Target General Information
Target ID T35173 Target Info
Target Name Cellular inhibitor of apoptosis 2 (BIRC3)
Synonyms hIAP1; hIAP-1; TNFR2TRAFsignaling complex protein 1; TNFR2-TRAF-signaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; CIAP2; C-IAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Target Type Clinical trial Target
Gene Name BIRC3
Biochemical Class Acyltransferase
UniProt ID
BIRC3_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 3 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [3]
4 Co-localization [4]
5 Reconstituted Complex [2]
6 Yeast two hybrid [5]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
Interacting Protein Name TNF receptor-associated factor 3 (TRAF3) Interacting Protein Interacting Protein Info
UniProt ID
TRAF3_HUMAN 
Synonyms CAP.1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [7]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-localization [4]
3 Reconstituted Complex [8]
Kinases [+] 2 Kinases +
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [9]
3 Reconstituted Complex [9]
Interacting Protein Name Receptor-interacting protein 2 (RIP2) Interacting Protein Interacting Protein Info
UniProt ID
RIPK2_HUMAN 
Synonyms UNQ277/PRO314/PRO34092; Tyrosine-protein kinase RIPK2; RIP-like-interacting CLARP kinase; RIP-2; RIP2; RICK; Receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting protein 2; CARDIAK; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [9]
3 Reconstituted Complex [11]
Peptidases [+] 3 Peptidases +
Interacting Target Name Caspase-9 (CASP9) Clinical trial Target Interacting Protein Info
UniProt ID
CASP9_HUMAN 
Synonyms MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Co-localization [4]
3 Reconstituted Complex [12]
4 Yeast two hybrid [13]
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
Interacting Target Name Caspase-7 (CASP7) Clinical trial Target Interacting Protein Info
UniProt ID
CASP7_HUMAN 
Synonyms MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [15]
Ubiquitin related proteins [+] 4 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Co-crystal Structure [18]
3 Reconstituted Complex [18]
4 Yeast two hybrid [19]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Interacting Protein Interacting Protein Info
UniProt ID
UB2D1_HUMAN 
Synonyms E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [9]
3 Yeast two hybrid [19]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Interacting Protein Interacting Protein Info
UniProt ID
UB2D3_HUMAN 
Synonyms E2(17)KB3; UBC4/5; UBCH5C
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [20]
3 Yeast two hybrid [19]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [21]
2 Reconstituted Complex [22]
Other proteins [+] 3 Other proteins +
Interacting Target Name Direct IAP-binding protein with low pI (DIABLO) Literature-reported Target Interacting Protein Info
UniProt ID
DBLOH_HUMAN 
Synonyms Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Biochemical Activity [23]
3 Reconstituted Complex [24]
Interacting Protein Name B-cell lymphoma/leukemia 10 (BCL10) Interacting Protein Interacting Protein Info
UniProt ID
BCL10_HUMAN 
Synonyms CARMEN; CIPER; CLAP; IMD37; c.E10; mE10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Biochemical Activity [26]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [22]
References
REF 1 OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J. 2013 Apr 17;32(8):1103-14.
REF 2 Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell. 2010 Apr 9;38(1):101-13.
REF 3 IB kinase phosphorylates TRAF2 to promote mammary epithelial cell transformation. Mol Cell Biol. 2012 Dec;32(23):4756-68.
REF 4 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 5 Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-assoc... Proc Natl Acad Sci U S A. 1996 May 14;93(10):4974-8.
REF 6 K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5. Nat Immunol. 2014 Mar;15(3):231-8.
REF 7 Noncanonical NF-B activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif. Sci Signal. 2013 Apr 23;6(272):ra27.
REF 8 TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. 2002 Mar 21;416(6878):345-7.
REF 9 cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356.
REF 10 Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol. 1998 Jul 16;8(15):885-8.
REF 11 Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity. 2009 Jun 19;30(6):789-801.
REF 12 IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23.
REF 13 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 14 IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2006 Oct;2(10):e114.
REF 15 The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 1;16(23):6914-25.
REF 16 The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem. 2006 Feb 10;281(6):3254-60.
REF 17 Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60.
REF 18 Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. J Biol Chem. 2008 Nov 14;283(46):31633-40.
REF 19 c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209.
REF 20 Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ. 2011 Aug;18(8):1376-86.
REF 21 Gliotoxin suppresses NF-B activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem Biol. 2015 Mar 20;10(3):675-81.
REF 22 IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17.
REF 23 The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem. 2014 Sep 12;289(37):25721-36.
REF 24 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. J Biol Chem. 2004 Apr 23;279(17):16963-70.
REF 25 CIAP2 inhibits anigen receptor signaling by targeting Bcl10 for degredation. Cell Cycle. 2006 Jul;5(13):1438-42.
REF 26 cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin Invest. 2006 Jan;116(1):174-81.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.