Target General Information
Target ID T59328 Target Info
Target Name Epidermal growth factor receptor (EGFR)
Synonyms Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
Target Type Successful Target
Gene Name EGFR
Biochemical Class Kinase
UniProt ID
EGFR_HUMAN 
Target Interacting Proteins
Acid anhydride hydrolases [+] 5 Acid anhydride hydrolases +
Interacting Protein Name ADP-ribosylation factor 6 (ARF6) Interacting Protein Interacting Protein Info
UniProt ID
ARF6_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-Fragment Complementation Assay [2]
Interacting Protein Name GTP-binding protein RAD (RRAD) Interacting Protein Interacting Protein Info
UniProt ID
RAD_HUMAN 
Synonyms RAD; RAD1; REM3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [5]
Interacting Target Name Structural maintenance of chromosomes protein 2 (SMC2) Literature-reported Target Interacting Protein Info
UniProt ID
SMC2_HUMAN 
Synonyms XCAP-E homolog; SMC2L1; SMC-2; SMC protein 2; PRO0324; hCAP-E; Chromosome-associated protein E; CAPE
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name ADP-ribosylation factor-like protein 1 (ARL1) Interacting Protein Interacting Protein Info
UniProt ID
ARL1_HUMAN 
Synonyms ARFL1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Acyltransferases [+] 4 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
3 Co-crystal Structure [8]
4 Co-localization [9]
5 Reconstituted Complex [10]
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [12]
3 Protein-Fragment Complementation Assay [2]
4 Yeast two hybrid [13]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [14]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Serine palmitoyltransferase 1 (SPTLC1) Interacting Protein Interacting Protein Info
UniProt ID
SPTC1_HUMAN 
Synonyms HSAN1; HSN1; LBC1; LCB1; SPT1; SPTI
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [3]
Adapter proteins [+] 13 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [16]
3 Protein-Fragment Complementation Assay [11]
4 Protein-peptide [17]
5 Reconstituted Complex [10]
6 Yeast two hybrid [13]
Interacting Protein Name GRB2-associated-binding protein 1 (GAB1) Interacting Protein Interacting Protein Info
UniProt ID
GAB1_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [18]
3 Biochemical Activity [19]
4 Protein-Fragment Complementation Assay [11]
5 Yeast two hybrid [13]
Interacting Protein Name Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) Interacting Protein Interacting Protein Info
UniProt ID
BAIP2_HUMAN 
Synonyms BAP2; FLAF3; IRSP53
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [20]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Target Name NCK adaptor protein 1 (NCK1) Clinical trial Target Interacting Protein Info
UniProt ID
NCK1_HUMAN 
Synonyms SH2/SH3 adaptor protein NCK-alpha; SH2/SH3 adaptor protein NCKalpha; Nck-1; Nck1; NCK; Cytoplasmic protein NCK1
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Protein-peptide [17]
3 Yeast two hybrid [13]
Interacting Protein Name GRB2-related adapter protein 2 (GRAP2) Interacting Protein Interacting Protein Info
UniProt ID
GRAP2_HUMAN 
Synonyms GADS; GRAP.2; GRB2L; GRBLG; GRID; GRPL; GrbX; Grf40; Mona; P38
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Cytoplasmic protein NCK2 (NCK2) Interacting Protein Interacting Protein Info
UniProt ID
NCK2_HUMAN 
Synonyms GRB4; NCKbeta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name SH2B adapter protein 1 (SH2B1) Interacting Protein Interacting Protein Info
UniProt ID
SH2B1_HUMAN 
Synonyms PSM; SH2B
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Protein-peptide [17]
3 Yeast two hybrid [13]
Interacting Protein Name Src-like-adapter (SLA) Interacting Protein Interacting Protein Info
UniProt ID
SLAP1_HUMAN 
Synonyms SLA1; SLAP
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Protein-peptide [17]
3 Yeast two hybrid [13]
Interacting Protein Name Signal-transducing adaptor protein 2 (STAP2) Interacting Protein Interacting Protein Info
UniProt ID
STAP2_HUMAN 
Synonyms BKS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Growth factor receptor-bound protein 10 (GRB10) Interacting Protein Interacting Protein Info
UniProt ID
GRB10_HUMAN 
Synonyms GRB.IR; Grb.10; IRBP; MEG1; RSS
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Intersectin-2 (ITSN2) Interacting Protein Interacting Protein Info
