Target General Information
Target ID T58921 Target Info
Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Synonyms PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Target Type Successful Target
Gene Name PPARG
Biochemical Class Nuclear hormone receptor
UniProt ID
PPARG_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 5 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Literature-reported Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Fluorescence Resonance Energy Transfer [2]
3 Protein-peptide [3]
4 Reconstituted Complex [1]
5 Yeast two hybrid [1]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 4 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
3 Reconstituted Complex [4]
4 Yeast two hybrid [5]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 3 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
3 Reconstituted Complex [4]
Interacting Target Name Tripartite motif-containing 24 (TRIM24) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1A_HUMAN 
Synonyms Tripartite motif-containing protein 24; Transcription intermediary factor 1-alpha; TIF1-alpha; TIF1A; TIF1; RNF82; RING-type E3 ubiquitin transferase TIF1-alpha; RING finger protein 82; E3 ubiquitin-protein ligase TRIM24
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [6]
Interacting Protein Name Histone acetyltransferase KAT5 (KAT5) Interacting Protein Interacting Protein Info
UniProt ID
KAT5_HUMAN 
Synonyms ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5; cPLA2
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [6]
2 Reconstituted Complex [7]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Caveolin 1 (CAV1) Literature-reported Target Interacting Protein Info
UniProt ID
CAV1_HUMAN 
Synonyms Caveolin-1; Caveolin1; Cav-1; CAV
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Co-fractionation [8]
3 Co-localization [8]
4 Yeast two hybrid [8]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 4 (HDAC4) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC4_HUMAN 
Synonyms KIAA0288; HD4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [10]
Kinases [+] 2 Kinases +
Interacting Target Name ERK activator kinase 1 (MEK1) Clinical trial Target Interacting Protein Info
UniProt ID
MP2K1_HUMAN 
Synonyms PRKMK1; MKK1; Mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERKkinase 1; MAPK/ERK kinase 1; MAP kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Co-fractionation [8]
3 Reconstituted Complex [12]
Interacting Target Name Cyclin-dependent kinase 5 (CDK5) Patented-recorded Target Interacting Protein Info
UniProt ID
CDK5_HUMAN 
Synonyms TPKII catalytic subunit; Tau protein kinase II catalytic subunit; Serine/threonine-protein kinase PSSALRE; Serine/threonine protein kinase PSSALRE; Proline-directed protein kinase F(A) (PDPK F(A)); Proline-directed protein kinase 33 kDa subunit; PDPK; Cyclin-dependent-like kinase 5; Cyclin-dependent kinase 5 (CDK5); Cell division protein kinase 5; CDKN5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Biochemical Activity [14]
Mediator complexes [+] 1 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 4 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
3 Reconstituted Complex [4]
4 Yeast two hybrid [15]
Nuclear hormone receptors [+] 4 Nuclear hormone receptors +
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [17]
3 Co-crystal Structure [18]
4 Co-localization [19]
5 Reconstituted Complex [20]
6 Yeast two hybrid [21]
Interacting Target Name Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B2_HUMAN 
Synonyms Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Protein-peptide [3]
3 Reconstituted Complex [22]
Interacting Target Name Retinoic acid receptor RXR-beta (RXRB) Successful Target Interacting Protein Info
UniProt ID
RXRB_HUMAN 
Synonyms Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [23]
Interacting Target Name Orphan nuclear receptor DAX-1 (NR0B1) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B1_HUMAN 
Synonyms Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1; DSS-AHC critical region on the X chromosome protein 1; DAX1; AHC
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [3]
2 Reconstituted Complex [24]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C) Interacting Protein Interacting Protein Info
UniProt ID
JHD2C_HUMAN 
Synonyms TRIP8
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
Transcription regulators [+] 10 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Co-localization [25]
3 Fluorescence Resonance Energy Transfer [26]
4 Protein-peptide [3]
5 Reconstituted Complex [27]
6 Yeast two hybrid [13]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Co-localization [25]
3 Protein-peptide [3]
4 Yeast two hybrid [21]
Interacting Protein Name PPAR-gamma coactivator 1-alpha (PPARGC1A) Interacting Protein Interacting Protein Info
UniProt ID
PRGC1_HUMAN 
Synonyms LEM6; PGC.1(alpha); PGC.1v; PGC1; PGC1A; PPARGC1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Protein-peptide [3]
3 Reconstituted Complex [29]
4 Yeast two hybrid [15]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [31]
3 Reconstituted Complex [30]
4 Yeast two hybrid [32]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-peptide [3]
2 Reconstituted Complex [33]
3 Yeast two hybrid [34]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 3 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
3 Yeast two hybrid [15]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Reconstituted Complex [36]
Interacting Target Name CCAAT/enhancer binding protein beta (CEBPB) Literature-reported Target Interacting Protein Info
UniProt ID
CEBPB_HUMAN 
Synonyms Transcription factor CCAAT/enhancer-binding protein beta; Transcription factor 5; TCF-5; TCF5; PP9092; Nuclear factor NF-IL6; Liver-enriched inhibitory protein; Liver activator protein; LIP; LAP; CCAAT/enhancer-binding protein beta; C/EBP beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Reconstituted Complex [36]
Interacting Target Name High mobility group protein HMG-I/Y (HMGA1) Literature-reported Target Interacting Protein Info
UniProt ID
HMGA1_HUMAN 
