Target General Information
Target ID T03634 Target Info
Target Name CREB-binding protein (CREBBP)
Synonyms CREBbinding protein; CBP
Target Type Clinical trial Target
Gene Name CREBBP
Biochemical Class Acyltransferase
UniProt ID
CBP_HUMAN 
Target Interacting Proteins
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name X-ray repair cross-complementing protein 6 (XRCC6) Interacting Protein Interacting Protein Info
UniProt ID
XRCC6_HUMAN 
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [1]
3 Reconstituted Complex [2]
4 Yeast two hybrid [2]
Acyltransferases [+] 6 Acyltransferases +
Interacting Target Name Histone acetyltransferase KAT2B (KAT2B) Literature-reported Target Interacting Protein Info
UniProt ID
KAT2B_HUMAN 
Synonyms Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Co-fractionation [3]
4 Reconstituted Complex [5]
5 Reconstituted Complex [4]
6 Reconstituted Complex [6]
7 Yeast two hybrid [6]
Interacting Protein Name Cyclic AMP-dependent transcription factor ATF-2 (ATF2) Interacting Protein Interacting Protein Info
UniProt ID
ATF2_HUMAN 
Synonyms CRE.BP1; CREB.2; CREB2; HB16; TREB7
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Reconstituted Complex [11]
6 Reconstituted Complex [8]
7 Yeast two hybrid [8]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [14]
4 Reconstituted Complex [12]
5 Reconstituted Complex [15]
6 Reconstituted Complex [16]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [17]
3 Reconstituted Complex [18]
4 Reconstituted Complex [19]
5 Reconstituted Complex [20]
6 Yeast two hybrid [19]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [22]
4 Reconstituted Complex [17]
5 Yeast two hybrid [17]
Interacting Protein Name SUMO-conjugating enzyme UBC9 (UBE2I) Interacting Protein Interacting Protein Info
UniProt ID
UBC9_HUMAN 
Synonyms C358B7.1; P18; UBC9
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [23]
2 Reconstituted Complex [24]
3 Yeast two hybrid [25]
Glycosylases [+] 1 Glycosylases +
Interacting Target Name Thymine-DNA glycosylase (TDG) Literature-reported Target Interacting Protein Info
UniProt ID
TDG_HUMAN 
Synonyms Thymine-DNA glycosylase; hTDG
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [26]
3 Biochemical Activity [5]
4 Co-fractionation [5]
5 Reconstituted Complex [5]
6 Reconstituted Complex [27]
7 Yeast two hybrid [5]
Kinases [+] 5 Kinases +
Interacting Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target Interacting Protein Info
UniProt ID
FGFR1_HUMAN 
Synonyms N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Affinity Capture-Western [29]
3 Co-localization [29]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Co-localization [30]
3 Reconstituted Complex [31]
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [32]
2 Far Western [33]
3 Reconstituted Complex [33]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [35]
3 Yeast two hybrid [34]
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target Interacting Protein Info
UniProt ID
IKKB_HUMAN 
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitory kappa B kinase b; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-beta; IKKbeta; IKK-B; IKK-2; IKK2; IkBKB; I-kappa-B-kinase beta; IkappaB kinase beta; I-kappa-B kinase 2; IkappaB kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Co-localization [36]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Importin subunit alpha-1 (KPNA2) Interacting Protein Interacting Protein Info
UniProt ID
IMA1_HUMAN 
Synonyms IPOA1; QIP2; RCH1; SRP1alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Biochemical Activity [38]
Nuclear hormone receptors [+] 5 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [40]
4 Yeast two hybrid [39]
5 Yeast two hybrid [41]
Interacting Target Name Hepatocyte nuclear factor 4-alpha (HNF4A) Literature-reported Target Interacting Protein Info
UniProt ID
HNF4A_HUMAN 
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF-14; TCF14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF-4-alpha; HNF4
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Biochemical Activity [43]
3 Reconstituted Complex [44]
4 Reconstituted Complex [45]
5 Yeast two hybrid [44]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-peptide [46]
2 Reconstituted Complex [47]
3 Yeast two hybrid [48]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Reconstituted Complex [50]
3 Yeast two hybrid [51]
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Reconstituted Complex [53]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Target Name Mixed-lineage leukemia protein (MLL) Literature-reported Target Interacting Protein Info
UniProt ID
KMT2A_HUMAN 
