Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T27819 Target Info
Target Name Mitotic checkpoint protein (MAD1L1)
Synonyms hMAD1; Tax-binding protein 181; TXBP181; Mitotic spindle assembly checkpoint protein MAD1; Mitotic checkpoint gene hMAD1; Mitotic checkpoint MAD1 protein homolog; Mitotic arrest deficient 1-like protein 1; MAD1-like protein 1; MAD1 (Mitotic arrest deficient, yeast, homolog)-like 1; MAD1; HsMAD1
Target Type Literature-reported Target
Gene Name MAD1L1
UniProt ID
MD1L1_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 1 Other proteins +
Interacting Protein Name Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) Interacting Protein Interacting Protein Info
UniProt ID
MD2L1_HUMAN 
Synonyms HSMAD2; MAD2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-purification [3]
4 Reconstituted Complex [4]
5 Yeast two hybrid [5]
6 Yeast two hybrid [6]
References  Top
REF 1 Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor. Cell. 2014 Feb 27;156(5):1017-31.
REF 2 Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein. J Biol Chem. 2014 Aug 22;289(34):23928-37.
REF 3 Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint. EMBO J. 2001 Nov 15;20(22):6371-82.
REF 4 Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol. 2008 Mar 4;6(3):e50.
REF 5 BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex. J Biol Chem. 2011 Jun 17;286(24):21173-9.
REF 6 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.

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