UniProt ID
ITSN2_HUMAN 
Synonyms PRO2015; SH3D1B; SH3P18; SWA; SWAP
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Src-like-adapter 2 (SLA2) Interacting Protein Interacting Protein Info
UniProt ID
SLAP2_HUMAN 
Synonyms C20orf156; MARS; SLAP.2; SLAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Signal transducing adapter molecule 2 (STAM2) Interacting Protein Interacting Protein Info
UniProt ID
STAM2_HUMAN 
Synonyms Hbp; STAM2A; STAM2B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Reconstituted Complex [23]
Alkyl/aryl transferases [+] 1 Alkyl/aryl transferases +
Interacting Target Name Glutathione S-transferase P (GSTP1) Clinical trial Target Interacting Protein Info
UniProt ID
GSTP1_HUMAN 
Synonyms GSTP1-1; GSTP11; GST3; GST class-pi; GST classpi; FAEES3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Biochemical Activity [25]
Auxiliary transporters [+] 7 Auxiliary transporters +
Interacting Target Name Caveolin 1 (CAV1) Literature-reported Target Interacting Protein Info
UniProt ID
CAV1_HUMAN 
Synonyms Caveolin-1; Caveolin1; Cav-1; CAV
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-Western [27]
3 Protein-Fragment Complementation Assay [11]
4 Reconstituted Complex [27]
5 Yeast two hybrid [13]
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [6]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Alpha-actinin-4 (ACTN4) Interacting Protein Interacting Protein Info
UniProt ID
ACTN4_HUMAN 
Synonyms ACTININ.4; FSGS; FSGS1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [28]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Target Name S100 calcium-binding protein A4 (S100A4) Literature-reported Target Interacting Protein Info
UniProt ID
S10A4_HUMAN 
Synonyms Protein S100-A4; Protein Mts1; Placental calcium-binding protein; MTS1; Metastasin; CAPL; Calvasculin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Caveolin-2 (CAV2) Interacting Protein Interacting Protein Info
UniProt ID
CAV2_HUMAN 
Synonyms CAV
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Toll-like receptor 2 (TLR2) Clinical trial Target Interacting Protein Info
UniProt ID
TLR2_HUMAN 
Synonyms Toll/interleukin-1 receptor-like protein 4; TIL4; CD282
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Lymphocyte activation antigen 4F2 (SLC3A2) Clinical trial Target Interacting Protein Info
UniProt ID
4F2_HUMAN 
Synonyms SLC3A2; Lymphocyte activation antigen 4F2 large subunit; CD98; 4F2hc; 4F2 heavy chain antigen; 4F2 cellsurface antigen heavy chain
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-Western [26]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 6 (HDAC6) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC6_HUMAN 
Synonyms KIAA0901; JM21; HD6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [29]
3 Protein-Fragment Complementation Assay [2]
4 Yeast two hybrid [13]
Interacting Target Name Histone deacetylase 7 (HDAC7) Patented-recorded Target Interacting Protein Info
UniProt ID
HDAC7_HUMAN 
Synonyms Histone deacetylase 7A; HDAC7A; HD7a; HD7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Yeast two hybrid [13]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-Western [5]
Ester hydrolases [+] 12 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [31]
3 Biochemical Activity [32]
4 Protein-peptide [17]
5 Yeast two hybrid [3]
Interacting Protein Name Phosphoinositide phospholipase C-gamma-2 (PLCG2) Interacting Protein Interacting Protein Info
UniProt ID
PLCG2_HUMAN 
Synonyms APLAID; FCAS3; PLC.IV; PLC.gamma.2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Co-localization [33]
3 Protein-Fragment Complementation Assay [11]
4 Protein-peptide [17]
5 Yeast two hybrid [13]
Interacting Target Name Protein-tyrosine phosphatase 1B (PTP1B) Clinical trial Target Interacting Protein Info
UniProt ID
PTN1_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 1; PTP-1B
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Reconstituted Complex [34]
4 Yeast two hybrid [13]
Interacting Target Name M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP3_HUMAN 
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [35]
3 Protein-peptide [17]
Interacting Protein Name Tyrosine-protein phosphatase non-receptor type 12 (PTPN12) Interacting Protein Interacting Protein Info
UniProt ID
PTN12_HUMAN 
Synonyms PTP.PEST; PTPG1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [2]
