Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T66935 | Target Info | |||
Target Name | Poly [ADP-ribose] glycohydrolase (PARG) | ||||
Synonyms |
Poly(ADP-ribose) glycohydrolase
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Target Type | Literature-reported Target | ||||
Gene Name | PARG | ||||
Biochemical Class | Glycosylase | ||||
UniProt ID |
Poor Binders of This Target (in total, 25 binders) | Download | Top | |||
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Compound Name |
Chembl4291914
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Investigative | Compound Info | ||
Synonyms |
BDBM50466569; AB00007603-01
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Activity |
EC50 ~ 50000 nM
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[1] | |||
Compound Name |
2-Phenanthridinesulfonamide, N-cyclopropyl-5,6-dihydro-6-oxo-
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3115335; ZINC4632182; BDBM50466567; STK735113; AKOS000646190; MCULE-6712223956; ST4129266; 2-[(cyclopropylamino)sulfonyl]-5-hydrophenanthridin-6-one; N-cyclopropyl-6-oxo-5,6-dihydro-2-phenanthridinesulfonamide; N-cyclopropyl-6-oxo-5,6-dihydrophenanthridine-2-sulfonamide
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Activity |
EC50 = 50000 nM
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[1] | |||
Compound Name |
Chembl4284330
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Investigative | Compound Info | ||
Synonyms |
ZINC4744064; BDBM50466595; STK737404; AKOS001727009; MCULE-6475683435; ST093211; 6-{[(tert-butyl)amino]sulfonyl}-1,4-dimethylhydroquinolin-2-one; N-tert-butyl-1,4-dimethyl-2-oxo-1,2-dihydroquinoline-6-sulfonamide; N-(tert-butyl)-1,4-dimethyl-2-oxo-1,2-dihydroquinoline-6-sulfonamide
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Activity |
EC50 = 57000 nM
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[1] | |||
Compound Name |
3,5-Dichloro-N-(3-chloro-4-phenoxyphenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1814047; BDBM50350105
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Activity |
IC50 = 61000 nM
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[2] | |||
Compound Name |
3-Chloro-N-(3-chloro-4-naphthalen-2-yloxyphenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1813885; BDBM50350098
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Activity |
IC50 = 61000 nM
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[2] | |||
Compound Name |
3,5-Dichloro-N-(3-chloro-4-naphthalen-2-yloxyphenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1813881; BDBM50350095
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Activity |
EC50 ~ 70000 nM
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[1] | |||
Compound Name |
3-{(5z)-5-[5-Chloro-1-(2,6-Dichlorobenzyl)-2-Oxo-1,2-Dihydro-3h-Indol-3-Ylidene]-4-Oxo-2-Thioxo-1,3-Thiazolidin-3-Yl}propanoic Acid
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Investigative | Compound Info | ||
Synonyms |
rbpi-3; CHEMBL4288328; BDBM50466568; ZINC98207857; Q27451356
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Activity |
EC50 ~ 70000 nM
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[1] | |||
Compound Name |
2-[(3-Chloro-4-naphthalen-2-yloxyphenyl)carbamoyl]benzoic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1813887; BDBM50350109
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Activity |
IC50 = 72000 nM
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[2] | |||
Compound Name |
2-{[(Tert-butyl)amino]sulfonyl}anthracene-9,10-dione
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Investigative | Compound Info | ||
Synonyms |
CBDivE_012586; CHEMBL4290650; SCHEMBL15705228; BDBM205478; ZINC3901019; 9,10-Dioxo-9,10-dihydro-anthracene-2-sulfonic acid tert-butylamide; AKOS000521043; MCULE-3185420754; EU-0073591; PDD00013907 (1); ST50337519; AB00074273-01; SR-01000908181; SR-01000908181-1; F0919-0881; N-(tert-butyl)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonamide
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Activity |
EC50 = 81000 nM
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[1] | |||
Compound Name |
Chembl4286999
