Target General Information
Target ID T25005 Target Info
Target Name Tyrosine-protein kinase BTK (ATK)
Synonyms Bruton's tyrosine kinase; Bruton tyrosine kinase; BPK; B-cell progenitor kinase; B cell progenitor kinase; Agammaglobulinemia tyrosine kinase; Agammaglobulinaemia tyrosine kinase; AGMX1
Target Type Successful Target
Gene Name BTK
Biochemical Class Kinase
UniProt ID
BTK_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-crystal Structure [2]
3 Protein-peptide [3]
4 Reconstituted Complex [4]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Yeast two hybrid [6]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name General transcription factor II-I (GTF2I) Interacting Protein Interacting Protein Info
UniProt ID
GTF2I_HUMAN 
Synonyms BAP135; BTKAP1; DIWS; GTFII.I; IB291; SPIN; TFII.I; WBS; WBSCR6
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
3 Reconstituted Complex [7]
4 Reconstituted Complex [9]
5 Reconstituted Complex [10]
Other proteins [+] 3 Other proteins +
Interacting Target Name Wiskott-Aldrich syndrome protein (WAS) Clinical trial Target Interacting Protein Info
UniProt ID
WASP_HUMAN 
Synonyms WASp; IMD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [11]
Interacting Protein Name B-cell linker protein (BLNK) Interacting Protein Interacting Protein Info
UniProt ID
BLNK_HUMAN 
Synonyms AGM4; BASH; BLNK.S; LY57; SLP.65; SLP65; bca
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [13]
Interacting Protein Name Inhibitor of Bruton tyrosine kinase (IBTK) Interacting Protein Interacting Protein Info
UniProt ID
IBTK_HUMAN 
Synonyms BTBD26; BTKI
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
References
REF 1 The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. Eur J Immunol. 1999 Jul;29(7):2269-79.
REF 2 Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl. J Biomol NMR. 2000 Apr;16(4):303-12.
REF 3 SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl. Proteins. 1997 Dec;29(4):545-52.
REF 4 The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med. 1995 Aug 1;182(2):611-5.
REF 5 Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9.
REF 6 A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
REF 7 Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I. J Biol Chem. 2004 Feb 20;279(8):7147-58.
REF 8 Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I. J Biol Chem. 2001 Jul 27;276(30):27806-15.
REF 9 BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):604-9.
REF 10 Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes. Int Immunol. 2004 May;16(5):747-57.
REF 11 Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J Immunol. 1996 Nov 1;157(9):3791-5.
REF 12 Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood. 1999 Oct 1;94(7):2357-64.
REF 13 Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med. 2002 Jul 1;196(1):51-63.
REF 14 Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. Nucleic Acids Res. 2008 Aug;36(13):4402-16.
REF 15 Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Nat Immunol. 2001 Oct;2(10):939-46.

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