Synonyms Zinc finger protein HRX; Trithorax-like protein; Trithoraxlike protein; p320; p180; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Myeloid/lymphoid or mixed-lineage leukemia; MLL1; MLL cleavage product C180; Lysine N-methyltransferase 2A; Lysine Nmethyltransferase 2A; HTRX; HRX; Histonelysine Nmethyltransferase MLL; Histone-lysine N-methyltransferase 2A; CXXC-type zinc finger protein 7; CXXCtype zinc finger protein 7; CXXC7; ALL-1; ALL1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Co-crystal Structure [55]
3 Co-crystal Structure [56]
4 Reconstituted Complex [55]
5 Reconstituted Complex [54]
6 Reconstituted Complex [57]
7 Yeast two hybrid [54]
Interacting Target Name Histone-arginine methyltransferase CARM1 (CARM1) Literature-reported Target Interacting Protein Info
UniProt ID
CARM1_HUMAN 
Synonyms Protein arginine N-methyltransferase 4; PRMT4; Histonearginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Coactivatorassociated arginine methyltransferase 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [58]
2 Biochemical Activity [59]
3 Reconstituted Complex [58]
4 Yeast two hybrid [58]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [60]
2 Affinity Capture-Western [35]
3 Affinity Capture-Western [61]
4 Affinity Capture-Western [62]
5 Biochemical Activity [63]
6 Biochemical Activity [64]
7 Biochemical Activity [24]
8 Biochemical Activity [65]
9 Biochemical Activity [66]
10 Biochemical Activity [67]
11 Biochemical Activity [68]
12 Biochemical Activity [69]
13 Co-crystal Structure [70]
14 Protein-peptide [71]
15 Reconstituted Complex [72]
16 Reconstituted Complex [73]
17 Reconstituted Complex [60]
18 Reconstituted Complex [18]
19 Reconstituted Complex [68]
20 Reconstituted Complex [74]
Transcription regulators [+] 33 Transcription regulators +
Interacting Target Name Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Interacting Protein Info
UniProt ID
CREB1_HUMAN 
Synonyms Cyclic AMP-responsive element-binding protein 1; Cyclic AMP responseelement-binding protein; CREB-1; CREB; cAMP-responsive element-binding protein 1; CAMP-response element binding protein
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [75]
2 Affinity Capture-Western [76]
3 Affinity Capture-Western [10]
4 Affinity Capture-Western [77]
5 Affinity Capture-Western [78]
6 Affinity Capture-Western [79]
7 Affinity Capture-Western [80]
8 Affinity Capture-Western [81]
9 Co-crystal Structure [56]
10 Co-crystal Structure [82]
11 Far Western [83]
12 Far Western [84]
13 Reconstituted Complex [83]
14 Reconstituted Complex [8]
15 Reconstituted Complex [73]
16 Reconstituted Complex [75]
17 Reconstituted Complex [78]
18 Reconstituted Complex [82]
19 Reconstituted Complex [85]
20 Reconstituted Complex [86]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-Western [87]
2 Affinity Capture-Western [34]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [88]
6 Affinity Capture-Western [89]
7 Affinity Capture-Western [90]
8 Affinity Capture-Western [91]
9 Affinity Capture-Western [92]
10 Affinity Capture-Western [93]
11 Affinity Capture-Western [94]
12 Reconstituted Complex [95]
13 Reconstituted Complex [11]
14 Reconstituted Complex [20]
15 Reconstituted Complex [91]
16 Reconstituted Complex [96]
17 Yeast two hybrid [91]
18 Yeast two hybrid [34]
Interacting Target Name Interferon regulatory factor 3 (IRF3) Literature-reported Target Interacting Protein Info
UniProt ID
IRF3_HUMAN 
Synonyms IRF-3
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-Western [97]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [98]
4 Affinity Capture-Western [99]
5 Affinity Capture-Western [88]
6 Affinity Capture-Western [100]
7 Affinity Capture-Western [101]
8 Affinity Capture-Western [102]
9 Affinity Capture-Western [103]
10 Affinity Capture-Western [104]
11 Affinity Capture-Western [105]
12 Affinity Capture-Western [106]
13 Affinity Capture-Western [107]
14 Reconstituted Complex [108]
Interacting Protein Name Transcriptional activator Myb (MYB) Interacting Protein Interacting Protein Info
UniProt ID
MYB_HUMAN 
Synonyms Transcriptional activator Myb; Proto-oncogene c-Myb
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [109]
2 Biochemical Activity [110]
3 Co-crystal Structure [111]
4 Co-crystal Structure [56]
5 Reconstituted Complex [111]
6 Reconstituted Complex [109]
7 Reconstituted Complex [110]
8 Reconstituted Complex [112]
9 Reconstituted Complex [113]
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [114]
2 Affinity Capture-Western [94]
3 Affinity Capture-Western [115]
4 Affinity Capture-Western [116]
5 Biochemical Activity [116]
6 Reconstituted Complex [117]
7 Reconstituted Complex [118]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [119]
2 Affinity Capture-Western [120]
3 Affinity Capture-Western [60]
