Target General Information
Target ID T00176 Target Info
Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2)
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Target Type Clinical trial Target
Gene Name MDM2
Biochemical Class Acyltransferase
UniProt ID
MDM2_HUMAN 
Target Interacting Proteins
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name X-ray repair cross-complementing protein 6 (XRCC6) Interacting Protein Interacting Protein Info
UniProt ID
XRCC6_HUMAN 
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [2]
4 Reconstituted Complex [2]
Interacting Protein Name Elongation factor 1-alpha 1 (EEF1A1) Interacting Protein Interacting Protein Info
UniProt ID
EF1A1_HUMAN 
Synonyms CCS.3; CCS3; EE1A1; EEF.1; EEF1A; EF.Tu; EF1A; GRAF.1EF; HNGC:16303; LENG7; PTI1; eEF1A.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [4]
Interacting Protein Name Guanine nucleotide-binding protein-like 3 (GNL3) Interacting Protein Interacting Protein Info
UniProt ID
GNL3_HUMAN 
Synonyms C77032; E2IG3; NNP47; NS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-fractionation [8]
Acyltransferases [+] 9 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Protein-peptide [10]
3 Reconstituted Complex [11]
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Biochemical Activity [12]
3 Reconstituted Complex [13]
Interacting Target Name Histone acetyltransferase p300 (EP300) Literature-reported Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Co-fractionation [15]
3 Reconstituted Complex [14]
Interacting Target Name Transcription intermediary factor 1-beta (TRIM28) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1B_HUMAN 
Synonyms Tripartite motif-containing protein 28; TIF1-beta; TIF1B; RNF96; RING-type E3 ubiquitin transferase TIF1-beta; RING finger protein 96; Nuclear corepressor KAP-1; KRIP-1; KRAB-interacting protein 1; KRAB-associated protein 1; KAP-1; KAP1; E3 SUMO-protein ligase TRIM28
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [16]
Interacting Protein Name Histone acetyltransferase KAT5 (KAT5) Interacting Protein Interacting Protein Info
UniProt ID
KAT5_HUMAN 
Synonyms ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5; cPLA2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Interacting Protein Name E3 ubiquitin-protein ligase RBBP6 (RBBP6) Interacting Protein Interacting Protein Info
UniProt ID
RBBP6_HUMAN 
Synonyms P2P.R; PACT; RBQ.1; SNAMA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [20]
Interacting Protein Name Transcription initiation factor TFIID subunit 1 (TAF1) Interacting Protein Interacting Protein Info
UniProt ID
TAF1_HUMAN 
Synonyms BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4; N.TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A; TAFII.250; TAFII250; XDP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [22]
Interacting Protein Name NEDD8-conjugating enzyme Ubc12 (UBE2M) Interacting Protein Interacting Protein Info
UniProt ID
UBC12_HUMAN 
Synonyms UBC.RS2; UBC12; hUbc12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Reconstituted Complex [24]
Interacting Protein Name RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) Interacting Protein Interacting Protein Info
UniProt ID
ZN363_HUMAN 
Synonyms ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Reconstituted Complex [26]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Co-localization [28]
3 Reconstituted Complex [27]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Affinity Capture-Western [30]
3 Fluorescence Resonance Energy Transfer [31]
4 Protein-peptide [32]
5 Reconstituted Complex [30]
Heat shock proteins [+] 3 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [33]
3 Co-purification [34]
4 Protein-peptide [35]
5 Reconstituted Complex [34]
Interacting Target Name Endoplasmin (HSP90B1) Clinical trial Target Interacting Protein Info
UniProt ID
ENPL_HUMAN 
Synonyms Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP-94; GRP94; gp96 homolog; 94 kDa glucose-regulated protein; 94 kDa glucoseregulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Reconstituted Complex [37]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [33]
