Target General Information
Target ID T12819 Target Info
Target Name E3 ubiquitin-protein ligase COP1 (RFWD2)
Synonyms hCOP1; RNF200; RING-type E3 ubiquitin transferase RFWD2; RING finger protein 200; RING finger and WD repeat domain protein 2; E3 ubiquitinprotein ligase RFWD2; Constitutive photomorphogenesis protein 1 homolog; COP1
Target Type Successful Target
Gene Name RFWD2
Biochemical Class Acyltransferase
UniProt ID
COP1_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RBX1 (RBX1) Interacting Protein Interacting Protein Info
UniProt ID
RBX1_HUMAN 
Synonyms BA554C12.1; RNF75; ROC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
COP9 signalosomes [+] 2 COP9 signalosomes +
Interacting Protein Name COP9 signalosome complex subunit 2 (COPS2) Interacting Protein Interacting Protein Info
UniProt ID
CSN2_HUMAN 
Synonyms ALIEN; CSN2; SGN2; TRIP15
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [3]
Interacting Protein Name COP9 signalosome complex subunit 8 (COPS8) Interacting Protein Interacting Protein Info
UniProt ID
CSN8_HUMAN 
Synonyms COP9; CSN8; SGN8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [3]
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-4A (CUL4A) Interacting Protein Interacting Protein Info
UniProt ID
CUL4A_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Kinases [+] 2 Kinases +
Interacting Protein Name Tribbles homolog 1 (TRIB1) Interacting Protein Interacting Protein Info
UniProt ID
TRIB1_HUMAN 
Synonyms C8FW; GIG.2; GIG2; SKIP1; TRB.1; TRB1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Co-crystal Structure [5]
3 Protein-peptide [5]
Interacting Protein Name Tribbles homolog 3 (TRIB3) Interacting Protein Interacting Protein Info
UniProt ID
TRIB3_HUMAN 
Synonyms C20orf97; NIPK; SINK; SKIP3; TRB3
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [6]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Major vault protein (MVP) Interacting Protein Interacting Protein Info
UniProt ID
MVP_HUMAN 
Synonyms LRP; VAULT1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [7]
Peptidases [+] 1 Peptidases +
Interacting Protein Name COP9 signalosome complex subunit 6 (COPS6) Interacting Protein Interacting Protein Info
UniProt ID
CSN6_HUMAN 
Synonyms CSN6; MOV34.34KD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [10]
Transcription regulators [+] 4 Transcription regulators +
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [2]
Interacting Protein Name ETS translocation variant 1 (ETV1) Interacting Protein Interacting Protein Info
UniProt ID
ETV1_HUMAN 
Synonyms ER81
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [12]
Interacting Protein Name ETS translocation variant 4 (ETV4) Interacting Protein Interacting Protein Info
UniProt ID
ETV4_HUMAN 
Synonyms E1A.F; E1AF; PEA3; PEAS3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [12]
Interacting Protein Name ETS translocation variant 5 (ETV5) Interacting Protein Interacting Protein Info
UniProt ID
ETV5_HUMAN 
Synonyms ERM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [12]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Protein Name DET1 homolog (DET1) Interacting Protein Interacting Protein Info
UniProt ID
DET1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [2]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Interacting Protein Interacting Protein Info
UniProt ID
UB2D1_HUMAN 
Synonyms E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A
Evidence Score (E-score) 1 Experimental Evidences +
1 Reconstituted Complex [8]
Other proteins [+] 6 Other proteins +
Interacting Protein Name T-complex protein 1 subunit delta (CCT4) Interacting Protein Interacting Protein Info
UniProt ID
TCPD_HUMAN 
Synonyms CCT.DELTA; Cctd; SRB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [14]
3 Biochemical Activity [14]
Interacting Protein Name DNA damage-binding protein 1 (DDB1) Interacting Protein Interacting Protein Info
UniProt ID
DDB1_HUMAN 
Synonyms DDBA; UV.DDB1; XAP1; XPCE; XPE; XPE.BF
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Interacting Protein Name T-complex protein 1 subunit beta (CCT2) Interacting Protein Interacting Protein Info
UniProt ID
TCPB_HUMAN 
Synonyms 99D8.1; CCT.beta; CCTB; HEL.S.100n; PRO1633; TCP.1.beta
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [13]
Interacting Protein Name T-complex protein 1 subunit gamma (CCT3) Interacting Protein Interacting Protein Info
UniProt ID
TCPG_HUMAN 
Synonyms CCT.gamma; CCTG; PIG48; TCP.1.gamma; TRIC5
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [13]
Interacting Protein Name T-complex protein 1 subunit eta (CCT7) Interacting Protein Interacting Protein Info
UniProt ID
TCPH_HUMAN 
Synonyms CCTETA; CCTH; NIP7.1; TCP1ETA
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [13]
Interacting Protein Name T-complex protein 1 subunit zeta (CCT6A) Interacting Protein Interacting Protein Info
UniProt ID
TCPZ_HUMAN 
Synonyms CCT.zeta; CCT.zeta.1; CCT6; Cctz; HTR3; MoDP.2; TCP.1.zeta; TCP20; TCPZ; TTCP20
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [13]
References
REF 1 An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. J Cell Sci. 2009 Apr 1;122(Pt 7):1035-44.
REF 2 Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science. 2004 Feb 27;303(5662):1371-4.
REF 3 An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biol. 2002 Dec 4;3:30.
REF 4 Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014 Aug 11;26(2):222-34.
REF 5 Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure. 2016 May 3;24(5):687-696.
REF 6 COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 May 15;474(7351):403-6.
REF 7 Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells. Cancer Res. 2005 Jul 1;65(13):5835-40.
REF 8 COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3. Oncogene. 2011 Dec 1;30(48):4791-801.
REF 9 ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science. 2006 Aug 25;313(5790):1122-6.
REF 10 The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature. 2004 May 6;429(6987):86-92.
REF 11 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 12 The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity. Oncogene. 2010 Mar 25;29(12):1810-20.
REF 13 Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cells. Int J Biochem Cell Biol. 2006;38(7):1076-83.
REF 14 Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC. Mol Cell Biol. 2014 Feb;34(4):643-52.

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