4 Affinity Capture-Western [30]
5 Reconstituted Complex [121]
6 Reconstituted Complex [60]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [122]
2 Affinity Capture-Western [123]
3 Affinity Capture-Western [124]
4 Affinity Capture-Western [125]
5 Yeast two hybrid [126]
Interacting Target Name Nuclear factor erythroid 2-related factor 2 (Nrf2) Clinical trial Target Interacting Protein Info
UniProt ID
NF2L2_HUMAN 
Synonyms Nuclear factor, erythroid derived 2, like 2; NRF2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [89]
2 Affinity Capture-Western [127]
3 Biochemical Activity [127]
4 Reconstituted Complex [128]
5 Yeast two hybrid [128]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [129]
3 Far Western [84]
4 Reconstituted Complex [11]
5 Reconstituted Complex [8]
Interacting Target Name Kruppel like factor 4 (KLF4) Clinical trial Target Interacting Protein Info
UniProt ID
KLF4_HUMAN 
Synonyms Krueppel-like factor 4; Krueppellike factor 4; Gut-enriched krueppel-like factor; Gutenriched krueppellike factor; GKLF; EZF; Epithelial zinc finger protein EZF
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [130]
2 Biochemical Activity [131]
3 Co-localization [132]
4 Reconstituted Complex [130]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [133]
2 Biochemical Activity [134]
3 Reconstituted Complex [134]
4 Yeast two hybrid [134]
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [135]
2 Affinity Capture-Western [136]
3 Biochemical Activity [135]
4 Reconstituted Complex [137]
Interacting Target Name Transcription factor E2-alpha (TCF3) Literature-reported Target Interacting Protein Info
UniProt ID
TFE2_HUMAN 
Synonyms Transcription factor ITF-1; Transcription factor 3; TCF-3; Kappa-E2-binding factor; ITF1; Immunoglobulin transcription factor 1; Immunoglobulin enhancer-binding factor E12/E47; E2A; Class B basic helix-loop-helix protein 21; bHLHb21
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [138]
2 Biochemical Activity [139]
3 Protein-peptide [139]
4 Reconstituted Complex [140]
Interacting Protein Name Homeobox protein Hox-B6 (HOXB6) Interacting Protein Interacting Protein Info
UniProt ID
HXB6_HUMAN 
Synonyms HOX2; HOX2B; HU.2; Hox.2.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [141]
2 Affinity Capture-Western [142]
3 Reconstituted Complex [141]
4 Reconstituted Complex [142]
Interacting Protein Name Myoblast determination protein 1 (MYOD1) Interacting Protein Interacting Protein Info
UniProt ID
MYOD1_HUMAN 
Synonyms MYF3; MYOD; PUM; bHLHc1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [143]
2 Biochemical Activity [144]
3 Biochemical Activity [64]
4 Reconstituted Complex [143]
Interacting Protein Name Autoimmune regulator (AIRE) Interacting Protein Interacting Protein Info
UniProt ID
AIRE_HUMAN 
Synonyms AIRE1; APECED; APS1; APSI; PGA1
Evidence Score (E-score) 4 Experimental Evidences +
1 Far Western [145]
2 Far Western [146]
3 Yeast two hybrid [145]
4 Yeast two hybrid [146]
Interacting Protein Name Homeobox protein Hox-B7 (HOXB7) Interacting Protein Interacting Protein Info
UniProt ID
HXB7_HUMAN 
Synonyms HHO.C1; HOX2; HOX2C; Hox.2.3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [142]
2 Reconstituted Complex [147]
3 Reconstituted Complex [142]
4 Yeast two hybrid [147]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [148]
2 Reconstituted Complex [149]
3 Reconstituted Complex [150]
4 Yeast two hybrid [149]
Interacting Protein Name Signal transducer and activator of transcription 2 (STAT2) Interacting Protein Interacting Protein Info
UniProt ID
STAT2_HUMAN 
Synonyms ISGF.3; P113; STAT113
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [151]
2 Reconstituted Complex [151]
3 Reconstituted Complex [152]
4 Yeast two hybrid [151]
Interacting Target Name Sterol regulatory element binding protein-1 (SREBF1) Literature-reported Target Interacting Protein Info
UniProt ID
SRBP1_HUMAN 
Synonyms Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding protein 1; SREBP-1; SREBP1; SREBP 1; Class D basic helix-loop-helix protein 1; bHLHd1
Evidence Score (E-score) 3 Experimental Evidences +
1 Far Western [153]
2 Reconstituted Complex [154]
3 Reconstituted Complex [56]
Interacting Protein Name Serum response factor (SRF) Interacting Protein Interacting Protein Info
UniProt ID
SRF_HUMAN 
Synonyms MCM1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [155]
2 Affinity Capture-Western [156]
3 Yeast two hybrid [156]
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [157]
2 Biochemical Activity [158]
Interacting Target Name Hepatocyte nuclear factor 1-alpha (HNF1A) Clinical trial Target Interacting Protein Info
UniProt ID
HNF1A_HUMAN 