Isomerases [+] 1 Isomerases +
Interacting Target Name DNA topoisomerase I (TOP1) Successful Target Interacting Protein Info
UniProt ID
TOP1_HUMAN 
Synonyms DNA topoisomerase I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [38]
Kinases [+] 12 Kinases +
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Biochemical Activity [39]
3 Protein-peptide [23]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Clinical trial Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [40]
2 Biochemical Activity [41]
3 Co-localization [42]
Interacting Target Name Telomerase reverse transcriptase (TERT) Clinical trial Target Interacting Protein Info
UniProt ID
TERT_HUMAN 
Synonyms TRT; TP2; Telomerase-associated protein 2; Telomerase catalytic subunit; TCS1; HEST2; EST2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Biochemical Activity [43]
3 Reconstituted Complex [43]
Interacting Target Name Insulin-like growth factor I receptor (IGF1R) Successful Target Interacting Protein Info
UniProt ID
IGF1R_HUMAN 
Synonyms Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Biochemical Activity [45]
Interacting Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target Interacting Protein Info
UniProt ID
CHK2_HUMAN 
Synonyms Hucds1; hCds1; CHK2 checkpoint homolog; CHK2; Checkpoint kinase 2; Cds1 homolog; Cds1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [46]
2 Reconstituted Complex [47]
Interacting Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Interacting Protein Info
UniProt ID
PIM1_HUMAN 
Synonyms PIM; Pim-1 proto-oncogene, serine/threonine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Biochemical Activity [49]
Interacting Target Name Beta-adrenergic receptor kinase 1 (ADRBK1) Patented-recorded Target Interacting Protein Info
UniProt ID
ARBK1_HUMAN 
Synonyms GRK2; G-protein coupled receptor kinase 2; Beta-ARK-1; BetaARK1; Beta ARK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [50]
2 Affinity Capture-Western [51]
Interacting Target Name Death-associated protein kinase 3 (DAPK3) Literature-reported Target Interacting Protein Info
UniProt ID
DAPK3_HUMAN 
Synonyms Zipper-interacting protein kinase; ZIP-kinase; ZIPK; MYPT1 kinase; Dlk; DAP-like kinase; DAP kinase 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [35]
2 Co-localization [52]
Interacting Target Name Casein kinase I delta (CSNK1D) Literature-reported Target Interacting Protein Info
UniProt ID
KC1D_HUMAN 
Synonyms Tau-protein kinase CSNK1D; HCKID; CKI-delta; CKId; Casein kinase I isoform delta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Biochemical Activity [54]
Interacting Target Name Homeodomain interacting protein kinase 2 (HIPK2) Literature-reported Target Interacting Protein Info
UniProt ID
HIPK2_HUMAN 
Synonyms Homeodomain-interacting protein kinase 2; hHIPk2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [55]
2 Biochemical Activity [56]
Interacting Protein Name Serine/threonine-protein kinase PAK 6 (PAK6) Interacting Protein Interacting Protein Info
UniProt ID
PAK6_HUMAN 
Synonyms PAK5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [58]
Interacting Target Name Pyruvate kinase M2 (PKM) Clinical trial Target Interacting Protein Info
UniProt ID
KPYM_HUMAN 
Synonyms Tumor M2-PK; Thyroid hormone-binding protein 1; THBP1; Pyruvate kinase PKM; Pyruvate kinase muscle isozyme; Pyruvate kinase isozymes M1/M2; Pyruvate kinase 2/3; PKM2; PK3; PK2; p58; Opa-interacting protein 3; OIP-3; OIP3; Cytosolic thyroid hormone-binding protein; CTHBP
Evidence Score (E-score) 1 Experimental Evidences +
1 Reconstituted Complex [37]
Nuclear hormone receptors [+] 3 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Biochemical Activity [59]
3 Co-localization [28]
4 Reconstituted Complex [60]
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [61]
2 Reconstituted Complex [61]
3 Yeast two hybrid [62]
