Target General Information
Target ID T02677 Target Info
Target Name Apoptosis inhibitor survivin (BIRC5)
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; API4
Target Type Clinical trial Target
Gene Name BIRC5
Biochemical Class Acyltransferase
UniProt ID
BIRC5_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [2]
Kinases [+] 1 Kinases +
Interacting Target Name Aurora kinase B (AURKB) Clinical trial Target Interacting Protein Info
UniProt ID
AURKB_HUMAN 
Synonyms STK5; STK12; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora/IPL1-related kinase 2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK-2; ARK2; AIRK2; AIM-1; AIM1; AIK2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-localization [5]
3 Reconstituted Complex [6]
4 Yeast two hybrid [7]
Peptidases [+] 3 Peptidases +
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [8]
2 Reconstituted Complex [9]
Interacting Target Name Caspase-9 (CASP9) Clinical trial Target Interacting Protein Info
UniProt ID
CASP9_HUMAN 
Synonyms MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-localization [11]
Interacting Target Name Caspase-7 (CASP7) Clinical trial Target Interacting Protein Info
UniProt ID
CASP7_HUMAN 
Synonyms MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [8]
2 Reconstituted Complex [9]
Other proteins [+] 3 Other proteins +
Interacting Target Name Borealin (CDCA8) Literature-reported Target Interacting Protein Info
UniProt ID
BOREA_HUMAN 
Synonyms Pluripotent embryonic stem cell-related gene 3 protein; Pluripotent embryonic stem cellrelated gene 3 protein; PESCRG3; hDasra-B; hDasraB; Dasra-B; DasraB; Dasra B; Cell division cycle-associated protein 8; Cell division cycleassociated protein 8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [4]
4 Yeast two hybrid [13]
Interacting Protein Name Inner centromere protein (INCENP) Interacting Protein Interacting Protein Info
UniProt ID
INCE_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [4]
3 Co-localization [7]
4 Reconstituted Complex [7]
Interacting Target Name Direct IAP-binding protein with low pI (DIABLO) Literature-reported Target Interacting Protein Info
UniProt ID
DBLOH_HUMAN 
Synonyms Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Fluorescence Resonance Energy Transfer [15]
3 Reconstituted Complex [15]
References
REF 1 Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. J Biol Chem. 2007 Sep 7;282(36):26202-9.
REF 2 An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13;279(33):34087-90.
REF 3 Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells. J Biol Chem. 2015 Apr 17;290(16):9974-85.
REF 4 The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 2006 Dec;7(12):1259-65.
REF 5 INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009 Nov 30;187(5):637-53.
REF 6 Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. J Biol Chem. 2003 Jan 3;278(1):486-90.
REF 7 INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol. 2001 Jun 5;11(11):886-90.
REF 8 An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. 2001 Jan 30;40(4):1117-23.
REF 9 IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20.
REF 10 Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13103-7.
REF 11 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 12 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 13 Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007 Oct 19;131(2):271-85.
REF 14 Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. J Biol Chem. 2003 Jun 20;278(25):23130-40.
REF 15 Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem. 2011 Jul 1;286(26):23296-307.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.