Synonyms Transcription factor-1; Transcription factor 1; TCF-1; TCF1; Liver-specific transcription factor LF-B1; Liver specific transcription factor LF-B1; LFB1; HNF-1-alpha; HNF-1A; HNF-1 alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [159]
2 Reconstituted Complex [160]
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [161]
2 Yeast two hybrid [162]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [163]
2 Affinity Capture-Western [164]
Interacting Target Name Activating transcription factor 4 (ATF-4) Literature-reported Target Interacting Protein Info
UniProt ID
ATF4_HUMAN 
Synonyms TXREB; Tax-responsive enhancer element-binding protein 67; Taxresponsive enhancer elementbinding protein 67; TaxREB67; DNA-binding protein TAXREB67; DNAbinding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Cyclic AMPresponsive elementbinding protein 2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMPdependent transcription factor ATF4; CREB-2; CREB2; cAMP-responsive element-binding protein 2; cAMPresponsive elementbinding protein 2; cAMP-dependent transcription factor ATF-4; cAMPdependent transcription factor ATF4
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [36]
2 Reconstituted Complex [165]
Interacting Target Name Protein C-ets-1 (ETS1) Literature-reported Target Interacting Protein Info
UniProt ID
ETS1_HUMAN 
Synonyms P54; EWSR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [129]
2 Reconstituted Complex [166]
Interacting Target Name Proto-oncogene c-Fos (c-Fos) Literature-reported Target Interacting Protein Info
UniProt ID
FOS_HUMAN 
Synonyms Proto-oncogene c-Fos; G0S7; G0/G1 switch regulatory protein 7; C-fos; Cellular oncogene fos
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [167]
2 Reconstituted Complex [40]
Interacting Target Name High mobility group protein HMG-I/Y (HMGA1) Literature-reported Target Interacting Protein Info
UniProt ID
HMGA1_HUMAN 
Synonyms HMGIY; HMG-I(Y); High mobility group protein R; High mobility group protein HMG-I/HMG-Y; High mobility group protein A1; High mobility group AT-hook protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [168]
2 Yeast two hybrid [169]
Interacting Protein Name Forkhead box protein O4 (FOXO4) Interacting Protein Interacting Protein Info
UniProt ID
FOXO4_HUMAN 
Synonyms AFX; AFX1; MLLT7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [170]
2 Reconstituted Complex [137]
Interacting Protein Name Hepatocyte nuclear factor 6 (ONECUT1) Interacting Protein Interacting Protein Info
UniProt ID
HNF6_HUMAN 
Synonyms HNF.6; HNF6; HNF6A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [171]
2 Reconstituted Complex [172]
Interacting Protein Name Myb-related protein A (MYBL1) Interacting Protein Interacting Protein Info
UniProt ID
MYBA_HUMAN 
Synonyms A.MYB; AMYB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [109]
2 Reconstituted Complex [173]
Interacting Protein Name Sterol regulatory element-binding protein 2 (SREBF2) Interacting Protein Interacting Protein Info
UniProt ID
SRBP2_HUMAN 
Synonyms SREBP.2; SREBP2; bHLHd2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [174]
2 Far Western [153]
Ubiquitin related proteins [+] 3 Ubiquitin related proteins +
Interacting Protein Name Anaphase-promoting complex subunit 7 (ANAPC7) Interacting Protein Interacting Protein Info
UniProt ID
APC7_HUMAN 
Synonyms APC7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [175]
2 Affinity Capture-Western [176]
3 Reconstituted Complex [175]
Interacting Protein Name Small ubiquitin-related modifier 1 (SUMO1) Interacting Protein Interacting Protein Info
UniProt ID
SUMO1_HUMAN 
Synonyms DAP1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; UBL1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [177]
2 Reconstituted Complex [177]
3 Reconstituted Complex [24]
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [178]
2 Biochemical Activity [179]
Other proteins [+] 4 Other proteins +
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [180]
2 Affinity Capture-Western [181]
3 Affinity Capture-Western [182]
4 Biochemical Activity [183]
5 Reconstituted Complex [180]
6 Yeast two hybrid [180]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [155]
2 Affinity Capture-Western [184]
3 Affinity Capture-Western [185]
4 Reconstituted Complex [184]
Interacting Target Name Huntingtin (HTT) Literature-reported Target Interacting Protein Info
UniProt ID
HD_HUMAN 
Synonyms IT15; Huntington disease protein; Huntingtin; HD protein; HD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [186]
2 Co-fractionation [187]
3 Reconstituted Complex [188]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [189]
2 Co-localization [190]
References
REF 1 Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell. 2004 Mar 12;13(5):627-38.