Interacting Target Name Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B2_HUMAN 
Synonyms Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Co-localization [64]
Peptidases [+] 3 Peptidases +
Interacting Target Name Herpesvirus ubiquitin-specific protease (HAUSP) Patented-recorded Target Interacting Protein Info
UniProt ID
UBP7_HUMAN 
Synonyms Ubiquitin-specific-processing protease 7; Ubiquitin thioesterase 7; Ubiquitin carboxyl-terminal hydrolase 7; Herpesvirus-associated ubiquitin-specific protease; Deubiquitinating enzyme 7
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [65]
3 Co-crystal Structure [66]
4 Co-fractionation [67]
5 Protein-peptide [67]
6 Reconstituted Complex [68]
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [69]
2 Co-localization [42]
Interacting Protein Name Proteasome subunit alpha type-7 (PSMA7) Interacting Protein Interacting Protein Info
UniProt ID
PSA7_HUMAN 
Synonyms C6; HSPC; RC6.1; XAPC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [70]
2 Co-fractionation [8]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [72]
3 Co-crystal Structure [73]
4 Co-fractionation [14]
5 Protein-Fragment Complementation Assay [74]
6 Reconstituted Complex [71]
Proteasome components [+] 1 Proteasome components +
Interacting Protein Name Proteasome 26S subunit non-ATPase 4 (PSMD4) Interacting Protein Interacting Protein Info
UniProt ID
PSMD4_HUMAN 
Synonyms AF; AF.1; ASF; MCB1; Rpn10; S5A; pUB.R5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [75]
Proteins 14-3-3 [+] 2 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein sigma (SFN) Interacting Protein Interacting Protein Info
UniProt ID
1433S_HUMAN 
Synonyms YWHAS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [76]
2 Reconstituted Complex [76]
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Reconstituted Complex [78]
Ribosomal proteins [+] 6 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein uL5 (RPL11) Interacting Protein Interacting Protein Info
UniProt ID
RL11_HUMAN 
Synonyms DBA7; GIG34; L11
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [79]
2 Affinity Capture-Western [80]
3 Co-fractionation [81]
4 Co-purification [82]
5 Reconstituted Complex [83]
6 Yeast two hybrid [84]
Interacting Protein Name Large ribosomal subunit protein uL24 (RPL26) Interacting Protein Interacting Protein Info
UniProt ID
RL26_HUMAN 
Synonyms DBA11; L26
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [85]
2 Biochemical Activity [86]
3 Co-localization [85]
4 Reconstituted Complex [85]
5 Yeast two hybrid [85]
Interacting Protein Name Large ribosomal subunit protein uL14 (RPL23) Interacting Protein Interacting Protein Info
UniProt ID
RL23_HUMAN 
Synonyms L23; rpL17
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [79]
2 Affinity Capture-Western [87]
3 Co-fractionation [88]
4 Reconstituted Complex [88]
Interacting Protein Name Large ribosomal subunit protein uL18 (RPL5) Interacting Protein Interacting Protein Info
UniProt ID
RL5_HUMAN 
Synonyms DBA6; L5; PPP1R135
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [79]
2 Affinity Capture-Western [89]
3 Co-fractionation [81]
4 Reconstituted Complex [83]
Interacting Protein Name Small ribosomal subunit protein eS7 (RPS7) Interacting Protein Interacting Protein Info
UniProt ID
RS7_HUMAN 
Synonyms DBA8; S7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [90]
2 Reconstituted Complex [90]
3 Yeast two hybrid [90]
Interacting Protein Name Small ribosomal subunit protein uS10 (RPS20) Interacting Protein Interacting Protein Info
UniProt ID
RS20_HUMAN 
Synonyms S20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [91]
Transcription regulators [+] 14 Transcription regulators +
Interacting Target Name Interferon regulatory factor 1 (IRF1) Literature-reported Target Interacting Protein Info
UniProt ID
IRF1_HUMAN 
Synonyms IRF-1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [92]
2 Biochemical Activity [93]
3 Protein-peptide [38]
4 Reconstituted Complex [93]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [94]