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Investigative | Compound Info | ||
Synonyms |
BDBM50466570
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Activity |
EC50 = 88000 nM
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[1] | |||
Compound Name |
Chembl4279825
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Investigative | Compound Info | ||
Synonyms |
BDBM50466583
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Activity |
EC50 = 110000 nM
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[1] | |||
Compound Name |
Chembl4294973
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Investigative | Compound Info | ||
Synonyms |
BDBM50466596; ZINC33077128; MCULE-5498363111; BRD-K56113534-001-01-2; N-(tert-butyl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide
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Activity |
EC50 = 110000 nM
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[1] | |||
Compound Name |
Chembl4287243
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Investigative | Compound Info | ||
Synonyms |
BDBM50466600; ZINC10435028; AKOS024480327; MCULE-8624158852; F3211-0002; N-ethyl-9,10-dioxo-9,10-dihydroanthracene-2-sulfonamide
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Activity |
EC50 = 110000 nM
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[1] | |||
Compound Name |
5-Chloro-N-(3-chloro-4-naphthalen-2-yloxyphenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1813884; BDBM50350097
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Activity |
IC50 = 117000 nM
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[2] | |||
Compound Name |
N,1,3-Triethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3445463; ZINC6046683; BDBM50466599; AKOS003277972; MCULE-5167460537
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Activity |
EC50 = 140000 nM
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[1] | |||
Compound Name |
3,5-Dichloro-N-(3-chloro-4-naphthalen-2-yloxyphenyl)-2-hydroxy-N-methylbenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1813890; BDBM50350099
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Activity |
IC50 = 140000 nM
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[2] | |||
Compound Name |
N-Ethyl-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL4291377; Oprea1_344432; ZINC1440297; BBL009025; BDBM50466580; MFCD02604473; STK381907; AKOS003390424; MCULE-8480716948
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
Chembl4279279
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Investigative | Compound Info | ||
Synonyms |
BDBM50466598
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
Chembl4287896
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Investigative | Compound Info | ||
Synonyms |
BDBM50466584
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
Chembl4278137
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Investigative | Compound Info | ||
Synonyms |
BDBM50466601
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
Chembl4287526
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Investigative | Compound Info | ||
Synonyms |
N-(2-hydroxyethyl)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonamide; ZINC4181437; BDBM50466579; AKOS001694358; MCULE-9845968537; AE-848/00996027; SR-01000086284; SR-01000086284-1; F1414-0254; N-(2-hydroxyethyl)-9,10-dioxo-9,10-dihydro-2-anthracenesulfonamide
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
Chembl4287413
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Investigative | Compound Info | ||
Synonyms |
BDBM50466602
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
Chembl4294224
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Investigative | Compound Info | ||
Synonyms |
BDBM50466573
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
Chembl4283645
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Investigative | Compound Info | ||
Synonyms |
ZINC4276424; BDBM50466566; AKOS024608605; MCULE-4127231164; F1414-0255; N-(2-methoxyethyl)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonamide
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Compound Name |