REF 2 Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex. Mol Cell Biol. 1998 Mar;18(3):1349-58.
REF 3 A human RNA polymerase II complex containing factors that modify chromatin structure. Mol Cell Biol. 1998 Sep;18(9):5355-63.
REF 4 A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996 Jul 25;382(6589):319-24.
REF 5 Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell. 2002 Feb;9(2):265-77.
REF 6 Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science. 1998 Jan 30;279(5351):703-7.
REF 7 A novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters I.3 and II by disrupting a transcriptional complex in br... J Biol Chem. 2006 Feb 3;281(5):2585-97.
REF 8 CBP alleviates the intramolecular inhibition of ATF-2 function. J Biol Chem. 1998 Oct 30;273(44):29098-105.
REF 9 Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis. J Biol Chem. 2007 May 18;282(20):15022-32.
REF 10 Prostaglandin E2 signalling pathway in human T lymphocytes from healthy and conjunctiva basal cell carcinoma-bearing subjects. Immunol Cell Biol. 2001 Oct;79(5):482-9.
REF 11 Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol Cell. 1998 Jan;1(2):277-87.
REF 12 CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1020-5.
REF 13 BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells. Exp Cell Res. 2006 Oct 1;312(16):3120-31.
REF 14 New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. Breast Cancer Res. 2006;8(1):R1.
REF 15 Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res. 1998 Feb 1;26(3):847-53.
REF 16 The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene. 1999 Jan 7;18(1):263-8.
REF 17 The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 1997 Jun 12;387(6634):677-84.
REF 18 A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP. J Biol Chem. 2004 Apr 2;279(14):14055-64.
REF 19 Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1. Mol Cell Biol. 2001 Jan;21(1):39-50.
REF 20 Down regulation of the interleukin-8 promoter by human papillomavirus type 16 E6 and E7 through effects on CREB binding protein/p300 and P/CAF. J Virol. 2002 Sep;76(17):8710-21.
REF 21 Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004 Sep 24;15(6):937-49.
REF 22 A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996 May 3;85(3):403-14.
REF 23 Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response. EMBO J. 2013 Mar 20;32(6):791-804.
REF 24 Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5335-E5342.
REF 25 A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions. Int J Biochem Cell Biol. 2012 Mar;44(3):547-55.
REF 26 Thymine DNA glycosylase promotes transactivation of -catenin/TCFs by cooperating with CBP. J Mol Cell Biol. 2014 Jun;6(3):231-9.
REF 27 SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment. Mol Cell Biol. 2007 Jan;27(1):229-43.
REF 28 Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation. J Biol Chem. 2005 Aug 5;280(31):28451-62.
REF 29 A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during developmental gene programming of embryonic stem cells. J Cell Biochem. 2012 Sep;113(9):2920-36.
REF 30 Role of CBP in regulating HIF-1-mediated activation of transcription. J Cell Sci. 2005 Jan 15;118(Pt 2):301-11.
REF 31 Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1. Biochem J. 2012 Mar 15;442(3):611-20.
REF 32 Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005 Oct;19(10):2451-65.
REF 33 Casein kinase II interacts with the bZIP domains of several transcription factors. Nucleic Acids Res. 1998 Aug 15;26(16):3854-61.
REF 34 Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression. J Biol Chem. 2004 Jan 30;279(5):3509-15.
REF 35 Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell. 2007 Apr 13;26(1):75-87.
REF 36 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 37 Functional interaction of CREB binding protein (CBP) with nuclear transport proteins and modulation by HDAC inhibitors. Cell Cycle. 2006 Sep;5(18):2146-52.