2 Biochemical Activity [95]
3 Reconstituted Complex [96]
Interacting Protein Name Tumor protein p73 (TP73) Interacting Protein Interacting Protein Info
UniProt ID
P73_HUMAN 
Synonyms P73
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [97]
2 Biochemical Activity [98]
3 Reconstituted Complex [99]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [100]
2 Reconstituted Complex [100]
3 Yeast two hybrid [84]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [101]
2 Biochemical Activity [102]
Interacting Target Name Notch-1 receptor (NOTCH1) Clinical trial Target Interacting Protein Info
UniProt ID
NOTC1_HUMAN 
Synonyms Translocation-associated notch protein TAN-1; Translocationassociated notch protein TAN1; TAN1; Notch 1 intracellular domain; Notch 1; NICD; Neurogenic locus notch homolog protein 1; hN1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [103]
2 Biochemical Activity [104]
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [105]
2 Biochemical Activity [106]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [107]
2 Yeast two hybrid [84]
Interacting Target Name Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) Literature-reported Target Interacting Protein Info
UniProt ID
ATF3_HUMAN 
Synonyms Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [108]
2 Reconstituted Complex [108]
Interacting Protein Name Forkhead box protein O4 (FOXO4) Interacting Protein Interacting Protein Info
UniProt ID
FOXO4_HUMAN 
Synonyms AFX; AFX1; MLLT7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [109]
2 Biochemical Activity [109]
Interacting Protein Name General transcription factor II-I (GTF2I) Interacting Protein Interacting Protein Info
UniProt ID
GTF2I_HUMAN 
Synonyms BAP135; BTKAP1; DIWS; GTFII.I; IB291; SPIN; TFII.I; WBS; WBSCR6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [110]
Interacting Protein Name Interferon regulatory factor 2 (IRF2) Interacting Protein Interacting Protein Info
UniProt ID
IRF2_HUMAN 
Synonyms IRF.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [111]
2 Protein-peptide [38]
Interacting Protein Name Tumor protein 63 (TP63) Interacting Protein Interacting Protein Info
UniProt ID
P63_HUMAN 
Synonyms AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [112]
2 Reconstituted Complex [113]
Interacting Protein Name Forkhead box protein O3 (FOXO3) Interacting Protein Interacting Protein Info
UniProt ID
FOXO3_HUMAN 
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-Western [114]
Ubiquitin related proteins [+] 4 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-40S ribosomal protein S27a (RPS27A) Interacting Protein Interacting Protein Info
UniProt ID
RS27A_HUMAN 
Synonyms CEP80; HEL112; S27A; UBA80; UBC; UBCEP1; UBCEP80
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [115]
2 Biochemical Activity [115]
3 Yeast two hybrid [84]
Interacting Protein Name Ubiquitin conjugation factor E4 B (UBE4B) Interacting Protein Interacting Protein Info
UniProt ID
UBE4B_HUMAN 
Synonyms E4; HDNB1; UBOX3; UFD2; UFD2A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [116]
2 Co-fractionation [117]
3 Reconstituted Complex [117]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [118]
2 Reconstituted Complex [119]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [120]
2 Reconstituted Complex [121]
Other proteins [+] 15 Other proteins +
Interacting Target Name p53-binding protein Mdm4 (MDM4) Clinical trial Target Interacting Protein Info
UniProt ID
MDM4_HUMAN 
Synonyms Protein Mdmx; p53-binding protein Mdm4; Mdm2-like p53-binding protein; Double minute 4 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [122]
3 Co-crystal Structure [123]
4 Protein-peptide [124]
5 Reconstituted Complex [125]
6 Yeast two hybrid [84]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [126]
2 Biochemical Activity [127]
3 Co-localization [128]
4 Yeast two hybrid [127]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [129]
3 Fluorescence Resonance Energy Transfer [130]
4 Reconstituted Complex [129]
