Target General Information
Target ID T36557 Target Info
Target Name Peroxisome proliferator-activated receptor delta (PPARD)
Synonyms Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; PPARdelta; PPARB; PPAR-delta; PPAR-beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
Target Type Clinical trial Target
Gene Name PPARD
Biochemical Class Nuclear hormone receptor
UniProt ID
PPARD_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
4 Yeast two hybrid [4]
Interacting Target Name Histone acetyltransferase p300 (EP300) Literature-reported Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [1]
2 Yeast two hybrid [5]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-localization [7]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [8]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [9]
2 Yeast two hybrid [10]
Nuclear hormone receptors [+] 3 Nuclear hormone receptors +
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [2]
3 Yeast two hybrid [12]
4 Yeast two hybrid [4]
Interacting Target Name Retinoic acid receptor RXR-gamma (RXRG) Successful Target Interacting Protein Info
UniProt ID
RXRG_HUMAN 
Synonyms Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Yeast two hybrid [4]
Interacting Target Name Retinoic acid receptor RXR-beta (RXRB) Successful Target Interacting Protein Info
UniProt ID
RXRB_HUMAN 
Synonyms Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Yeast two hybrid [4]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [13]
2 Reconstituted Complex [3]
3 Yeast two hybrid [6]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [3]
2 Yeast two hybrid [6]
References
REF 1 A simple method to screen ligands of peroxisome proliferator-activated receptor delta. Eur J Pharm Sci. 2006 Dec;29(5):355-60.
REF 2 Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005 Jul 15;280(28):26543-56.
REF 3 Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. Endocrinology. 2004 Jun;145(6):2886-95.
REF 4 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 5 PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):298-302.
REF 6 The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2613-8.
REF 7 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 8 Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):1-12.
REF 9 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 10 Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry. 2003 Sep 16;42(36):10726-35.
REF 11 Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol Cancer Res. 2012 Mar;10(3):441-53.
REF 12 Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta. PLoS One. 2009 Sep 16;4(9):e7046.
REF 13 Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J. 2002 Apr 1;363(Pt 1):157-65.

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