3 Yeast two hybrid [13]
Interacting Protein Name Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) Interacting Protein Interacting Protein Info
UniProt ID
PTN22_HUMAN 
Synonyms LYP; LYP1; LYP2; PEP; PTPN8
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6) Patented-recorded Target Interacting Protein Info
UniProt ID
PTN6_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Yeast two hybrid [3]
Interacting Protein Name Tyrosine-protein phosphatase non-receptor type 18 (PTPN18) Interacting Protein Interacting Protein Info
UniProt ID
PTN18_HUMAN 
Synonyms BDP1; PTP.HSCF
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name AP endonuclease 1 (APEX1) Clinical trial Target Interacting Protein Info
UniProt ID
APEX1_HUMAN 
Synonyms REF-1 protein; Apurinic/apyrimidinic endonuclease/redox factor-1; APEX1; APEX nuclease; APEN; APE/ref-1; AP endonuclease 1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [36]
Interacting Protein Name Acyl-coenzyme A thioesterase 9 (ACOT9) Interacting Protein Interacting Protein Info
UniProt ID
ACOT9_HUMAN 
Synonyms ACATE2; MT.ACT48; MTACT48
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name DHM1-like protein (XRN2) Interacting Protein Interacting Protein Info
UniProt ID
XRN2_HUMAN 
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [36]
Eukaryotic initiation factors [+] 3 Eukaryotic initiation factors +
Interacting Protein Name Translation initiation factor eIF-2B subunit beta (EIF2B2) Interacting Protein Interacting Protein Info
UniProt ID
EI2BB_HUMAN 
Synonyms EIF.2Bbeta; EIF2B
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Translation initiation factor eIF-2B subunit epsilon (EIF2B5) Interacting Protein Interacting Protein Info
UniProt ID
EI2BE_HUMAN 
Synonyms CACH; CLE; EIF.2B; EIF2Bepsilon; LVWM
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Translation initiation factor eIF-2B subunit gamma (EIF2B3) Interacting Protein Interacting Protein Info
UniProt ID
EI2BG_HUMAN 
Synonyms EIF.2B; EIF2Bgamma
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Growth factors [+] 3 Growth factors +
Interacting Target Name Epidermal growth factor (EGF) Successful Target Interacting Protein Info
UniProt ID
EGF_HUMAN 
Synonyms Pro-epidermal growth factor; Proepidermal growth factor
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [37]
2 Affinity Capture-MS [6]
3 Co-crystal Structure [38]
4 Co-localization [39]
5 Reconstituted Complex [40]
Interacting Target Name Transforming growth factor alpha (TGFA) Clinical trial Target Interacting Protein Info
UniProt ID
TGFA_HUMAN 
Synonyms TGF-alpha (40-89); TGF type 1 (40-89); Protransforming growth factor alpha (40-89); ETGF (40-89); EGF-like TGF (40-89)
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [41]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Pro-neuregulin-1 (Pro-NRG1) Clinical trial Target Interacting Protein Info
UniProt ID
NRG1_HUMAN 
Synonyms SMDF (20-241); Pro-neuregulin-1, membrane-bound isoform (20-241); NDF (20-241); HRGA (20-241); HGL (20-241); Heregulin (20-241); GGF (20-241)
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Heat shock proteins [+] 6 Heat shock proteins +
Interacting Target Name Heat shock protein 90 beta (HSP90B) Clinical trial Target Interacting Protein Info
UniProt ID
HS90B_HUMAN 
Synonyms HSP84; HSP 84; Heat shock 84 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [5]
4 Protein-Fragment Complementation Assay [11]
5 Yeast two hybrid [13]
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [43]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [5]
3 Protein-Fragment Complementation Assay [2]
4 Yeast two hybrid [13]
Interacting Protein Name Heat shock 70 kDa protein 1A (HSPA1A) Interacting Protein Interacting Protein Info
UniProt ID
HS71A_HUMAN 
Synonyms HEL.S.103; HSP70.1; HSP70.1A; HSP70I; HSP72; HSPA1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [20]
3 Protein-Fragment Complementation Assay [2]
4 Yeast two hybrid [13]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [2]
3 Protein-Fragment Complementation Assay [2]
4 Yeast two hybrid [13]
Interacting Target Name Endoplasmin (HSP90B1) Clinical trial Target Interacting Protein Info
UniProt ID
ENPL_HUMAN 
Synonyms Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP-94; GRP94; gp96 homolog; 94 kDa glucose-regulated protein; 94 kDa glucoseregulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Protein-Fragment Complementation Assay [2]