REF 38 Acetylation of importin-alpha nuclear import factors by CBP/p300. Curr Biol. 2000 Apr 20;10(8):467-70.
REF 39 Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment. J Mol Endocrinol. 2004 Feb;32(1):307-23.
REF 40 p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res. 2002 Jan 1;62(1):141-51.
REF 41 A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. 1997 Jun 12;387(6634):733-6.
REF 42 Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4. J Biol Chem. 1998 Nov 6;273(45):29950-7.
REF 43 Acetylation regulates transcription factor activity at multiple levels. Mol Cell. 2000 Apr;5(4):745-51.
REF 44 Functional association between CBP and HNF4 in trans-activation. Biochem Biophys Res Commun. 1997 Dec 29;241(3):664-9.
REF 45 CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression. J Biol Chem. 1999 Mar 26;274(13):9013-21.
REF 46 Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics. 2009 Oct;8(10):2212-26.
REF 47 Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol. 2000 Jul;20(13):4699-707.
REF 48 A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. Anal Biochem. 2004 Dec 15;335(2):253-9.
REF 49 Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell. 2010 Jun 15;17(6):535-46.
REF 50 CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1. J Biol Chem. 1998 Nov 27;273(48):31853-9.
REF 51 The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus. J Mol Endocrinol. 2005 Feb;34(1):107-18.
REF 52 Recruitment of cAMP-response element-binding protein and histone deacetylase has opposite effects on glucocorticoid receptor gene transcription. J Biol Chem. 2010 Feb 12;285(7):4489-510.
REF 53 Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors. Biochemistry. 1998 Jun 30;37(26):9586-94.
REF 54 MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol. 2001 Apr;21(7):2249-58.
REF 55 Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation do... J Biol Chem. 2002 Nov 8;277(45):43168-74.
REF 56 An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10;442(7103):700-4.
REF 57 Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300. J Mol Biol. 2007 Sep 28;372(4):958-69.
REF 58 A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21;294(5551):2507-11.
REF 59 The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007 Jan;27(1):120-34.
REF 60 Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300. J Biol Chem. 2010 Jan 22;285(4):2601-9.
REF 61 Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol Cell Biol. 2006 Apr;26(7):2782-90.
REF 62 A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. Neoplasia. 2013 Aug;15(8):952-65.
REF 63 Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 2011 Mar 10;471(7337):189-95.
REF 64 Tat-controlled protein acetylation. J Biol Chem. 2002 Oct 4;277(40):37955-60.
REF 65 MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J. 2002 Nov 15;21(22):6236-45.
REF 66 Acetylation is indispensable for p53 activation. Cell. 2008 May 16;133(4):612-26.
REF 67 CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16275-80.
REF 68 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell. 2004 Jan 30;13(2):251-63.
REF 69 Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci. 2008 Aug 27;28(35):8772-84.
REF 70 The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb. J Mol Biol. 2014 Dec 12;426(24):4030-4048.
REF 71 Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19290-5.
REF 72 CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res. 1997 Sep 1;57(17):3693-6.
REF 73 p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation. Mol Cell Biol. 2000 Jul;20(13):4849-58.
REF 74 p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300. J Biol Chem. 2002 Mar 15;277(11):9054-61.
REF 75 Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5898-903.
REF 76 Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor. Endocrinology. 2003 Sep;144(9):3934-42.
REF 77 Temporal recruitment of transcription factors at the 3',5'-cyclic adenosine 5'-monophosphate-response element of the human GnRH-II promoter. Endocrinology. 2008 Oct;149(10):5162-71.
REF 78 Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17622-7.
REF 79 Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation. J Mol Cell Cardiol. 2010 Aug;49(2):176-85.
REF 80 Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. J Immunol. 2001 May 1;166(9):5665-74.
REF 81 Tumor necrosis factor -induced hypoxia-inducible factor 1--catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling. Mol Cell Biol. 2013 Jul;33(14):2718-31.
REF 82 Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 1997 Dec 12;91(6):741-52.
REF 83 Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature. 1995 Mar 2;374(6517):85-8.
REF 84 Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 1994 Jul 21;370(6486):226-9.
REF 85 Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response eleme... J Biol Chem. 1996 Jul 26;271(30):17957-60.
REF 86 Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Mol Cell Biol. 2000 Jul;20(14):4970-8.
REF 87 PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit. J Biol Chem. 2004 Jun 4;279(23):24873-80.
REF 88 Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. Blood. 2007 Apr 1;109(7):2887-93.
REF 89 NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta. 2008 May;1783(5):713-27.
