Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T14463 | Target Info | |||
Target Name | Sterol O-acyltransferase (SOAT) | ||||
Synonyms |
Cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; ACAT; ACACT
Click to Show/Hide
|
||||
Target Type | Clinical trial Target | ||||
Gene Name | SOAT1; SOAT2 | ||||
UniProt ID |
Poor Binders of This Target (in total, 50 binders) | Download | Top | |||
---|---|---|---|---|---|
Compound Name |
PMID25470667-Compound-K-604
Click to Show/Hide
|
Patented | Compound Info | ||
Activity | Sterol O-acyltransferase 2 |
IC50 = 102850 nM
|
[1] | ||
Compound Name |
TERRITREM B
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Territrem B; Territreme B; CHEMBL24686; 70407-20-4; 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3,4,5-trimethoxyphenyl)-, (4aR,6aR,12aS,12bS)-; 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3,4,5-trimethoxyphenyl)-, (4aR-(4a-alpha,6a-beta,12a-alpha,12b-beta))-; TERRITREMB(RG); 4m0f; AC1L3FVE
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 50000 nM
|
[2] | ||
Compound Name |
Cudraxanthone M
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
cudraxanthone M; CHEMBL371024; BDBM50175018
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 56800 nM
|
[3] | ||
Compound Name |
Cudraxanthone D
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
cudraxanthone D; 96552-41-9; CHEMBL425926; MolPort-035-706-470; ZINC13411981; BDBM50175019; AKOS032948528; 4CN-1670; W2633; 2,3,8-trihydroxy-6-methoxy-5-(2-methyl-3-buten-2-yl)-1-(3-methyl- 2-buten-1-yl)-9h-xanthen-9-one
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 57600 nM
|
[3] | ||
Sterol O-acyltransferase 2 |
IC50 = 75200 nM
|
[3] | |||
Compound Name |
Octanoic acid biphenyl-2-ylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL408322; octanoic acid biphenyl-2-ylamide; SCHEMBL15472053
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 60900 nM
|
[4] | ||
Compound Name |
Elaidoylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Oleamide; Oleic acid amide; 301-02-0; Oleylamide; Oleyl amide; Adogen 73; Crodamide O; Slip-eze; Armoslip CP; Crodamide OR; cis-9,10-Octadecenoamide; (Z)-9-OCTADECENAMIDE; (9Z)-octadec-9-enamide; 9-Octadecenamide, (Z)-; (Z)-octadec-9-enamide; ELAIDOYLAMIDE; 9Z-octadecenamide; 9,10-octadecenamide; Unislip 1759; Kemamide O; Petrac Slip-Eze; UNII-7L25QK8BWO; Armid O; Amide O; trans-9,10-octadecenoamide; cis-9-Octadecenamide; 9-Octadecenamide, (9Z)-; 14C-labeled oleamide; Diamide O 200; HSDB 5560; (9E)-OCTADEC-9-ENAMIDE; oleamide
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 63000 nM
|
[5] | ||
Compound Name |
Nonanoic acid biphenyl-2-ylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL270041; nonanoic acid biphenyl-2-ylamide; SCHEMBL15472054
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 64600 nM
|
[4] | ||
Compound Name |
Cudraxanthone L
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
cudraxanthone L; 135541-40-1; CHEMBL197916; MolPort-035-706-469; BDBM50175013; ZINC13412042; AKOS032948133; W2632; 1,3,6,7-tetrahydroxy-5-(3-methylbut-2-enyl)-2-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 68000 nM
|
[3] | ||
Sterol O-acyltransferase 2 |
IC50 = 74400 nM
|
[3] | |||
Compound Name |
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-Dimethoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-1-heptyloxy-2-methoxy-ethyl)-benzo[1,3]dioxole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL367216; BDBM50158056
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 50000 nM
|
[6] | ||
Compound Name |
Arisugacin A
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL283509; arisugacin; (+)-Arisugacin A; BDBM50089619; (3,4-dimethoxyphenyl)-dihydroxy-tetramethyl-[?]dione; Q15410265
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 50000 nM
|
[2] | ||
Compound Name |
[(1S,2S,5S,6R,7R,9S,10S,18R)-5,9-Diacetyloxy-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-6-yl]methyl propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2375696; BDBM50433219
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 52000 nM
|
[7] | ||
Compound Name |
Linoleamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Linoleic acid amide; (9Z,12Z)-octadeca-9,12-dienamide; 9,12-Octadecadienamide; (9Z,12Z)-Octadeca-9,12-dien-1-amide; linoleoyl amide; 9Z,12Z-octadecadienamide; UNII-5340S2UXSP; CHEMBL64122; 5340S2UXSP; linoleate amide; 9,12-Octadecadienamide, (9Z,12Z)-; BSPBio_001372; SCHEMBL124306; BML2-C09; DTXSID4042098; SCHEMBL19535589; Linoleamide, >=98% (HPLC); HMS1361E14; HMS1791E14; HMS1989E14; HMS3402E14; Octadeca-9,12-dienoic acid amide; ZINC8689950; EINECS 223-644-6; BDBM50150483; LMFA08010008; MFCD00798239; IDI1_033842; NCGC00161183-03; NCGC00161183-04; NCGC00161183-05; NCGC00161183-06; AS-62109; (9Z,12Z)-Octadeca-9,12-dienoic acid amide; BRD-K64044582-001-02-8; Q27156521; UNII-3YXD33R71G component SFIHQZFZMWZOJV-HZJYTTRNSA-N
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 53000 nM
|
[5] | ||
Compound Name |
1-[(2,5-Diphenylpyrazol-3-yl)amino]nonan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3912464; SCHEMBL15472055; BDBM182853; US9149492, 13a
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 53000 nM
|
[1] | ||
Compound Name |
N~1~-(1,3-Diphenyl-1H-pyrazol-5-yl)octanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3960481; SCHEMBL16171341; AKOS021777067; ZINC102993495; MCULE-5475448594; N~1~-(1,3-diphenyl-1H-pyrazol-5-yl)octanamide
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 53000 nM
|
[8] | ||
Compound Name |
2-Heptylsulfonyl-5,8-dimethoxynaphthalene-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335523; BDBM50430497
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 53500 nM
|
[9] | ||
Compound Name |
(S)-5,7-Dihydroxy-2-(7-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-8-(3-hydroxy-3-methylbutyl)chroman-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL218550; BDBM50193720; (S)-5,7,7''-trihydroxy-8-(3-hydroxy-3-methylbutyl)-2'',2''-dimethyl-2,6''-bichroman-4-one
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 59200 nM
|
[3] | ||
Compound Name |
3,4-Dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL360400; CAY10485; CTK8E9969; DTXSID10653142; HMS3649L12; 1377AH; BDBM50151701; ZINC27645103; SR-01000946735; SR-01000946735-1; Dibenzyl N-[3-(3,4-dihydroxyphenyl)propanoyl]-L-aspartate; 3,4-Dihydroxyhydrocinnamic acid (L-aspartic acid dibenzyl ester) amide; Dibenzyl (2S)-2-[3-(3,4-dihydroxyphenyl)propanoylamino]butanedioate; (S)-2-[3-(3,4-Dihydroxy-phenyl)-propionylamino]-succinic acid dibenzyl ester
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 60000 nM
|
[10] | ||
Sterol O-acyltransferase 2 |
IC50 = 95000 nM
|
[10] | |||
Compound Name |
2-Hexylsulfonyl-5,8-dimethoxynaphthalene-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335522; BDBM50430498
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 62500 nM
|
[9] | ||
Compound Name |
[(1S,2S,5S,6R,7R,9S,10S,18R)-5-Benzoyloxy-6-(benzoyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-9-yl] 4-cyanobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2375704; BDBM50433201
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 63000 nM
|
[7] | ||
Compound Name |
[(1S,2S,5S,6R,7R,9S,10S,18R)-5-Hexanoyloxy-6-(hexanoyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-9-yl] 4-cyanobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2375703; BDBM50433202
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 63900 nM
|
[7] | ||
Compound Name |
4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carbonyl)-cis-cyclohexanecarboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1766811; CHEMBL1766812; SCHEMBL594863; SCHEMBL1101806; SCHEMBL1102060; BDBM50341782; BDBM50341783
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 68400 nM
|
[11] | ||
Sterol O-acyltransferase 2 |
IC50 = 68400 nM
|
[11] | |||
Compound Name |
[(1S,2S,3R,11S,12S,14R,15R,18R,20S)-3-Hydroxy-1,11,15-trimethyl-18-naphthalen-1-yl-5-oxo-7-pyridin-3-yl-6,10,17,19-tetraoxapentacyclo[12.8.0.02,11.04,9.015,20]docosa-4(9),7-dien-12-yl] 4-cyanobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2398814; BDBM50436345
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 69100 nM
|
[12] | ||
Compound Name |
[(1S,2S,3R,11S,12S,14R,15R,18R,20S)-3-Hydroxy-18-(2-methoxyphenyl)-1,11,15-trimethyl-5-oxo-7-pyridin-3-yl-6,10,17,19-tetraoxapentacyclo[12.8.0.02,11.04,9.015,20]docosa-4(9),7-dien-12-yl] 4-cyanobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2398810; BDBM50436349
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 71000 nM
|
[12] | ||
Compound Name |
