miRNA General Information
miRNA Mature ID hsa-miR-491-5p
miRNA Stemloop AC MI0003126
miRNA Stemloop ID hsa-mir-491
Sequence aguggggaacccuuccaugagg
TTD Target(s) Regulated by This miRNA Epidermal growth factor receptor (EGFR) Successful Target Target Info [1]
Matrix metalloproteinase-2 (MMP-2) Successful Target Target Info [2]
Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [1]
Dopamine transporter (DAT) Successful Target Target Info [3]
Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Target Info [4]
Matrix metalloproteinase-9 (MMP-9) Clinical trial Target Target Info [5]
Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target Target Info [6]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [7]
Notch-3 receptor (NOTCH3) Clinical trial Target Target Info [8]
Protein(s) Regulated by This miRNA ARF GTPase-activating protein GIT1 Regulated Protein [9]
Calpain small subunit 1 Regulated Protein [10]
Chromodomain-helicase-DNA-binding protein 4 Regulated Protein [11]
Insulin-like growth factor 2 mRNA-binding protein 1 Regulated Protein [12]
Lysine-specific demethylase 4B Regulated Protein [13]
Protein Wnt-3a Regulated Protein [14]
Transcription initiation factor TFIID subunit 10 Regulated Protein [11]
REF 1 Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. Oncogene. 2015 Mar 26;34(13):1619-1628.
REF 2 MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition. Liver Int. 2013 Sep;33(8):1271-80.
REF 3 miR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells. Neurosci Bull. 2016 Dec;32(6):512-522.
REF 4 Inhibition of TGF-/SMAD3/NF-B signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. Toxicol Lett. 2014 Nov 18;231(1):55-61.
REF 5 Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme. Brain Res. 2011 Sep 9;1411:108-15.
REF 6 miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2008 Oct 24;375(3):315-20.
REF 7 MicroRNA miR-491-5p targeting both TP53 and Bcl-XL induces cell apoptosis in SW1990 pancreatic cancer cells through mitochondria mediated pathway. Molecules. 2012 Dec 11;17(12):14733-47.
REF 8 miR-491-5p suppresses cell growth and invasion by targeting Notch3 in nasopharyngeal carcinoma. Oncol Rep. 2016 Jun;35(6):3541-7.
REF 9 miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis.Cancer Res. 2014 Feb 1;74(3):751-64.
REF 10 MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1. Int J Biol Sci. 2016 Nov 5;12(12):1437-1447.
REF 11 MiR-205 silences MED1 in hypoxic primary human trophoblasts. FASEB J. 2010 Jun;24(6):2030-9.
REF 12 MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer. Am J Transl Res. 2016 Feb 15;8(2):485-95.
REF 13 miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ER-positive breast cancer.FEBS Lett. 2015 Mar 24;589(7):812-21.
REF 14 miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/-catenin signaling in the development of gastric cancer.Cell Death Dis. 2017 Mar 30;8(3):e2714.

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