REF 90 The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell. 2002 Mar;9(3):625-36.
REF 91 CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2927-32.
REF 92 High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-kappaB-CBP ternary complex in the cytoplasm. Oncogene. 2005 Jun 30;24(28):4521-30.
REF 93 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell. 2014 Oct 13;26(4):534-48.
REF 94 Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression. Mol Cell Biol. 2015 May;35(10):1660-72.
REF 95 Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription. J Immunol. 1997 Dec 1;159(11):5450-6.
REF 96 Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Mol Cell Biol. 1999 Sep;19(9):6323-32.
REF 97 Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol. 1998 May;18(5):2986-96.
REF 98 Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol. 2006 Oct 15;177(8):5059-67.
REF 99 Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains. Mol Cell Biol. 1999 Apr;19(4):2465-74.
REF 100 Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J Biol Chem. 2007 Nov 2;282(44):32208-21.
REF 101 Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology. 2007 Apr 10;360(2):305-21.
REF 102 Crystal structure of IRF-3 in complex with CBP. Structure. 2005 Sep;13(9):1269-77.
REF 103 HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene. 2001 Feb 15;20(7):800-11.
REF 104 Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 stimulates the transcriptional activity of cellular IRF-3 and IRF-7. J Biol Chem. 2004 Feb 27;279(9):7643-54.
REF 105 Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol. 2004 Nov;11(11):1060-7.
REF 106 The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3. Nat Immunol. 2010 Aug;11(8):743-50.
REF 107 Herpes simplex virus 1-encoded tegument protein VP16 abrogates the production of beta interferon (IFN) by inhibiting NF-B activation and blocking IFN regulatory factor 3 to recruit its coactivator CBP. J Virol. 2013 Sep;87(17):9788-801.
REF 108 Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions. Eur J Biochem. 2002 Dec;269(24):6142-51.
REF 109 The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol Biol Cell. 2005 Oct;16(10):4705-13.
REF 110 Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation. J Biol Chem. 2001 Feb 2;276(5):3674-82.
REF 111 Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. J Biol Chem. 2002 Nov 1;277(44):42241-8.
REF 112 Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski. J Biol Chem. 2004 Apr 16;279(16):16715-26.
REF 113 Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14942-7.
REF 114 Interferon-gamma-activated STAT-1alpha suppresses MMP-9 gene transcription by sequestration of the coactivators CBP/p300. J Leukoc Biol. 2005 Aug;78(2):515-23.
REF 115 Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. J Immunol. 2009 Dec 1;183(11):6981-8.
REF 116 Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev. 2006 Feb 15;20(4):473-85.
REF 117 Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15092-6.
REF 118 Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1074-9.
REF 119 The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells. Biochem Biophys Res Commun. 2006 May 19;343(4):1002-8.
REF 120 Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation. Mol Pharmacol. 2008 Jul;74(1):236-45.
REF 121 Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 1999 Jan 1;13(1):64-75.
REF 122 Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005 Jul 20;24(14):2543-55.
REF 123 The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein. Oncogene. 2004 Oct 28;23(50):8272-81.
REF 124 Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation. J Biol Chem. 2009 Sep 4;284(36):23912-24.
REF 125 Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell. Oncotarget. 2016 Oct 4;7(40):65553-65567.
REF 126 E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. J Biol Chem. 1999 Oct 1;274(40):28716-23.
REF 127 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol. 2009 May;29(10):2658-72.
REF 128 Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells. 2001 Oct;6(10):857-68.
REF 129 Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun. Mol Cell Biol. 2008 Jul;28(13):4240-50.
REF 130 Transactivation and growth suppression by the gut-enriched Krpel-like factor (Krpel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Nucleic Acids Res. 2000 Mar 1;28(5):1106-13.
REF 131 Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem. 2007 Nov 23;282(47):33994-4002.
REF 132 Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors. Blood. 2011 Jun 9;117(23):6383-91.
REF 133 Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. Oncogene. 2007 Jan 18;26(3):382-94.
REF 134 Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep. 2003 May;4(5):484-90.
REF 135 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7.
REF 136 CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol Cancer Ther. 2014 Mar;13(3):687-98.
REF 137 DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10412-7.
REF 138 Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J Biol Chem. 2003 Jan 24;278(4):2370-6.
REF 139 Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation. Biochim Biophys Acta. 2012 May;1819(5):375-81.
REF 140 E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. J Biol Chem. 2004 Dec 31;279(53):55362-71.
REF 141 HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process. J Biol Chem. 2004 Sep 17;279(38):39895-904.