[(1S,2S,3R,11S,12S,14R,15R,18R,20S)-18-(2,6-Dimethylphenyl)-3-hydroxy-1,11,15-trimethyl-5-oxo-7-pyridin-3-yl-6,10,17,19-tetraoxapentacyclo[12.8.0.02,11.04,9.015,20]docosa-4(9),7-dien-12-yl] 4-cyanobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2398813; BDBM50436346
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 71200 nM
|
[12] | ||
Compound Name |
[(1S,2S,3R,11S,12S,14R,15R,18R,20S)-3-Hydroxy-1,11,15-trimethyl-18-(2-methylphenyl)-5-oxo-7-pyridin-3-yl-6,10,17,19-tetraoxapentacyclo[12.8.0.02,11.04,9.015,20]docosa-4(9),7-dien-12-yl] 4-cyanobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2398804; BDBM50436328
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 72800 nM
|
[12] | ||
Compound Name |
N-(2,5-Diphenylpyrazol-3-yl)nonanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3978838; SCHEMBL16171342
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 75000 nM
|
[8] | ||
Compound Name |
1-[(2,5-Diphenylpyrazol-3-yl)amino]decan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3941615; SCHEMBL15472056; BDBM182854; US9149492, 14a
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 75000 nM
|
[1] | ||
Compound Name |
6-{4-[trans-4-(2-Hydroxyethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2178933; SCHEMBL2254564; SCHEMBL2254569; SCHEMBL2259505; BDBM50399695
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 75000 nM
|
[13] | ||
Compound Name |
Cycloartocarpesin
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL221908; BDBM50193721; LMPK12110915; 2-(2,4-dihydroxy-phenyl)-5-hydroxy-8,8-dimethyl-8H-pyrano[3,2-g]chromen-4-one; 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethylpyrano[3,2-g]chromen-4(8H)-one; 8-(2,4-Dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one; 8-(2,4-Dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one, 9CI
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 77600 nM
|
[3] | ||
Compound Name |
4-[4-(6-Carbamoyl-3-methylpyrazin-2-yl)phenyl]cyclohexane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2178950; SCHEMBL2254152; SCHEMBL16500200; BDBM50399713; trans-4-{4-[6-(Aminocarbonyl)-3-methylpyrazin-2-yl]phenyl}cyclo-hexanecarboxylic Acid
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 79000 nM
|
[13] | ||
Compound Name |
1-(1,3-Benzodioxol-5-yl)-2-[4-[(2S,3R,4R,5S)-5-[4-[2-(3,4-dimethoxyphenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl]-3,4-dimethyl-tetrahydrofuran-2-yl]-2-methoxy-phenoxy]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL321124; BDBM50147177
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 82000 nM
|
[6] | ||
Compound Name |
Manassantin B
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Manassantin B , HPLC Grade; CHEMBL461308; SCHEMBL16442136; DTXSID60904893; BDBM50478400; J3.598.413E; Q27135283
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 82000 nM
|
[8] | ||
Compound Name |
Cudraflavanone A
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL220746; BDBM50193719; (S)-5,7,7''-trihydroxy-2'',2''-dimethyl-6-(3-methylbut-2-enyl)-2,6''-bichroman-4-one; (S)-5,7-dihydroxy-2-(7-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-6-(3-methylbut-2-enyl)chroman-4-one
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 82400 nM
|
[3] | ||
Compound Name |
4-(2,4-Dimethylpent-3-en-2-yl)-1,6,7-trihydroxy-3-methyl-9H-xanthen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL218383; BDBM50193722
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 89600 nM
|
[3] | ||
Compound Name |
(S)-2-(2,4-Dihydroxy-5-(3-methylbut-2-enyl)phenyl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chroman-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL218741; BDBM50193723
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 89600 nM
|
[3] | ||
Compound Name |
Macluraxanthone B
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL370126; Chloroxanthone A; BDBM50175012; NSC692942; NSC-692942; Q27135267; 2-(1,1-dimethylallyl)-1,3,6,7-tetrahydroxy-4-(3-methylbut-2-enyl)xanthen-9-one
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 96000 nM
|
[3] | ||
Sterol O-acyltransferase 2 |
IC50 = 112000 nM
|
[3] | |||
Compound Name |
N-Nonyl-2,5-diphenylpyrazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3976360; SCHEMBL16171343
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 97000 nM
|
[8] | ||
Compound Name |
N-Decyl-2,5-diphenylpyrazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3936896; SCHEMBL15472057; BDBM182855; US9149492, 16a