Interacting Protein Name Protein numb homolog (NUMB) Interacting Protein Interacting Protein Info
UniProt ID
NUMB_HUMAN 
Synonyms C14orf41; S171; c14_5527
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [131]
3 Reconstituted Complex [131]
4 Yeast two hybrid [132]
Interacting Target Name Nucleolin (NCL) Clinical trial Target Interacting Protein Info
UniProt ID
NUCL_HUMAN 
Synonyms Protein C23; Nucleolin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [133]
3 Reconstituted Complex [37]
Interacting Protein Name Mdm2-binding protein (MTBP) Interacting Protein Interacting Protein Info
UniProt ID
MTBP_HUMAN 
Synonyms MDM2BP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [134]
2 Reconstituted Complex [134]
3 Yeast two hybrid [134]
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [135]
2 Reconstituted Complex [136]
Interacting Target Name Beta-arrestin-1 (ARRB1) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB1_HUMAN 
Synonyms Non-visual arrestin-2; Betaarrestin1; Arrestin beta-1; Arrestin beta1; ARR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [137]
2 Yeast two hybrid [127]
Interacting Target Name Epithelial cadherin (CDH1) Literature-reported Target Interacting Protein Info
UniProt ID
CADH1_HUMAN 
Synonyms Uvomorulin; UVO; E-cadherin gene; E-cadherin; CDHE; CD324; CAM 120/80; Cadherin-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [138]
2 Reconstituted Complex [138]
Interacting Target Name Gankyrin (PSMD10) Literature-reported Target Interacting Protein Info
UniProt ID
PSD10_HUMAN 
Synonyms p28(GANK); 26S proteasome regulatory subunit p28; 26S proteasome non-ATPase regulatory subunit 10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [119]
2 Reconstituted Complex [139]
Interacting Protein Name Nibrin (NBN) Interacting Protein Interacting Protein Info
UniProt ID
NBN_HUMAN 
Synonyms AT.V1; AT.V2; ATV; NBS; NBS1; P95
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [140]
2 Affinity Capture-Western [140]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [141]
2 Reconstituted Complex [142]
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [143]
2 Reconstituted Complex [144]
Interacting Protein Name Polycomb protein SUZ12 (SUZ12) Interacting Protein Interacting Protein Info
UniProt ID
SUZ12_HUMAN 
Synonyms CHET9; JJAZ1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [57]
2 Affinity Capture-Western [145]
Interacting Protein Name Nucleolar transcription factor 1 (UBTF) Interacting Protein Interacting Protein Info
UniProt ID
UBF1_HUMAN 
Synonyms NOR.90; UBF; UBF.1; UBF1; UBF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [20]
2 Protein-peptide [38]
References
REF 1 Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator. PLoS One. 2013 Oct 11;8(10):e77643.
REF 2 Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization. Cell Death Differ. 2009 May;16(5):758-69.
REF 3 HDM2-binding partners: interaction with translation elongation factor EF1alpha. J Proteome Res. 2007 Apr;6(4):1410-7.
REF 4 Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 2012 Dec 21;151(7):1581-94.
REF 5 Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF. Oncogene. 2015 Mar 26;34(13):1688-97.
REF 6 Nucleoplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survival. J Cell Sci. 2008 Dec 15;121(Pt 24):4037-46.
REF 7 Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability. FEBS Lett. 2012 Jul 30;586(16):2225-31.
REF 8 Mdm2 facilitates the association of p53 with the proteasome. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10038-43.
REF 9 XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J. 2013 Aug 14;32(16):2204-16.
REF 10 Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. Mol Cancer. 2015 Mar 26;14:65.
REF 11 Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell. 2009 May 5;15(5):363-75.
REF 12 MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation. J Biol Chem. 2004 May 7;279(19):20035-43.
REF 13 MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem. 2002 Aug 23;277(34):30838-43.