Synonyms HMGIY; HMG-I(Y); High mobility group protein R; High mobility group protein HMG-I/HMG-Y; High mobility group protein A1; High mobility group AT-hook protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [36]
2 Yeast two hybrid [38]
Interacting Protein Name Activating signal cointegrator 1 (TRIP4) Interacting Protein Interacting Protein Info
UniProt ID
TRIP4_HUMAN 
Synonyms ASC.1; ASC1; HsT17391; ZC2HC5
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
Other proteins [+] 5 Other proteins +
Interacting Target Name Nuclear receptor coactivator 4 (NCOA4) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA4_HUMAN 
Synonyms RFG; Ret-activating protein ELE1; Nuclear receptor coactivator 4; NCoA-4; ELE1; ARA70 (dARA70N); ARA70; Androgen receptor-associated protein of 70 kDa; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-peptide [6]
2 Reconstituted Complex [5]
3 Yeast two hybrid [5]
Interacting Protein Name Nuclear receptor-interacting protein 1 (NRIP1) Interacting Protein Interacting Protein Info
UniProt ID
NRIP1_HUMAN 
Synonyms RIP140
Evidence Score (E-score) 3 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
3 Reconstituted Complex [39]
Interacting Protein Name Zinc finger HIT domain-containing protein 3 (ZNHIT3) Interacting Protein Interacting Protein Info
UniProt ID
ZNHI3_HUMAN 
Synonyms TRIP3
Evidence Score (E-score) 3 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [2]
2 Protein-peptide [3]
3 Reconstituted Complex [3]
Interacting Protein Name Glutamate receptor-interacting protein 1 (GRIP1) Interacting Protein Interacting Protein Info
UniProt ID
GRIP1_HUMAN 
Synonyms GRIP
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [4]
2 Yeast two hybrid [40]
Interacting Protein Name Nuclear receptor coactivator 6 (NCOA6) Interacting Protein Interacting Protein Info
UniProt ID
NCOA6_HUMAN 
Synonyms AIB3; ASC2; NRC; PRIP; RAP250; TRBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Protein-peptide [3]
References
REF 1 p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. J Biol Chem. 1999 Mar 19;274(12):7681-8.
REF 2 Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres. Cytometry. 2001 Aug 1;44(4):326-37.
REF 3 Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics. 2009 Oct;8(10):2212-26.
REF 4 Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators. Mol Cell Biol. 2000 Nov;20(21):8008-17.
REF 5 Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. J Biol Chem. 1999 Jun 4;274(23):16147-52.
REF 6 T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57.
REF 7 The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma. Endocrinology. 2008 Apr;149(4):1840-9.
REF 8 The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor through spatial relocalization at helix 7 of its ligand-binding domain. Mol Cell Biol. 2011 Aug;31(16):3497-510.
REF 9 Peroxisome proliferator-activated receptor is inhibited by histone deacetylase 4 in cortical neurons under oxidative stress. J Neurochem. 2011 Aug;118(3):429-39.
REF 10 Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):1-12.
REF 11 The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell. 2002 Dec;3(6):903-10.
REF 12 Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol. 2007 Feb;27(3):803-17.
REF 13 Adipocyte NCoR knockout decreases PPAR phosphorylation and enhances PPAR activity and insulin sensitivity. Cell. 2011 Nov 11;147(4):815-26.
REF 14 GQ-16, a novel peroxisome proliferator-activated receptor (PPAR) ligand, promotes insulin sensitization without weight gain. J Biol Chem. 2012 Aug 10;287(33):28169-79.
REF 15 A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. Mol Cancer Ther. 2004 Mar;3(3):247-60.
REF 16 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 17 Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 2008 Jan;99(1):86-95.
REF 18 Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008 Nov 20;456(7220):350-6.
REF 19 Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells. Hepatology. 2013 Nov;58(5):1681-92.
REF 20 PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998 Apr 17;93(2):241-52.
REF 21 A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. Endocrinology. 2009 Feb;150(2):862-70.
REF 22 Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. J Biol Chem. 2002 Jan 11;277(2):1586-92.
REF 23 Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol Cancer Res. 2012 Mar;10(3):441-53.
REF 24 The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPARgamma. Biochem Biophys Res Commun. 2008 May 30;370(2):264-8.
REF 25 Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 2005 Feb 15;19(4):453-61.
REF 26 The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem. 2007 Jun 29;282(26):19152-66.
REF 27 Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J. 2002 Apr 1;363(Pt 1):157-65.
REF 28 Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma. FEBS Lett. 2009 Sep 3;583(17):2720-6.
REF 29 Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell. 2003 Nov;12(5):1137-49.
REF 30 Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta. J Cell Biochem. 2003 Nov 1;90(4):732-44.
REF 31 PPAR is an E3 ligase that induces the degradation of NFB/p65. Nat Commun. 2012;3:1300.
REF 32 Hypoxia downregulates PPAR via an ERK1/2-NF-B-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells. Free Radic Biol Med. 2013 Oct;63:151-60.
REF 33 Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol. 2000 Jul;20(13):4699-707.
REF 34 A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. Anal Biochem. 2004 Dec 15;335(2):253-9.
REF 35 Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma). PLoS One. 2010 Mar 29;5(3):e9912.
REF 36 The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists. Endocr Relat Cancer. 2008 Mar;15(1):325-35.
REF 37 Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. Blood. 2007 Dec 15;110(13):4373-84.
REF 38 Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. J Biol Chem. 1999 Aug 6;274(32):22563-8.
REF 39 A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol. 1998 Jun;12(6):864-81.
REF 40 S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects. Diabetes. 2007 Nov;56(11):2797-808.
REF 41 H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013 Dec 24;2:e01503.

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