Hydrolysis-driven transporters [+] 2 Hydrolysis-driven transporters +
Interacting Protein Name Calcium signal-modulating cyclophilin ligand (CAMLG) Interacting Protein Interacting Protein Info
UniProt ID
CAMLG_HUMAN 
Synonyms CAML
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) Interacting Protein Interacting Protein Info
UniProt ID
S61A1_HUMAN 
Synonyms HSEC61; SEC61; SEC61A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-Western [44]
Integrins [+] 1 Integrins +
Interacting Target Name Integrin beta-2 (ITGB2) Discontinued Target Interacting Protein Info
UniProt ID
ITB2_HUMAN 
Synonyms MFI7; Integrin alpha-M/beta-2; Complement receptor C3 subunit beta; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; CD18
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Intermediate filaments [+] 1 Intermediate filaments +
Interacting Protein Name Prelamin-A/C (LMNA) Interacting Protein Interacting Protein Info
UniProt ID
LMNA_HUMAN 
Synonyms CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; PRO1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [36]
2 Affinity Capture-Western [28]
Kinases [+] 39 Kinases +
Interacting Target Name Tyrosine-protein kinase Lyn (JTK8) Clinical trial Target Interacting Protein Info
UniProt ID
LYN_HUMAN 
Synonyms V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p56Lyn; p53Lyn; Lck/Yes-related novel protein tyrosine kinase
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [26]
3 Affinity Capture-Western [26]
4 Protein-Fragment Complementation Assay [11]
5 Yeast two hybrid [13]
Interacting Target Name Protein kinase C alpha (PRKCA) Successful Target Interacting Protein Info
UniProt ID
KPCA_HUMAN 
Synonyms Protein kinase C alpha type; Protein Kinase C alpha; PRKACA; PKC-alpha; PKCalpha; PKC-A; PKCA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [45]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Target Name B lymphocyte kinase (BLK) Patented-recorded Target Interacting Protein Info
UniProt ID
BLK_HUMAN 
Synonyms Tyrosine-protein kinase Blk; p55-Blk
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Protein-peptide [17]
4 Yeast two hybrid [13]
Interacting Target Name Tyrosine-protein kinase ZAP-70 (ZAP-70) Patented-recorded Target Interacting Protein Info
UniProt ID
ZAP70_HUMAN 
Synonyms Syk-related tyrosine kinase; SRK; 70 kDa zeta-chain associated protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Protein-peptide [17]
4 Yeast two hybrid [13]
Interacting Target Name Tyrosine-protein kinase CSK (CSK) Patented-recorded Target Interacting Protein Info
UniProt ID
CSK_HUMAN 
Synonyms Protein-tyrosine kinase CYL; C-Src kinase
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [15]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) Interacting Protein Interacting Protein Info
UniProt ID
P55G_HUMAN 
Synonyms p55; p55.GAMMA
Evidence Score (E-score) 4 Experimental Evidences +
1 Co-localization [33]
2 Protein-Fragment Complementation Assay [11]
3 Protein-peptide [17]
4 Yeast two hybrid [13]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [46]
3 Co-localization [33]
4 Protein-peptide [17]
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) Interacting Protein Interacting Protein Info
UniProt ID
P85B_HUMAN 
Synonyms MPPH; MPPH1; P85B; p85; p85.BETA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Protein-Fragment Complementation Assay [11]
3 Reconstituted Complex [47]
4 Yeast two hybrid [13]
Interacting Target Name Erbb2 tyrosine kinase receptor (HER2) Successful Target Interacting Protein Info
UniProt ID
ERBB2_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-Western [48]
3 Co-localization [49]
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Biochemical Activity [51]
3 Protein-peptide [17]
Interacting Target Name Platelet-derived growth factor receptor alpha (PDGFRA) Successful Target Interacting Protein Info
UniProt ID
PGFRA_HUMAN 
Synonyms RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGF-R-alpha; PDGFR-alpha; PDGFR-2; PDGFR2; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Proto-oncogene c-Ret (RET) Successful Target Interacting Protein Info
UniProt ID
RET_HUMAN 
