Target General Information
Target ID T57700 Target Info
Target Name Tyrosine-protein kinase Kit (KIT)
Synonyms v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; p145 c-kit; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; Mast/stem cell growth factor receptor Kit; CD117 antigen; CD117; C-kit
Target Type Successful Target
Gene Name KIT
Biochemical Class Kinase
UniProt ID
KIT_HUMAN 
Target Interacting Proteins
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Yeast two hybrid [3]
Ester hydrolases [+] 3 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [4]
2 Reconstituted Complex [5]
Interacting Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6) Patented-recorded Target Interacting Protein Info
UniProt ID
PTN6_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [8]
2 Reconstituted Complex [9]
Kinases [+] 2 Kinases +
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [2]
3 Co-localization [8]
4 Reconstituted Complex [9]
5 Yeast two hybrid [3]
6 Yeast two hybrid [11]
Interacting Target Name Tyrosine-protein kinase Tec (PSCTK4) Patented-recorded Target Interacting Protein Info
UniProt ID
TEC_HUMAN 
Synonyms Tec protein tyrosine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [12]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Co-localization [8]
3 Reconstituted Complex [13]
Other proteins [+] 1 Other proteins +
Interacting Target Name Mast cell growth factor (MGF) Literature-reported Target Interacting Protein Info
UniProt ID
SCF_HUMAN 
Synonyms Stem cell factor; Soluble KIT ligand; sKITLG; SCF; Kit ligand; c-Kit ligand; cKit ligand
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
References
REF 1 Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res. 2007 Nov 1;313(18):3935-42.
REF 2 KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance. Oncogene. 2007 Sep 27;26(44):6386-95.
REF 3 Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 1999 Feb 15;18(4):904-15.
REF 4 The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem J. 2003 Mar 15;370(Pt 3):1033-8.
REF 5 The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J Biol Chem. 1994 Oct 7;269(40):25206-11.
REF 6 SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol. 1998 Apr;18(4):2089-99.
REF 7 Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. Mol Cell Biol. 1993 Jun;13(6):3350-8.
REF 8 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 9 Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood. 2000 Nov 15;96(10):3406-13.
REF 10 Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells. J Biol Chem. 1994 Feb 25;269(8):6026-30.
REF 11 Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. Oncogene. 1997 Jul 3;15(1):7-15.
REF 12 Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol Cell Biol. 1994 Dec;14(12):8432-7.
REF 13 Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem J. 1997 Oct 1;327 ( Pt 1):73-80.
REF 14 A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses. J Biol Chem. 1992 May 25;267(15):10866-73.
REF 15 Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. J Biol Chem. 1993 Feb 25;268(6):4399-406.

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