REF 14 p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell. 1998 Oct;2(4):405-15.
REF 15 MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12547-52.
REF 16 MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J. 2005 Sep 21;24(18):3279-90.
REF 17 Specific inhibition of Mdm2-mediated neddylation by Tip60. Cell Cycle. 2008 Jan 15;7(2):222-31.
REF 18 Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J. 2002 Apr 2;21(7):1704-12.
REF 19 PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7951-6.
REF 20 Screening E3 substrates using a live phage display library. PLoS One. 2013 Oct 4;8(10):e76622.
REF 21 Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53. Oncogene. 2007 Jun 21;26(29):4234-42.
REF 22 The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter. J Biol Chem. 1997 Dec 5;272(49):30651-61.
REF 23 Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1749-54.
REF 24 Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell. 2004 Jul 9;118(1):83-97.
REF 25 Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53. Mol Biol Rep. 2011 Jan;38(1):229-36.
REF 26 Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J Biol Chem. 2009 Aug 14;284(33):21955-70.
REF 27 MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J. 2002 Nov 15;21(22):6236-45.
REF 28 Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation. Nucleic Acids Res. 2005 Jan 7;33(1):13-26.
REF 29 Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003 Dec;23(23):8902-12.
REF 30 Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2. Oncogene. 2002 Jul 4;21(29):4498-507.
REF 31 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 32 An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene. 2000 May 4;19(19):2312-23.
REF 33 Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy. Biochem Biophys Res Commun. 2010 Jul 16;398(1):26-31.
REF 34 Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. J Mol Biol. 2004 Mar 12;337(1):129-45.
REF 35 Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. J Mol Biol. 2004 Mar 12;337(1):115-28.
REF 36 Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. Cancer Lett. 2015 Apr 10;359(2):325-34.
REF 37 A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One. 2010 Feb 24;5(2):e9289.
REF 38 A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2. Cell Signal. 2014 Jun;26(6):1243-57.
REF 39 Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J. 2002 Jul 15;21(14):3715-27.
REF 40 HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol. 2001 Nov;3(11):973-82.
REF 41 Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem. 2002 Jun 14;277(24):21843-50.
REF 42 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 43 Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT. Oncogene. 2010 Jul 15;29(28):4101-12.
REF 44 Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8247-52.
REF 45 Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. Cancer Res. 2008 Jul 15;68(14):5669-77.
REF 46 Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities. Cell Cycle. 2009 Feb 1;8(3):430-7.
REF 47 HDM2 negatively affects the Chk2-mediated phosphorylation of p53. FEBS Lett. 2005 May 9;579(12):2604-8.
REF 48 Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. J Biol Chem. 2008 Jun 27;283(26):18012-23.
REF 49 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF). FEBS Lett. 2009 Feb 18;583(4):615-20.
REF 50 The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Glia. 2015 Dec;63(12):2327-39.
REF 51 Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2. J Biol Chem. 2011 Jan 14;286(2):1165-73.
REF 52 Zipper-interacting protein kinase is involved in regulation of ubiquitination of the androgen receptor, thereby contributing to dynamic transcription complex assembly. Oncogene. 2013 Oct 10;32(41):4981-8.
REF 53 DNA damage-induced activation of ATM promotes -TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012 Sep;3(9):1026-35.
REF 54 Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 9;18(2):147-59.
REF 55 HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations. FEBS Lett. 2005 Oct 24;579(25):5473-80.
REF 56 MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell. 2007 Mar 9;25(5):739-50.
REF 57 Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7. EMBO Rep. 2018 Feb;19(2):305-319.
REF 58 p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). J Biol Chem. 2013 Feb 1;288(5):3359-69.
REF 59 The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. EMBO J. 2011 Feb 2;30(3):468-79.
REF 60 Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 2002 Aug 1;21(15):4037-48.
REF 61 Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents. Cancer Res. 2007 Jun 1;67(11):5513-21.