Synonyms RET51; RET receptor tyrosine kinase; RET mutant Y791F; RET mutant V804M; RET mutant V804L; RET mutant S891A; RET mutant M918T; RET mutant G691S; PTC; Proto-oncogene tyrosine-protein kinase receptor Ret; C-ret; CDHR16; CDHF12; Cadherin family member 12
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Clinical trial Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Tyrosine-protein kinase ABL2 (ABL2) Literature-reported Target Interacting Protein Info
UniProt ID
ABL2_HUMAN 
Synonyms Tyrosine-protein kinase ARG; ARG; ABLL; Abelson-related gene protein; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Protein-peptide [17]
3 Yeast two hybrid [13]
Interacting Target Name Tyrosine-protein kinase Fgr (FGR) Literature-reported Target Interacting Protein Info
UniProt ID
FGR_HUMAN 
Synonyms SRC2; Proto-oncogene c-Fgr; p58-Fgr; p58c-Fgr; p55-Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Tyrosine-protein kinase FRK (FRK) Interacting Protein Interacting Protein Info
UniProt ID
FRK_HUMAN 
Synonyms GTK; PTK5; RAK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Phosphoinositide 3-kinase-C2-beta (PIK3C2B) Interacting Protein Interacting Protein Info
UniProt ID
P3C2B_HUMAN 
Synonyms C2.PI3K
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target Interacting Protein Info
UniProt ID
ABL1_HUMAN 
Synonyms Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; p150; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Erbb4 tyrosine kinase receptor (Erbb-4) Successful Target Interacting Protein Info
UniProt ID
ERBB4_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; P180erbB4; HER4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Fluorescence Resonance Energy Transfer [54]
Interacting Target Name Protein kinase C epsilon (PRKCE) Successful Target Interacting Protein Info
UniProt ID
KPCE_HUMAN 
Synonyms Protein kinase C epsilon type; Protein Kinase C epsilon; PKCE; PKC epsilon; NPKC-epsilon
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name BDNF/NT-3 growth factors receptor (TrkB) Successful Target Interacting Protein Info
UniProt ID
NTRK2_HUMAN 
Synonyms Tropomyosin-related kinase B; TrkB tyrosine kinase; Trk-B; TRKB; Neurotrophic tyrosine kinase receptor type 2; GP145-TrkB
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Erbb3 tyrosine kinase receptor (Erbb-3) Clinical trial Target Interacting Protein Info
UniProt ID
ERBB3_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB-3 protein; C-erbB3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-Western [55]
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Interacting Protein Info
UniProt ID
PIM1_HUMAN 
Synonyms PIM; Pim-1 proto-oncogene, serine/threonine kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name T-cell-specific kinase (ITK) Clinical trial Target Interacting Protein Info
UniProt ID
ITK_HUMAN 
Synonyms Tyrosine-protein kinase Lyk; Tyrosine-protein kinase ITK/TSK; Tyrosine kinase ITK; LYK; Kinase EMT; Interleukin-2-inducible T-cell kinase; Inducible T cell kinase; IL-2-inducible T-cell kinase; EMT
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Tyrosine-protein kinase BRK (PTK6) Clinical trial Target Interacting Protein Info
UniProt ID
PTK6_HUMAN 
Synonyms Tyrosine-protein kinase brk; PTK6; Brk (PTK6); BRK; Breast tumor kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [56]
2 Protein-peptide [17]
Interacting Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target Interacting Protein Info
UniProt ID
RAF1_HUMAN 
Synonyms Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Stress-activated protein kinase JNK2 (JNK2) Patented-recorded Target Interacting Protein Info
UniProt ID
MK09_HUMAN 
Synonyms Stress-activated protein kinase 1a; SAPK1a; PRKM9; Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 8-interacting protein 2; MAPK 9; MAP kinase 9; Jun-N-terminal kinase 2; JNK-interacting protein 2; JNK-55; JNK MAP kinase scaffold protein 2; JIP-2; Islet-brain-2; IB-2; C-jun-amino-terminal kinase interacting protein 2; C-Jun N-terminal kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Protein kinase C zeta (PRKCZ) Patented-recorded Target Interacting Protein Info
UniProt ID
KPCZ_HUMAN 
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Activated CDC42 kinase 1 (ACK-1) Patented-recorded Target Interacting Protein Info
UniProt ID
ACK1_HUMAN 
Synonyms Tyrosine kinase non-receptor protein 2; Tyrosine kinase nonreceptor protein 2; ACK-1; ACK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [57]
