Target General Information
Target ID T93923 Target Info
Target Name Co-stimulatory molecule 4-1BB (CD137)
Synonyms Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA; T-cell antigen 4-1BB homolog; ILA; CDw137; 4-1BB ligand receptor
Target Type Clinical trial Target
Gene Name TNFRSF9
Biochemical Class Cytokine receptor
UniProt ID
Targeted Antigens of CAR-T Cell Therapy
CAR T-Cell Therapy Drug(s) CD137 CAR-T Cell Drug Info Phase 1/2 B-cell lymphoma [1]
MG7-CART Drug Info Phase 1/2 Acute myeloid leukaemia [2]
CD28 and CD137 CAR-T Cells Drug Info Phase 1 Acute lymphoblastic leukaemia [3]
References
REF 1 ClinicalTrials.gov (NCT02965092) CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies
REF 2 ClinicalTrials.gov (NCT02862704) A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART)
REF 3 ClinicalTrials.gov (NCT02186860) Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With Acute Lymphoblastic Leukemia

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