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Target General Information |
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Target ID |
T87871 |
Target Info
|
Target Name |
Neurotrophic tyrosine kinase ROR1 (ROR1) |
Synonyms |
receptor tyrosine kinase-like orphan receptor 1; receptor tyrosine kinase like orphan receptor 1; neurotrophic tyrosine kinase, receptor-related 1; dJ537F10.1; Tyrosine-protein kinase transmembrane receptor ROR1; NTRKR1; Inactive tyrosine-protein kinase transmembrane receptor ROR1 |
Target Type |
Clinical trial Target |
Gene Name |
ROR1 |
Biochemical Class |
Kinase |
UniProt ID |
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Targeted Antigens of CAR-T Cell Therapy |
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CAR T-Cell Therapy Drug(s) |
ROR1 CAR-specific Autologous T-Lymphocytes |
Drug Info
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Phase 1 |
Mantle cell lymphoma |
[1] |
ROR1R-CAR-T Cell |
Drug Info
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Phase 1 |
leukaemia |
[2] |
References |
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REF 1 |
ClinicalTrials.gov (NCT02706392) Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies
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REF 2 |
ClinicalTrials.gov (NCT02194374) Autologous ROR1R-CAR-T Cells for Chronic Lymphocytic Leukemia (CLL)
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