Interacting Target Name MAPK/ERK kinase kinase 3 (MAP3K3) Literature-reported Target Interacting Protein Info
UniProt ID
M3K3_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MEK kinase 3; MAPKKK3
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Hematopoietic cell kinase (HCK) Patented-recorded Target Interacting Protein Info
UniProt ID
HCK_HUMAN 
Synonyms Tyrosine-protein kinase HCK; p61Hck; p59-HCK/p60-HCK; p59Hck; Hemopoietic cell kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name MEK kinase kinase 1 (MAP4K1) Literature-reported Target Interacting Protein Info
UniProt ID
M4K1_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase kinase 1; MEKKK 1; MAPK/ERK kinase kinase kinase 1; HPK1; Hematopoietic progenitor kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name PAK-1 protein kinase (PAK1) Literature-reported Target Interacting Protein Info
UniProt ID
PAK1_HUMAN 
Synonyms Serine/threonine-protein kinase PAK 1; PAK-1; p65-PAK; p21-activated kinase 1; Alpha-PAK
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Phosphofructo-1-kinase isozyme B (PFKL) Interacting Protein Interacting Protein Info
UniProt ID
PFKAL_HUMAN 
Synonyms ATP.PFK; PFK.B; PFK.L
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Phosphofructo-1-kinase isozyme C (PFKP) Interacting Protein Interacting Protein Info
UniProt ID
PFKAP_HUMAN 
Synonyms ATP.PFK; PFK.C; PFK.P; PFKF
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Ligases [+] 1 Ligases +
Interacting Target Name Isoleucyl-tRNA synthetase (IARS) Literature-reported Target Interacting Protein Info
UniProt ID
SYIC_HUMAN 
Synonyms Isoleucine--tRNA ligase, cytoplasmic; Isoleucine--tRNA ligase; IRS; IleRS
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Lyases [+] 1 Lyases +
Interacting Target Name Sphingosine-1-phosphate lyase 1 (SGPL1) Clinical trial Target Interacting Protein Info
UniProt ID
SGPL1_HUMAN 
Synonyms SP-lyase 1; SPL 1; Sphingosine-1-phosphate lyase 1; Sphingosine-1-phosphate aldolase; S1PL; KIAA1252; hSPL
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [20]
Membrane-bounded channels [+] 5 Membrane-bounded channels +
Interacting Target Name Importin beta (KPNB1) Literature-reported Target Interacting Protein Info
UniProt ID
IMB1_HUMAN 
Synonyms PTAC97; Pore targeting complex 97 kDa subunit; Nuclear factor p97; NTF97; Karyopherin subunit beta-1; Karyopherin subunit beta1; Importin-90; Importin90; Importin subunit beta-1; Importin subunit beta1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Importin-11 (IPO11) Interacting Protein Interacting Protein Info
UniProt ID
IPO11_HUMAN 
Synonyms RanBP11
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Nuclear pore complex protein Nup93 (NUP93) Interacting Protein Interacting Protein Info
UniProt ID
NUP93_HUMAN 
Synonyms NIC96
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Exportin-7 (XPO7) Interacting Protein Interacting Protein Info
UniProt ID
XPO7_HUMAN 
Synonyms EXP7; RANBP16
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Exportin-T (XPOT) Interacting Protein Interacting Protein Info
UniProt ID
XPOT_HUMAN 
Synonyms XPO3
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Microtubule-associated protein tau (MAPT) Clinical trial Target Interacting Protein Info
UniProt ID
TAU_HUMAN 
Synonyms tau; TAU; Paired helical filament-tau; Paired helical filamenttau; Neurofibrillary tangle protein; MTBT1; Microtubule-associated protein tau; MAPTL
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Nuclear hormone receptors [+] 2 Nuclear hormone receptors +
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [58]
Oxidoreductases [+] 2 Oxidoreductases +
Interacting Target Name Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Clinical trial Target Interacting Protein Info
UniProt ID
G3P_HUMAN 
Synonyms Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-Western [26]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Peroxiredoxin-1 (PRDX1) Interacting Protein Interacting Protein Info
UniProt ID
PRDX1_HUMAN 
Synonyms MSP23; NKEF.A; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Protein-Fragment Complementation Assay [2]
Peptidases [+] 1 Peptidases +
Interacting Target Name Ubiquitin isopeptidase Y (USP8) Literature-reported Target Interacting Protein Info
UniProt ID
UBP8_HUMAN 
