Sequence uccagcaucagugauuuuguug
TTD Target(s) Regulated by This miRNA Matrix metalloproteinase-2 (MMP-2) Successful Target Target Info [1]
Smoothened homolog (SMO) Successful Target Target Info [2]
Neuropilin-1 (NRP1) Successful Target Target Info [3]
Matrix metalloproteinase-9 (MMP-9) Clinical trial Target Target Info [1]
TNF alpha converting enzyme (ADAM17) Clinical trial Target Target Info [4]
G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Target Info [5]
Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Target Info [6]
Neural cadherin (CDH2) Clinical trial Target Target Info [7]
Pyruvate kinase M2 (PKM) Clinical trial Target Target Info [8]
Integrin beta-3 (ITGB3) Literature-reported Target Target Info [9]
Zinc finger E-box-binding homeobox 2 (ZEB2) Literature-reported Target Target Info [10]
SSX2-interacting protein (SSX2IP) Literature-reported Target Target Info [11]
Protein(s) Regulated by This miRNA Cytosolic phospholipase A2 beta Regulated Protein [12]
Disabled homolog 2-interacting protein Regulated Protein [13]
Insulin receptor substrate 2 Regulated Protein [14]
Metastasis-associated in colon cancer protein 1 Regulated Protein [10]
Microtubule-associated protein 1A Regulated Protein [13]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Regulated Protein [16]
Pyruvate kinase PKLR Regulated Protein [17]
RNA-binding protein Nova-1 Regulated Protein [13]
Tafazzin Regulated Protein [18]
Transcription factor SOX-4 Regulated Protein [19]
Ubiquitin-conjugating enzyme E2 Q1 Regulated Protein [13]
Zinc finger and BTB domain-containing protein 18 Regulated Protein [13]
REF 1 miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. J Pathol. 2011 Nov;225(3):463-72.
REF 2 miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened. World J Gastroenterol. 2013;19(14):2197-207.
REF 3 MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression. PLoS One. 2014 Apr 15;9(4):e94422.
REF 4 MiR-338-3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10922-8.
REF 5 The effect of miR-338-3p on HBx deletion-mutant (HBx-d382) mediated liver-cell proliferation through CyclinD1 regulation. PLoS One. 2012;7(8):e43204.
REF 6 MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1 in nasopharyngeal carcinoma. Oncol Rep. 2015 Oct;34(4):1943-52.
REF 7 J Biol Chem. 2016 Aug 19;291(34):17897-906.
REF 8 MiR-338-3p targets pyruvate kinase M2 and affects cell proliferation and metabolism of ovarian cancer. Am J Transl Res. 2016 Jul 15;8(7):3266-73.
REF 9 miR-338 inhibits the metastasis of lung cancer by targeting integrin 3. Oncol Rep. 2016 Sep;36(3):1467-74.
REF 10 MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling. Oncotarget. 2015 Jun 20;6(17):15222-34.
REF 11 Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. PLoS One. 2013 Jun 24;8(6):e66782.
REF 12 Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition.J Pathol. 2009 Jan;217(1):113-21.
REF 13 An intronic microRNA silences genes that are functionally antagonistic to its host gene.Nucleic Acids Res. 2008 Sep;36(16):5232-41.
REF 14 MiR-338-3p inhibits the growth and invasion of non-small cell lung cancer cells by targeting IRS2. Am J Cancer Res. 2017 Jan 1;7(1):53-63.
REF 15 MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling. Oncotarget. 2015 Jun 20;6(17):15222-34.
REF 16 miR-338-3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a.FEBS Lett. 2013 Nov 15;587(22):3729-37.
REF 17 Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR-338-3p-PKLR axis in hepatocellular carcinoma.Hepatology. 2015 Oct;62(4):1145-59.
REF 18 HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma.Oncotarget. 2015 Oct 6;6(30):29048-59.
REF 19 MicroRNA-338-3p functions as tumor suppressor in breast cancer by targeting SOX4.Int J Oncol. 2015 Oct;47(4):1594-602.

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