Target General Information
Target ID T14597 Target Info
Target Name Erbb2 tyrosine kinase receptor (HER2)
Synonyms p185erbB2; Tyrosine kinase-type cell surface receptor HER2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; NGL; NEU; Metastatic lymph node gene 19 protein; MLN19; MLN 19; HER2; CD340
Target Type Successful Target
Gene Name ERBB2
Biochemical Class Kinase
UniProt ID
ERBB2_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Protein-peptide [5]
4 Reconstituted Complex [6]
Interacting Protein Name Erbin (ERBIN) Interacting Protein Interacting Protein Info
UniProt ID
ERBIN_HUMAN 
Synonyms ERBIN; HEL.S.78; LAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Yeast two hybrid [8]
Cytokine receptors [+] 1 Cytokine receptors +
Interacting Target Name Oncostatin-M-specific receptor beta (OSMR) Literature-reported Target Interacting Protein Info
UniProt ID
OSMR_HUMAN 
Synonyms OSMRB; Oncostatin-M-specific receptor subunit beta; Interleukin-31 receptor subunit beta; IL-31R-beta; IL-31RB; IL-31R subunit beta; IL-31 receptor subunit beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Co-localization [10]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [11]
3 Protein-peptide [5]
4 Yeast two hybrid [12]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [13]
2 Affinity Capture-Western [14]
Kinases [+] 9 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [16]
3 Co-localization [17]
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [5]
2 Reconstituted Complex [18]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [19]
Interacting Target Name Erbb3 tyrosine kinase receptor (Erbb-3) Clinical trial Target Interacting Protein Info
UniProt ID
ERBB3_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB-3 protein; C-erbB3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Co-localization [10]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Co-localization [10]
Interacting Target Name Focal adhesion kinase 2 (PTK2B) Literature-reported Target Interacting Protein Info
UniProt ID
FAK2_HUMAN 
Synonyms Related adhesion focal tyrosine kinase; RAFTK; PYK2; Protein-tyrosine kinase 2-beta; Proline-rich tyrosine kinase 2; FAK2; FADK 2; Cell adhesion kinase beta; Calcium-regulated non-receptor proline-rich tyrosine kinase; Calcium-dependent tyrosine kinase; CAK-beta; CAKB; CADTK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Co-localization [10]
Interacting Target Name Tyrosine-protein kinase ABL2 (ABL2) Literature-reported Target Interacting Protein Info
UniProt ID
ABL2_HUMAN 
Synonyms Tyrosine-protein kinase ARG; ARG; ABLL; Abelson-related gene protein; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Far Western [18]
2 Protein-peptide [5]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Protein-peptide [5]
Interacting Protein Name DNA-directed RNA polymerase I subunit RPA2 (POLR1B) Interacting Protein Interacting Protein Info
UniProt ID
RPA2_HUMAN 
Synonyms RPA135; RPA2; Rpo1.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-Western [24]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Protein-peptide [5]
Other proteins [+] 4 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Co-localization [25]
3 Far Western [26]
4 Reconstituted Complex [26]
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Protein-peptide [5]
4 Yeast two hybrid [12]
Interacting Target Name Mucin-1 (MUC1) Clinical trial Target Interacting Protein Info
UniProt ID
MUC1_HUMAN 
Synonyms Tumour-associated antigen mucin 1; Tumor-associated mucin; Tumor-associated epithelial membraneantigen; Tumor-associated epithelial membrane antigen; PUM; Polymorphic epithelial mucin; PEMT; PEM; Peanut-reactive urinary mucin; Mucin-1; MUC-1; Krebs von den Lungen-6; KL-6; H23AG; Episialin; EMA; CD227 antigen; CD227; Carcinoma-associated mucin; Cancer antigen 15-3; CA 15-3; Breast carcinoma-associated antigen DF3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Co-localization [27]
Interacting Target Name Junction plakoglobin (JUP) Literature-reported Target Interacting Protein Info
UniProt ID
PLAK_HUMAN 
Synonyms Plakoglobin; DP3; Desmoplakin-3; Desmoplakin III; CTNNG; Catenin gamma
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [10]
2 Far Western [26]
References
REF 1 Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12847-52.
REF 2 Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. Biochim Biophys Acta. 2007 Mar;1773(3):383-90.
REF 3 Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1:2005.0008.
REF 4 ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol Cell Biol. 1998 Sep;18(9):5042-51.
REF 5 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 6 Degradation of HER2 by Cbl-based chimeric ubiquitin ligases. Cancer Res. 2007 Sep 15;67(18):8716-24.
REF 7 Erbin suppresses the MAP kinase pathway. J Biol Chem. 2003 Jan 10;278(2):1108-14.
REF 8 The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. J Biol Chem. 2001 May 4;276(18):15256-63.
REF 9 An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells. Oncogene. 2002 Jan 17;21(3):460-74.
REF 10 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 11 Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J Biol Chem. 1998 Oct 9;273(41):26954-61.
REF 12 A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360.
REF 13 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 14 Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem. 2001 Feb 2;276(5):3702-8.
REF 15 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol Syst Biol. 2013 Nov 5;9:705.
REF 16 The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane. Mol Biol Cell. 2005 Dec;16(12):5832-42.
REF 17 HER2 signaling regulates HER2 localization and membrane retention. PLoS One. 2017 Apr 3;12(4):e0174849.
REF 18 Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal. 2009 Jul;21(7):1143-50.
REF 19 ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. J Biol Chem. 2002 Oct 11;277(41):38486-93.
REF 20 Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia. 2005 Aug 15;51(3):217-28.
REF 21 Neuregulin-1 enhances motility and migration of human astrocytic glioma cells. J Biol Chem. 2003 Jun 6;278(23):20971-8.
REF 22 RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene. 2000 Mar 2;19(10):1318-28.
REF 23 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 24 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res. 2011 Jun 15;71(12):4269-79.
REF 25 ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas. J Biol Chem. 2002 Jun 21;277(25):22692-8.
REF 26 c-erbB-2 gene product directly associates with beta-catenin and plakoglobin. Biochem Biophys Res Commun. 1995 Mar 28;208(3):1067-72.
REF 27 Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. Mol Cancer Res. 2003 Aug;1(10):765-75.

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