Synonyms UBPY; Ubiquitin-specific-processing protease 8; Ubiquitin thioesterase 8; Ubiquitin carboxyl-terminal hydrolase 8; KIAA0055; hUBPy; Deubiquitinating enzyme 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [59]
2 Biochemical Activity [60]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Amyloid beta A4 protein (APP) Successful Target Interacting Protein Info
UniProt ID
A4_HUMAN 
Synonyms Vascular beta-amyloid; Protease nexin-II; PreA4; PN-II; CVAP; Cerebral vascular amyloidpeptide; Cerebral vascular amyloid peptide; Beta-amyloid peptide; APPI; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Amyloid precursor protein; Amyloid beta precursor protein; Alzheimer's disease amyloid protein; Alzheimer disease amyloid protein; AD1; ABPP; A4
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Proteins 14-3-3 [+] 3 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein sigma (SFN) Interacting Protein Interacting Protein Info
UniProt ID
1433S_HUMAN 
Synonyms YWHAS
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-Western [26]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Putative transporters [+] 8 Putative transporters +
Interacting Target Name LDL receptor related protein-1 (LRP-1) Literature-reported Target Interacting Protein Info
UniProt ID
LRP1_HUMAN 
Synonyms Prolow-density lipoprotein receptor-related protein 1; CD91; APR; Apolipoprotein E receptor; APOER; Alpha-2-macroglobulin receptor; A2MR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name AP-2 complex subunit alpha-1 (AP2A1) Interacting Protein Interacting Protein Info
UniProt ID
AP2A1_HUMAN 
Synonyms ADTAA; AP2.ALPHA; CLAPA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-Western [30]
Interacting Protein Name AP-2 complex subunit mu (AP2M1) Interacting Protein Interacting Protein Info
UniProt ID
AP2M1_HUMAN 
Synonyms AP50; CLAPM1; mu2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Protein-Fragment Complementation Assay [2]
Interacting Protein Name AP-1 complex subunit gamma-1 (AP1G1) Interacting Protein Interacting Protein Info
UniProt ID
AP1G1_HUMAN 
Synonyms ADTG; CLAPG1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name AP-1 complex subunit mu-1 (AP1M1) Interacting Protein Interacting Protein Info
UniProt ID
AP1M1_HUMAN 
Synonyms AP47; CLAPM2; CLTNM; MU.1A
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name AP-1 complex subunit sigma-1A (AP1S1) Interacting Protein Interacting Protein Info
UniProt ID
AP1S1_HUMAN 
Synonyms AP19; CLAPS1; EKV3; MEDNIK; SIGMA1A
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name AP-2 complex subunit alpha-2 (AP2A2) Interacting Protein Interacting Protein Info
UniProt ID
AP2A2_HUMAN 
Synonyms ADTAB; CLAPA2; HIP.9; HIP9; HYPJ
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [20]
Interacting Protein Name AP-2 complex subunit beta (AP2B1) Interacting Protein Interacting Protein Info
UniProt ID
AP2B1_HUMAN 
Synonyms ADTB2; AP105B; AP2.BETA; CLAPB1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [20]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [61]
3 Biochemical Activity [62]
4 Co-localization [63]
5 Protein-Fragment Complementation Assay [11]
6 Yeast two hybrid [13]
Interacting Protein Name Signal transducer and activator of transcription 5A (STA5A) Interacting Protein Interacting Protein Info
UniProt ID
STA5A_HUMAN 
Synonyms MGF; STAT5
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [15]
3 Biochemical Activity [62]
4 Co-localization [39]
5 Protein-Fragment Complementation Assay [11]
6 Yeast two hybrid [13]
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [50]
4 Protein-Fragment Complementation Assay [11]
5 Yeast two hybrid [13]
Interacting Protein Name Signal transducer and activator of transcription 5B (STA5B) Interacting Protein Interacting Protein Info
UniProt ID
STA5B_HUMAN 
Synonyms STAT5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [64]
2 Co-localization [39]
Interacting Protein Name Signal transducer and activator of transcription 2 (STAT2) Interacting Protein Interacting Protein Info
UniProt ID
STAT2_HUMAN 
Synonyms ISGF.3; P113; STAT113
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Translocases [+] 3 Translocases +
Interacting Target Name Sodium pump subunit alpha-1 (ATP1A1) Successful Target Interacting Protein Info
UniProt ID
AT1A1_HUMAN 
