Target General Information
Target ID T05661 Target Info
Target Name Lecithin-cholesterol acyltransferase (LCAT)
Synonyms Phospholipidcholesterolacyltransferase; Phospholipid-cholesterol acyltransferase; Phosphatidylcholinesterol acyltransferase; Phosphatidylcholine-sterol acyltransferase
Target Type Clinical trial Target
Gene Name LCAT
Biochemical Class Acyltransferase
UniProt ID
Target Interacting Proteins
Other proteins [+] 1 Other proteins +
Interacting Target Name Apolipoprotein A-I (APOA1) Clinical trial Target Interacting Protein Info
UniProt ID
Synonyms Truncated apolipoprotein AI; Apolipoprotein A-I; Apolipoprotein A1; Apo-AI; ApoA-I; ApoAI
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [1]
2 Biochemical Activity [2]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
REF 1 A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun. 1972 Feb 25;46(4):1493-8.
REF 2 Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry. 2005 Jan 25;44(3):1013-25.
REF 3 Secretion of lecithin:cholesterol acyltransferase by brain neuroglial cell lines. Biochem Biophys Res Commun. 1999 Apr 29;258(1):73-6.
REF 4 Effect of apolipoprotein A-I lipidation on the formation and function of pre-beta and alpha-migrating LpA-I particles. Biochemistry. 1999 Feb 9;38(6):1727-35.

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