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 97000 nM
|
[1] | ||
Compound Name |
5,8-Dimethoxy-2-propylsulfonylnaphthalene-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335519; BDBM50430501
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | ||
Compound Name |
5,8-Dimethoxy-2-methylsulfinylnaphthalene-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335553; SCHEMBL4796239; BDBM50430517
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | ||
Compound Name |
2-Ethylsulfonyl-5,8-dimethoxynaphthalene-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335518; BDBM50430502
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | ||
Compound Name |
2-[4-[4-(6-Carbamoylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2178952; SCHEMBL2254386; SCHEMBL2254390; BDBM50399711
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 100000 nM
|
[13] | ||
Compound Name |
5,8-Dimethoxy-2-methylsulfonylnaphthalene-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335567; BDBM50430503
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | ||
Compound Name |
1-[5-[(5-Phenylpyridazine-3-yl)amino]pentyl]-1-heptyl-3-(2,4-difluorophenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL383811; BDBM50177893; N-(2,4-difluorophenyl)-N''-heptyl-N''-{5-[(5-phenyl-pyridazin-3-yl)amino]pentyl}urea
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 101000 nM
|
[14] | ||
Compound Name |
Chembl4288347
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL1704627; 2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide hydrochloride
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 102850 nM
|
[15] | ||
Compound Name |
5-((R)-2-{4-[(2S,3R,4S,5R)-5-(3,4-Dimethoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-phenoxy}-propyl)-benzo[1,3]dioxole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL431258; BDBM50147179
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 124000 nM
|
[16] | ||
Compound Name |
1-(1,3-Benzodioxol-5-yl)-2-[4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3966068
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 124000 nM
|
[8] | ||
Compound Name |
[(1S,2S,5S,6S,7R,9S,10S,18R)-5-Acetyloxy-6-[(2,4-dimethoxyphenyl)methylcarbamoyl]-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-9-yl] 4-cyanobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2375602; BDBM50433207
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 ~ 126300 nM
|
[7] | ||
Compound Name |
Isocudraniaxanthone B
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL199304; 1,5,6-trihydroxy-3-methoxy-4-(2-methylbut-3-en-2-yl)xanthen-9-one; BDBM50175014; ZINC15121022; 1,5,6-trihydroxy-3-methoxy-4-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 132800 nM
|
[3] | ||
Sterol O-acyltransferase 1 |
IC50 = 148000 nM
|
[3] | |||
Compound Name |
Diethyl pyrocarbonate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Diethyl dicarbonate; Diethyl oxydiformate; Diethylpyrocarbonate; Baycovin; Dicarbonic acid, diethyl ester; Ethyl pyrocarbonate; Dicarbonic acid diethyl ester; Diethyl pyrocarbonic acid; Piref; Pyrocarbonic acid diethyl ester; Ethoxyformic acid anhydride; Diethylpyrokarbonat; Oxydiformic acid diethyl ester; Pyrocarbonate d'ethyle; ethoxycarbonyl ethyl carbonate; Pyrokohlensaeure diaethyl ester; Diethylester kyseliny diuhlicite; Pyrocarbonic acid, diethyl ester; Diethyl ester of pyrocarbonic acid; UNII-LMR3LZG146; Dicarbonic acid, 1,3-diethyl ester; MFCD00009106; FORMIC ACID, OXYDI-, DIETHYL ESTER; LMR3LZG146; CHEMBL55517; Dicarbonic acid, C,C'-diethyl ester; Diethyl pyrocarbonate, 97%, pure; Dicarbonate, Diethyl; Oxydiformate, Diethyl; Pyrocarbonate, Diethyl; Anhydride, Ethoxyformic; Diethyldicarbonate; diethyl-pyrocarbonate; Pyrocarbonate d''ethyle; ACMC-1BPPN; ethoxycarbonyl ethoxyformate; DEPC (Diethylpyrocarbonate); diethyl pyrocarbonate (depc); Diethyl pyrocarbonate, 97%; DSSTox_CID_30319; DSSTox_GSID_51764; SCHEMBL15582; 4-03-00-00018 (Beilstein Handbook Reference); KSC489Q5R; DTXSID2051764; CTK3I9858; 3,3',5,5'-tetraethylbenzidine; Diethyl pyrocarbonate, 99% (NT); KS-00000G1H; ZINC8419346; Tox21_303976; 8132AA; BDBM50035000; AKOS015900388; Diethyl pyrocarbonate, >=97% (NMR); MCULE-5668620613; carbonic acid, ethoxycarbonyl ethyl ester; NCGC00357200-01; AK114461; AS-10585; SC-91610; CARBONIC ACID,ETHYL ESTER,ANHYDRIDE; FT-0657552; ST51037226; DIETHYLPYROCARBONATE HI-PU GRADE 100G; A21658; C11592; Diethyl pyrocarbonate, purum, >=97.0% (NT); K-5044; 47626-EP2284169A1; 47626-EP2287161A1; 47626-EP2287162A1; 47626-EP2305643A1; 47626-EP2311811A1; 47626-EP2374454A1; 609D478; Q421385; J-200332; Diethyl pyrocarbonate, Vetec(TM) reagent grade, >=97%