REF 62 MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells. Biochem Biophys Res Commun. 2001 Feb 16;281(1):259-65.
REF 63 An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability. FEBS Lett. 2012 Apr 24;586(8):1135-40.
REF 64 Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition. Biochem Biophys Res Commun. 2012 Jan 13;417(2):744-6.
REF 65 USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Cell Rep. 2016 Mar 22;14(11):2528-37.
REF 66 Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct Mol Biol. 2006 Mar;13(3):285-91.
REF 67 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol. 2006 Feb;4(2):e27.
REF 68 Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7. J Mol Biol. 2010 Oct 8;402(5):825-37.
REF 69 A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells. Oncogene. 1998 Nov 19;17(20):2629-36.
REF 70 MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell. 2005 Dec 9;20(5):699-708.
REF 71 NUMB controls p53 tumour suppressor activity. Nature. 2008 Jan 3;451(7174):76-80.
REF 72 Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science. 2003 Dec 12;302(5652):1972-5.
REF 73 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science. 1996 Nov 8;274(5289):948-53.
REF 74 Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells. Nat Methods. 2005 Jun;2(6):427-33.
REF 75 The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem. 2009 May 8;284(19):12622-32.
REF 76 Roles for negative cell regulator 14-3-3sigma in control of MDM2 activities. Oncogene. 2007 Nov 15;26(52):7355-62.
REF 77 Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol. 2006 Sep;26(18):6819-31.
REF 78 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol. 2010 Mar;30(6):1508-27.
REF 79 MDMX regulation of p53 response to ribosomal stress. EMBO J. 2006 Nov 29;25(23):5614-25.
REF 80 PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop. Nucleic Acids Res. 2011 Mar;39(6):2234-48.
REF 81 5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem. 2007 Mar 16;282(11):8052-9.
REF 82 Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation. J Biol Chem. 2011 Nov 4;286(44):38264-74.
REF 83 Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem. 2004 Oct 22;279(43):44475-82.
REF 84 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 85 Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26. Nucleic Acids Res. 2010 Oct;38(19):6544-54.
REF 86 Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell. 2008 Oct 24;32(2):180-9.
REF 87 Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20467-72.
REF 88 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004 Sep;24(17):7654-68.
REF 89 The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol Cell Biol. 1994 Nov;14(11):7414-20.
REF 90 Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007 Aug 2;26(35):5029-37.
REF 91 Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS One. 2013 Jul 16;8(7):e68667.
REF 92 Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. Cell Host Microbe. 2014 Apr 9;15(4):494-505.
REF 93 DNA-binding regulates site-specific ubiquitination of IRF-1. Biochem J. 2013 Feb 1;449(3):707-17.
REF 94 Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1 stabilization/nuclear translocation in bone metastasis from breast carcinoma. Exp Cell Res. 2015 Jan 15;330(2):287-99.
REF 95 Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 2000 Jan 1;14(1):34-44.
REF 96 Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem. 2003 Apr 18;278(16):13595-8.
REF 97 TIP60 represses transcriptional activity of p73beta via an MDM2-bridged ternary complex. J Biol Chem. 2008 Jul 18;283(29):20077-86.
REF 98 MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function. Oncotarget. 2015 Aug 28;6(25):21479-92.
REF 99 MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol. 1999 May;19(5):3257-66.
REF 100 A novel mechanism of crosstalk between the p53 and NFB pathways: MDM2 binds and inhibits p65RelA. Cell Cycle. 2013 Aug 1;12(15):2479-92.
REF 101 Coordinate regulation of estrogen receptor degradation by Mdm2 and CREB-binding protein in response to growth signals. Oncogene. 2013 Jan 3;32(1):117-26.
REF 102 Inhibition of p53 degradation by Mdm2 acetylation. FEBS Lett. 2004 Mar 12;561(1-3):195-201.
REF 103 Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. BMC Biol. 2011 Nov 30;9:83.
