Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T85801 | Target Info | |||
Target Name | Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) | ||||
Synonyms | algC; PMM/PGM; PMM / PGM | ||||
Target Type | Literature-reported Target | ||||
Gene Name | Pseudo algC | ||||
Biochemical Class | Intramolecular transferases | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(phosphonooxymethyl)oxan-2-yl] hydrogen phosphate | Ligand Info | |||
Canonical SMILES | C(C1C(C(C(C(O1)OP(=O)(O)[O-])O)O)O)OP(=O)(O)O | ||||
InChI | 1S/C6H14O12P2/c7-3-2(1-16-19(10,11)12)17-6(5(9)4(3)8)18-20(13,14)15/h2-9H,1H2,(H2,10,11,12)(H2,13,14,15)/p-1/t2-,3-,4+,5-,6-/m1/s1 | ||||
InChIKey | RWHOZGRAXYWRNX-VFUOTHLCSA-M | ||||
PubChem Compound ID | 17753989 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 2FKM PMM/PGM S108D mutant with alpha-d-glucose 1,6-bisphosphate bound | ||||||
Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
PDB Sequence |
PASIFRAYDI
19 RGVVGDTLTA29 ETAYWIGRAI39 GSESLARGEP49 CVAVGRDGRL59 SGPELVKQLI 69 QGLVDCGCQV79 SDVGMVPTPV89 LYYAANVLEG99 KSGVMLTGDH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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ARG15
4.449
TYR17
2.519
ASP18
4.141
ARG20
4.469
ASP108
3.056
HIS109
4.255
LYS118
3.163
ASP246
3.903
ARG247
2.965
ASP283
4.873
LYS285
3.478
THR306
3.416
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PDB ID: 2FKF Phosphomannomutase/Phosphoglucomutase from Pseudomonas aeruginosa with alpha-D-glucose 1,6-bisphosphate bound | ||||||
Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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References | Top | ||||
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REF 1 | The reaction of phosphohexomutase from Pseudomonas aeruginosa: structural insights into a simple processive enzyme. J Biol Chem. 2006 Jun 2;281(22):15564-71. |
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