N-Tert-butylnaphthalene-2-sulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL4291566; CBMicro_045156; Oprea1_229532; SCHEMBL12622308; ZINC441625; BDBM50466582; STK202226; AKOS003040897; MCULE-9251571117; BIM-0045423.P001; SR-01000227907; SR-01000227907-1
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Activity |
EC50 ~ 150000 nM
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[1] | |||
Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
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Compound Name |
3,5-Dichloro-N-(3-chlorophenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1814051; Benzamide, 3,5-dichloro-N-(3-chlorophenyl)-2-hydroxy-; SCHEMBL8672680; DTXSID00210288; BDBM50350106
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Activity |
IC50 = 500000 nM
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[2] | |||
Compound Name |
N-(3-Chloro-4-naphthalen-2-yloxyphenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1813883; BDBM50350096
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Activity |
IC50 = 500000 nM
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[2] | |||
Compound Name |
Benzamide
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Investigative | Compound Info | ||
Synonyms |
Benzoylamide; Benzoic acid amide; Phenylcarboxyamide; Phenylcarboxamide; Benzenecarboxamide; Amid kyseliny benzoove; Amid kyseliny benzoove [Czech]; NSC 3114; MFCD00007968; Phenyl Carboxyamide; Benzamide, 99%; BENZOIC ACID,AMIDE; UNII-6X80438640; CHEMBL267373; 6X80438640; CCRIS 4594; HSDB 6360; EINECS 200-227-7; benzeneamide; benzimide; BRN 0385876; N-benzoylamine; benzoyl nitrogen; AI3-01031; benzene carboxamide; benzene-carboxamide; WLN: ZVR; benzene carboximidoic acid; PhC(O)NH2; Lopac-B-2009; ACMC-1AZ9T; DSSTox_CID_1709; bmse000668; PhC(=O)NH2; DSSTox_RID_76288; DSSTox_GSID_21709; Lopac0_000160; SCHEMBL16352; 4-09-00-00725 (Beilstein Handbook Reference); benzamide (ACD/Name 4.0); KSC175C0F; MLS000069472; Benzamide, p.a., 98.0%; ARONIS003511; DTXSID0021709; KS-00000FOV; KS-00003WHQ; NSC3114; HMS2231M11; HMS3260O22; HMS3371I16; HMS3885L18; ZINC152996; CS-Z0019; HY-Z0283; NSC-3114; Tox21_200621; Tox21_500160; ANW-32259; BDBM50106187; s4715; SBB058198; STK069333; AKOS000118773; CCG-204255; LP00160; MCULE-2811211507; SDCCGSBI-0050148.P002; Benzamide, purum, >=98.0% (HPLC); NCGC00015142-01; NCGC00015142-02; NCGC00015142-03; NCGC00015142-04; NCGC00015142-05; NCGC00015142-06; NCGC00015142-07; NCGC00091355-01; NCGC00091355-02; NCGC00091355-03; NCGC00258175-01; NCGC00260845-01; AK-77684; BP-21224; DS-17194; SC-26846; SMR000059089; SY047098; Benzamide, Vetec(TM) reagent grade, 98%; B0012; B0220; EU-0100160; FT-0622630; FT-0622631; ST45040306; AZ0001-0025; B 2009; Benzamide, purified by sublimation, >=99.5%; C09815; M-4040; 12078-EP2272827A1; 12078-EP2275469A1; 12078-EP2284157A1; 12078-EP2284169A1; 12078-EP2287161A1; 12078-EP2287162A1; 12078-EP2287940A1; 12078-EP2289894A2; 12078-EP2289965A1; 12078-EP2292593A2; 12078-EP2295061A1; 12078-EP2295402A2; 12078-EP2295413A1; 12078-EP2295421A1; 12078-EP2295424A1; 12078-EP2295550A2; 12078-EP2298076A1; 12078-EP2298077A1; 12078-EP2298731A1; 12078-EP2298828A1; 12078-EP2300455A2; 12078-EP2301353A1; 12078-EP2301929A1; 12078-EP2301935A1; 12078-EP2301983A1; 12078-EP2305031A1; 12078-EP2305034A1; 12078-EP2305035A1; 12078-EP2305662A1; 12078-EP2305674A1; 12078-EP2305687A1; 12078-EP2308848A1; 12078-EP2308858A1; 12078-EP2311494A1; 12078-EP2314583A1; 12078-EP2314585A1; 12078-EP2316825A1; 12078-EP2316831A1; 12078-EP2371810A1; 74166-EP2308857A1; A830526; Q417731; SR-01000075601; SR-01000075601-1; F3145-2903; Sulfabenzamide; Sulfabenzid; Sulfabenzide; Sulfabenzoylamide; N-Sulfamylbenzamide
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Activity |
IC50 > 1000000 nM
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[2] |
References | Top | ||||
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REF 1 | Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. J Med Chem. 2018 Dec 13;61(23):10767-10792. | ||||
REF 2 | Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). J Med Chem. 2011 Aug 11;54(15):5403-13. |
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