Target Interacting Protein Information
Target General Information | |||||
---|---|---|---|---|---|
Target ID | T12819 | Target Info | |||
Target Name | E3 ubiquitin-protein ligase COP1 (RFWD2) | ||||
Synonyms | hCOP1; RNF200; RING-type E3 ubiquitin transferase RFWD2; RING finger protein 200; RING finger and WD repeat domain protein 2; E3 ubiquitinprotein ligase RFWD2; Constitutive photomorphogenesis protein 1 homolog; COP1 | ||||
Target Type | Successful Target | ||||
Gene Name | RFWD2 | ||||
Biochemical Class | Acyltransferase | ||||
UniProt ID | |||||
Target Interacting Proteins | |||||
Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Protein Name | E3 ubiquitin-protein ligase RBX1 (RBX1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BA554C12.1; RNF75; ROC1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
COP9 signalosomes | [+] 2 COP9 signalosomes | + | |||
Interacting Protein Name | COP9 signalosome complex subunit 2 (COPS2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ALIEN; CSN2; SGN2; TRIP15 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Co-fractionation | [3] | |||
Interacting Protein Name | COP9 signalosome complex subunit 8 (COPS8) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | COP9; CSN8; SGN8 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Co-fractionation | [3] | |||
Cullins | [+] 1 Cullins | + | |||
Interacting Protein Name | Cullin-4A (CUL4A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
Kinases | [+] 2 Kinases | + | |||
Interacting Protein Name | Tribbles homolog 1 (TRIB1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | C8FW; GIG.2; GIG2; SKIP1; TRB.1; TRB1 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
2 | Co-crystal Structure | [5] | |||
3 | Protein-peptide | [5] | |||
Interacting Protein Name | Tribbles homolog 3 (TRIB3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | C20orf97; NIPK; SINK; SKIP3; TRB3 | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
Membrane-bounded channels | [+] 1 Membrane-bounded channels | + | |||
Interacting Protein Name | Major vault protein (MVP) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | LRP; VAULT1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [4] | |||
2 | Affinity Capture-Western | [7] | |||
Peptidases | [+] 1 Peptidases | + | |||
Interacting Protein Name | COP9 signalosome complex subunit 6 (COPS6) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CSN6; MOV34.34KD | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [8] | |||
Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [9] | |||
2 | Biochemical Activity | [10] | |||
Transcription regulators | [+] 4 Transcription regulators | + | |||
Interacting Target Name | Transcription factor AP-1 (JUN) | Discontinued Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [11] | |||
2 | Affinity Capture-Western | [2] | |||
Interacting Protein Name | ETS translocation variant 1 (ETV1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ER81 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
2 | Affinity Capture-Western | [12] | |||
Interacting Protein Name | ETS translocation variant 4 (ETV4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E1A.F; E1AF; PEA3; PEAS3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
2 | Affinity Capture-Western | [12] | |||
Interacting Protein Name | ETS translocation variant 5 (ETV5) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | ERM | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
2 | Affinity Capture-Western | [12] | |||
Ubiquitin related proteins | [+] 2 Ubiquitin related proteins | + | |||
Interacting Protein Name | DET1 homolog (DET1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
2 | Affinity Capture-Western | [2] | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Reconstituted Complex | [8] | |||
Other proteins | [+] 6 Other proteins | + | |||
Interacting Protein Name | T-complex protein 1 subunit delta (CCT4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CCT.DELTA; Cctd; SRB | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [13] | |||
2 | Affinity Capture-Western | [14] | |||
3 | Biochemical Activity | [14] | |||
Interacting Protein Name | DNA damage-binding protein 1 (DDB1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | DDBA; UV.DDB1; XAP1; XPCE; XPE; XPE.BF | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
Interacting Protein Name | T-complex protein 1 subunit beta (CCT2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | 99D8.1; CCT.beta; CCTB; HEL.S.100n; PRO1633; TCP.1.beta | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [13] | |||
Interacting Protein Name | T-complex protein 1 subunit gamma (CCT3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CCT.gamma; CCTG; PIG48; TCP.1.gamma; TRIC5 | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [13] | |||
Interacting Protein Name | T-complex protein 1 subunit eta (CCT7) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CCTETA; CCTH; NIP7.1; TCP1ETA | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [13] | |||
Interacting Protein Name | T-complex protein 1 subunit zeta (CCT6A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CCT.zeta; CCT.zeta.1; CCT6; Cctz; HTR3; MoDP.2; TCP.1.zeta; TCP20; TCPZ; TTCP20 | ||||
Evidence Score (E-score) | 1 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [13] | |||
References | |||||
REF 1 | An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. J Cell Sci. 2009 Apr 1;122(Pt 7):1035-44. | ||||
REF 2 | Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science. 2004 Feb 27;303(5662):1371-4. | ||||
REF 3 | An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biol. 2002 Dec 4;3:30. | ||||
REF 4 | Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014 Aug 11;26(2):222-34. | ||||
REF 5 | Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure. 2016 May 3;24(5):687-696. | ||||
REF 6 | COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 May 15;474(7351):403-6. | ||||
REF 7 | Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells. Cancer Res. 2005 Jul 1;65(13):5835-40. | ||||
REF 8 | COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3. Oncogene. 2011 Dec 1;30(48):4791-801. | ||||
REF 9 | ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science. 2006 Aug 25;313(5790):1122-6. | ||||
REF 10 | The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature. 2004 May 6;429(6987):86-92. | ||||
REF 11 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 12 | The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity. Oncogene. 2010 Mar 25;29(12):1810-20. | ||||
REF 13 | Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cells. Int J Biochem Cell Biol. 2006;38(7):1076-83. | ||||
REF 14 | Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC. Mol Cell Biol. 2014 Feb;34(4):643-52. |
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