Target Interacting Protein Information
Target General Information | |||||
---|---|---|---|---|---|
Target ID | T36557 | Target Info | |||
Target Name | Peroxisome proliferator-activated receptor delta (PPARD) | ||||
Synonyms | Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; PPARdelta; PPARB; PPAR-delta; PPAR-beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | PPARD | ||||
Biochemical Class | Nuclear hormone receptor | ||||
UniProt ID | |||||
Target Interacting Proteins | |||||
Acyltransferases | [+] 2 Acyltransferases | + | |||
Interacting Protein Name | Nuclear receptor coactivator 1 (NCOA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Reconstituted Complex | [1] | |||
2 | Reconstituted Complex | [2] | |||
3 | Reconstituted Complex | [3] | |||
4 | Yeast two hybrid | [4] | |||
Interacting Target Name | Histone acetyltransferase p300 (EP300) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Reconstituted Complex | [1] | |||
2 | Yeast two hybrid | [5] | |||
Carbon-nitrogen hydrolases | [+] 2 Carbon-nitrogen hydrolases | + | |||
Interacting Target Name | Histone deacetylase 2 (HDAC2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HD2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Co-localization | [7] | |||
Interacting Target Name | Histone deacetylase 3 (HDAC3) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | SMAP45; RPD3-2; RPD32; HD3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Reconstituted Complex | [8] | |||
Heat shock proteins | [+] 1 Heat shock proteins | + | |||
Interacting Target Name | Heat shock protein 90 alpha (HSP90A) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [9] | |||
2 | Yeast two hybrid | [10] | |||
Nuclear hormone receptors | [+] 3 Nuclear hormone receptors | + | |||
Interacting Target Name | Retinoic acid receptor RXR-alpha (RXRA) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [11] | |||
2 | Reconstituted Complex | [2] | |||
3 | Yeast two hybrid | [12] | |||
4 | Yeast two hybrid | [4] | |||
Interacting Target Name | Retinoic acid receptor RXR-gamma (RXRG) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [11] | |||
2 | Yeast two hybrid | [4] | |||
Interacting Target Name | Retinoic acid receptor RXR-beta (RXRB) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [11] | |||
2 | Yeast two hybrid | [4] | |||
Transcription regulators | [+] 2 Transcription regulators | + | |||
Interacting Protein Name | Nuclear receptor corepressor 1 (NCOR1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Reconstituted Complex | [13] | |||
2 | Reconstituted Complex | [3] | |||
3 | Yeast two hybrid | [6] | |||
Interacting Protein Name | Nuclear receptor corepressor 2 (NCOR2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Reconstituted Complex | [3] | |||
2 | Yeast two hybrid | [6] | |||
References | |||||
REF 1 | A simple method to screen ligands of peroxisome proliferator-activated receptor delta. Eur J Pharm Sci. 2006 Dec;29(5):355-60. | ||||
REF 2 | Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005 Jul 15;280(28):26543-56. | ||||
REF 3 | Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. Endocrinology. 2004 Jun;145(6):2886-95. | ||||
REF 4 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
REF 5 | PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):298-302. | ||||
REF 6 | The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2613-8. | ||||
REF 7 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
REF 8 | Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):1-12. | ||||
REF 9 | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001. | ||||
REF 10 | Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry. 2003 Sep 16;42(36):10726-35. | ||||
REF 11 | Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol Cancer Res. 2012 Mar;10(3):441-53. | ||||
REF 12 | Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta. PLoS One. 2009 Sep 16;4(9):e7046. | ||||
REF 13 | Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J. 2002 Apr 1;363(Pt 1):157-65. |
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