Target Interacting Protein Information
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T05661 | Target Info | |||
| Target Name | Lecithin-cholesterol acyltransferase (LCAT) | ||||
| Synonyms | Phospholipidcholesterolacyltransferase; Phospholipid-cholesterol acyltransferase; Phosphatidylcholinesterol acyltransferase; Phosphatidylcholine-sterol acyltransferase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | LCAT | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | |||||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Target Name | Apolipoprotein A-I (APOA1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Truncated apolipoprotein AI; Apolipoprotein A-I; Apolipoprotein A1; Apo-AI; ApoA-I; ApoAI | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [1] | |||
| 2 | Biochemical Activity | [2] | |||
| 3 | Reconstituted Complex | [3] | |||
| 4 | Reconstituted Complex | [4] | |||
| References | |||||
| REF 1 | A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun. 1972 Feb 25;46(4):1493-8. | ||||
| REF 2 | Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry. 2005 Jan 25;44(3):1013-25. | ||||
| REF 3 | Secretion of lecithin:cholesterol acyltransferase by brain neuroglial cell lines. Biochem Biophys Res Commun. 1999 Apr 29;258(1):73-6. | ||||
| REF 4 | Effect of apolipoprotein A-I lipidation on the formation and function of pre-beta and alpha-migrating LpA-I particles. Biochemistry. 1999 Feb 9;38(6):1727-35. | ||||
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