REF 104 Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway. Biochem J. 2013 Mar 15;450(3):523-36.
REF 105 Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene. 2005 Nov 3;24(48):7238-47.
REF 106 ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1. FEBS J. 2008 Oct;275(19):4875-86.
REF 107 Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. Mol Cell. 2016 Jun 16;62(6):890-902.
REF 108 MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem. 2010 Aug 27;285(35):26908-15.
REF 109 Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase. Antioxid Redox Signal. 2011 Feb 15;14(4):563-78.
REF 110 A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity. PLoS One. 2015 Dec 11;10(12):e0144753.
REF 111 Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2. Biochem J. 2009 Mar 15;418(3):575-85.
REF 112 MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation. J Cell Sci. 2010 Jul 15;123(Pt 14):2423-33.
REF 113 Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73. Cell Cycle. 2010 Nov 15;9(22):4584-91.
REF 114 MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem. 2009 May 22;284(21):13987-4000.
REF 115 Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. J Biol Chem. 2011 Jul 1;286(26):22730-41.
REF 116 Regulation of p53 level by UBE4B in breast cancer. PLoS One. 2014 Feb 26;9(2):e90154.
REF 117 UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53. Nat Med. 2011 Mar;17(3):347-55.
REF 118 OTUD5 regulates p53 stability by deubiquitinating p53. PLoS One. 2013 Oct 15;8(10):e77682.
REF 119 The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell. 2005 Jul;8(1):75-87.
REF 120 MDMX contains an autoinhibitory sequence element. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17814-9.
REF 121 Reciprocal repression between P53 and TCTP. Nat Med. 2011 Dec 11;18(1):91-9.
REF 122 Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell. 2009 Aug 14;35(3):316-26.
REF 123 Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ. 2008 May;15(5):841-8.
REF 124 Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy. Cancer Res. 2015 Nov 1;75(21):4560-72.
REF 125 HDMX folds the nascent p53 mRNA following activation by the ATM kinase. Mol Cell. 2014 May 8;54(3):500-11.
REF 126 Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem. 2003 Feb 21;278(8):6363-70.
REF 127 Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science. 2001 Nov 9;294(5545):1307-13.
REF 128 Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of -arrestin2. Mol Biol Cell. 2011 May;22(9):1608-16.
REF 129 MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem. 2004 Apr 16;279(16):16000-6.
REF 130 MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change. J Biol Chem. 2010 Jun 11;285(24):18407-14.
REF 131 Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem Biophys Res Commun. 2003 Mar 21;302(4):869-72.
REF 132 MDM2 interacts with and downregulates a sarcomeric protein, TCAP. Biochem Biophys Res Commun. 2006 Jun 23;345(1):355-61.
REF 133 Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization. Oncogene. 2006 Nov 23;25(55):7274-88.
REF 134 A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J Biol Chem. 2000 Oct 13;275(41):31883-90.
REF 135 An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis. J Proteome Res. 2012 Nov 2;11(11):5464-78.
REF 136 Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell. 2004 May;5(5):465-75.
REF 137 Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem. 2003 Mar 28;278(13):11648-53.
REF 138 MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol Cell Biol. 2006 Oct;26(19):7269-82.
REF 139 The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity. Biochem Biophys Res Commun. 2007 Nov 23;363(3):879-84.
REF 140 Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. J Biol Chem. 2005 May 13;280(19):18771-81.
REF 141 BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. Oncogene. 2013 Jun 27;32(26):3156-64.
REF 142 Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J Cell Sci. 2003 Oct 1;116(Pt 19):3917-25.
REF 143 p14ARF interacts with DAXX: effects on HDM2 and p53. Cell Cycle. 2008 Jun 15;7(12):1836-50.
REF 144 Negative regulation of p53 functions by Daxx and the involvement of MDM2. J Biol Chem. 2004 Nov 26;279(48):50566-79.
REF 145 MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Mol Cell. 2016 Jan 7;61(1):68-83.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.