REF 142 The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol Cell Biol. 2001 Nov;21(21):7509-22.
REF 143 Interaction between acetylated MyoD and the bromodomain of CBP and/or p300. Mol Cell Biol. 2001 Aug;21(16):5312-20.
REF 144 CREB-binding protein/p300 activates MyoD by acetylation. J Biol Chem. 2000 Nov 3;275(44):34359-64.
REF 145 The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J Biol Chem. 2000 Jun 2;275(22):16802-9.
REF 146 P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain. J Bone Miner Res. 2003 Aug;18(8):1419-29.
REF 147 CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein. Oncogene. 1999 Jul 8;18(27):4007-14.
REF 148 MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol. 2005 Feb;25(3):988-1002.
REF 149 The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998 Jan 15;17(2):507-19.
REF 150 EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. Nucleic Acids Res. 2005 Jun 24;33(11):3561-9.
REF 151 Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature. 1996 Sep 26;383(6598):344-7.
REF 152 Native Hydrophobic Binding Interactions at the Transition State for Association between the TAZ1 Domain of CBP and the Disordered TAD-STAT2 Are Not a Requirement. Biochemistry. 2017 Aug 15;56(32):4145-4153.
REF 153 SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev. 1996 Nov 15;10(22):2903-11.
REF 154 CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription. J Biol Chem. 1998 Jul 10;273(28):17865-70.
REF 155 PML-nuclear bodies are involved in cellular serum response. Genes Cells. 2003 Mar;8(3):275-86.
REF 156 The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element. J Biol Chem. 1997 Dec 5;272(49):31016-21.
REF 157 Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell. 2001 Feb 9;104(3):365-76.
REF 158 Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science. 2005 Jan 14;307(5707):269-73.
REF 159 Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes. J Biochem. 2004 Sep;136(3):313-9.
REF 160 Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins. J Biol Chem. 2000 Apr 28;275(17):12515-20.
REF 161 The CBP co-activator stimulates E2F1/DP1 activity. Nucleic Acids Res. 1996 Nov 1;24(21):4139-45.
REF 162 Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. Mol Cell Biol. 2003 Jun;23(11):3707-20.
REF 163 Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. Oncogene. 2012 Nov 22;31(47):4946-59.
REF 164 Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers. Oncotarget. 2014 Oct 15;5(19):9349-61.
REF 165 Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein. J Biol Chem. 1997 Sep 19;272(38):24088-95.
REF 166 A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol. 1998 Apr;18(4):2218-29.
REF 167 Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol Cell Biol. 2005 Aug;25(16):6964-79.
REF 168 Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome. Mol Cell. 1998 Oct;2(4):457-67.
REF 169 Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. J Biol Chem. 1999 Aug 6;274(32):22563-8.
REF 170 FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem. 2004 Jul 9;279(28):28873-9.
REF 171 Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol Cell Biol. 2003 Jan;23(2):437-49.
REF 172 Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF). J Biol Chem. 2000 Jul 21;275(29):22098-103.
REF 173 Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. Biochem J. 1997 Jun 15;324 ( Pt 3):729-36.
REF 174 Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome. Mol Cell Biol. 2015 Jan;35(2):356-69.
REF 175 The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature. 2005 Dec 1;438(7068):690-5.
REF 176 Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. J Biol Chem. 2009 Dec 4;284(49):33939-48.
REF 177 Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO. J Biol Chem. 2016 Jun 10;291(24):12658-72.
REF 178 Coordinate regulation of estrogen receptor degradation by Mdm2 and CREB-binding protein in response to growth signals. Oncogene. 2013 Jan 3;32(1):117-26.
REF 179 Inhibition of p53 degradation by Mdm2 acetylation. FEBS Lett. 2004 Mar 12;561(1-3):195-201.
REF 180 Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol Cancer Res. 2002 Nov;1(1):48-55.
REF 181 Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol. 2007 Oct;9(10):1208-15.
REF 182 Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9.
REF 183 The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity. Oncogene. 2004 May 6;23(21):3781-9.
REF 184 Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2627-32.
REF 185 A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet. 1999 Nov;23(3):287-95.
REF 186 Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci. 2005 Dec;30(4):560-71.
REF 187 Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science. 2001 Mar 23;291(5512):2423-8.
REF 188 Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 2001 Oct 18;413(6857):739-43.
REF 189 p21WAF1/CIP1 selectively controls the transcriptional activity of estrogen receptor alpha. Mol Cell Biol. 2005 Mar;25(6):2419-30.
REF 190 Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 6;538(7623):118-122.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.