Target General Information
Target ID T16514 Target Info
Target Name Fatty acid synthase (FASN)
Synonyms Yeast fatty acid synthase; Fatty-acyl-CoA synthase; Fatty acyl-CoA synthetase enzyme; FAS
Target Type Successful Target
Gene Name FASN
Biochemical Class Acyltransferase
UniProt ID
FAS_HUMAN 
Target Interacting Proteins
Peptidases [+] 1 Peptidases +
Interacting Target Name Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Literature-reported Target Interacting Protein Info
UniProt ID
UBP2_HUMAN 
Synonyms UBP41; Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [1]
References
REF 1 The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004 Mar;5(3):253-61.
REF 2 The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle. 2012 Mar 15;11(6):1123-30.

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