miRNA General Information
miRNA Mature ID hsa-miR-504-5p
miRNA Stemloop AC MI0003189
miRNA Stemloop ID hsa-mir-504
Sequence agacccuggucugcacucuauc
TTD Target(s) Regulated by This miRNA Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [1]
Dopamine D1 receptor (D1R) Successful Target Target Info [2]
Vascular endothelial growth factor A (VEGFA) Successful Target Target Info [3]
Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Target Info [4]
Cellular tumor antigen p53 (TP53) Clinical trial Target Target Info [4]
Apoptosis mediating surface antigen FAS (FAS) Clinical trial Target Target Info [4]
Trefoil factor-1 (TFF1) Clinical trial Target Target Info [5]
Bcl-2-binding component 3 (BBC3) Literature-reported Target Target Info [4]
Protein(s) Regulated by This miRNA Apoptosis regulator BAX Regulated Protein [4]
Growth arrest and DNA damage-inducible protein GADD45 alpha Regulated Protein [4]
Quinone oxidoreductase PIG3 Regulated Protein [4]
Transcription elongation factor A protein-like 1 Regulated Protein [4]
References
REF 1 microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma. Int J Oncol. 2014 Jun;44(6):2085-92.
REF 2 Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504. Biol Psychiatry. 2009 Apr 15;65(8):702-5.
REF 3 The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008 Mar 5;3(3):e1719.
REF 4 Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell. 2010 Jun 11;38(5):689-99.
REF 5 TFF1 activates p53 through down-regulation of miR-504 in gastric cancer. Oncotarget. 2014 Jul 30;5(14):5663-73.
REF 6 Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell. 2010 Jun 11;38(5):689-99.

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