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 170000 nM
|
[8] | ||
Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
---|---|---|---|---|---|
Compound Name |
Octanoic acid biphenyl-2-ylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL408322; octanoic acid biphenyl-2-ylamide; SCHEMBL15472053
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 230000 nM
|
[1] | ||
Compound Name |
Nonanoic acid biphenyl-2-ylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL270041; nonanoic acid biphenyl-2-ylamide; SCHEMBL15472054
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 2 |
IC50 = 414000 nM
|
[1] | ||
Compound Name |
LINOLEIC ACID
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
linoleic acid; 60-33-3; Linolic acid; Telfairic acid; (9Z,12Z)-octadeca-9,12-dienoic acid; cis,cis-Linoleic acid; Grape seed oil; Linoleate; cis,cis-9,12-Octadecadienoic acid; Emersol 315; cis-9,cis-12-Octadecadienoic acid; 9,12-Linoleic acid; Unifac 6550; 9Z,12Z-Linoleic acid; Extra Linoleic 90; 9-cis,12-cis-Linoleic acid; Polylin 515; Emersol 310; Polylin No. 515; Oils, grape; 9Z,12Z-octadecadienoic acid; alpha-Linoleic acid; all-cis-9,12-Octadecadienoic acid; Linoleic; acide linoleique; (Z,Z)-9,12-Octadecadienoic acid; acido lino
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 > 1000000 nM
|
[5] | ||
Compound Name |
OLEIC ACID
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
oleic acid; 112-80-1; cis-9-Octadecenoic acid; cis-Oleic acid; Elaidoic acid; oleate; Glycon wo; Wecoline OO; Pamolyn 100; Glycon RO; (Z)-Octadec-9-enoic acid; Metaupon; Oelsauere; Vopcolene 27; Groco 5l; Groco 2; Groco 4; Groco 6; Tego-oleic 130; Emersol 211; Z-9-Octadecenoic acid; Industrene 206; Industrene 105; Pamolyn; Industrene 205; Oleinic acid; Emersol 213; Emersol 210; L'Acide oleique; cis-Octadec-9-enoic acid; Century cd fatty acid; Emersol 6321; Extraolein 90; Oleine 7503; 9-Octadecenoic acid (Z)-; Emersol 205; Emersol 233LL
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 > 1000000 nM
|
[5] | ||
Compound Name |
1-[5-[(5-Phenylpyridazine-3-yl)amino]pentyl]-1-heptyl-3-(2,4-difluorophenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL383811; BDBM50177893; N-(2,4-difluorophenyl)-N''-heptyl-N''-{5-[(5-phenyl-pyridazin-3-yl)amino]pentyl}urea
Click to Show/Hide
|
||||
Activity | Sterol O-acyltransferase 1 |
IC50 = 414000 nM
|
[14] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | US patent application no. 9149492B2, Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease | ||||
REF 2 | Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor. Bioorg Med Chem Lett. 2000 Jun 19;10(12):1315-6. | ||||
REF 3 | Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5580-3. | ||||
REF 4 | Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors. J Med Chem. 2008 Mar 13;51(5):1474-7. | ||||
REF 5 | Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80. | ||||
REF 6 | Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):385-8. | ||||
REF 7 | Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2. Bioorg Med Chem Lett. 2013 May 1;23(9):2659-62. | ||||
REF 8 | US patent application no. 20140308340A1, METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ||||
REF 9 | Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors. Eur J Med Chem. 2013 Apr;62:515-25. | ||||
REF 10 | Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4677-81. | ||||
REF 11 | Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(7):2433-46. | ||||
REF 12 | Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3798-801. | ||||
REF 13 | Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem. 2012 Dec 13;55(23):10610-29. | ||||
REF 14 | Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors. J Med Chem. 2005 Dec 1;48(24):7708-13. | ||||
REF 15 | Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor. J Med Chem. 2018 Dec 13;61(23):10635-10650. | ||||
REF 16 | Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3109-12. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.