Synonyms Sodium/potassium-transporting ATPase alpha1; Sodium pump 1; Na+/K+ ATPase 1; ATP1A1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [3]
Interacting Target Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) Clinical trial Target Interacting Protein Info
UniProt ID
AT2A2_HUMAN 
Synonyms SR Ca(2+)Sarcoplasmic/endoplasmic reticulum calcium ATPase 2-ATPase 2; SR Ca(2+)-ATPase 2; SR Ca(2+)-ATPase; SR Ca(2+) pump; SERCA2; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Cardiacsarcoplasmic reticulum calcium ATPase; CardiacCa2+ ATPase (SERCA2a); Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Calciumpump 2; Calcium pump 2; ATP2B
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [20]
Interacting Protein Name Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) Interacting Protein Interacting Protein Info
UniProt ID
TIM50_HUMAN 
Synonyms TIM50; TIM50L
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Ubiquitin related proteins [+] 3 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [65]
Interacting Target Name E3 ubiquitin protein ligase CBLB (CBLB) Literature-reported Target Interacting Protein Info
UniProt ID
CBLB_HUMAN 
Synonyms Signal transduction protein CBL-B; Signal transduction protein CBLB; SH3-binding protein CBL-B; SH3binding protein CBLB; RNF56; RING-type E3 ubiquitin transferase CBL-B; RING finger protein 56; Nbla00127; E3 ubiquitin-protein ligase CBL-B; E3 ubiquitinprotein ligase CBLB; Casitas B-lineage lymphoma proto-oncogene b; Casitas Blineage lymphoma protooncogene b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [66]
Interacting Protein Name Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) Interacting Protein Interacting Protein Info
UniProt ID
UBS3B_HUMAN 
Synonyms STS.1; STS1; TULA.2; TULA2; p70
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [20]
Other proteins [+] 73 Other proteins +
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [67]
3 Biochemical Activity [68]
4 Protein-Fragment Complementation Assay [11]
5 Protein-peptide [17]
6 Yeast two hybrid [13]
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [15]
3 Affinity Capture-Western [69]
4 Protein-Fragment Complementation Assay [11]
5 Protein-peptide [17]
6 Yeast two hybrid [13]
Interacting Target Name Mucin-1 (MUC1) Clinical trial Target Interacting Protein Info
UniProt ID
MUC1_HUMAN 
Synonyms Tumour-associated antigen mucin 1; Tumor-associated mucin; Tumor-associated epithelial membraneantigen; Tumor-associated epithelial membrane antigen; PUM; Polymorphic epithelial mucin; PEMT; PEM; Peanut-reactive urinary mucin; Mucin-1; MUC-1; Krebs von den Lungen-6; KL-6; H23AG; Episialin; EMA; CD227 antigen; CD227; Carcinoma-associated mucin; Cancer antigen 15-3; CA 15-3; Breast carcinoma-associated antigen DF3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [70]
3 Biochemical Activity [71]
4 Protein-Fragment Complementation Assay [11]
5 Yeast two hybrid [13]
Interacting Protein Name Calmodulin-1 (CALM1) Interacting Protein Interacting Protein Info
UniProt ID
CALM1_HUMAN 
Synonyms CALML2; CAMI; CPVT4; DD132; PHKD; caM
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Affinity Capture-Western [72]
3 Protein-Fragment Complementation Assay [11]
4 Reconstituted Complex [73]
5 Yeast two hybrid [13]
Interacting Protein Name Catenin delta-1 (CTNND1) Interacting Protein Interacting Protein Info
UniProt ID
CTND1_HUMAN 
Synonyms CAS; CTNND; P120CAS; P120CTN; p120; p120(CAS); p120(CTN)
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [20]
3 Protein-Fragment Complementation Assay [11]
4 Reconstituted Complex [74]
5 Yeast two hybrid [13]
Interacting Protein Name SHC-transforming protein 4 (SHC4) Interacting Protein Interacting Protein Info
UniProt ID
SHC4_HUMAN 
Synonyms RaLP; SHCD
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [75]
3 Co-localization [75]
4 Protein-Fragment Complementation Assay [11]
5 Yeast two hybrid [13]
Interacting Target Name Junction plakoglobin (JUP) Literature-reported Target Interacting Protein Info
UniProt ID
PLAK_HUMAN 
Synonyms Plakoglobin; DP3; Desmoplakin-3; Desmoplakin III; CTNNG; Catenin gamma
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-Fragment Complementation Assay [11]
3 Reconstituted Complex [74]
4 Yeast two hybrid [13]
Interacting Target Name Epithelial cadherin (CDH1) Literature-reported Target Interacting Protein Info
UniProt ID
CADH1_HUMAN 
Synonyms Uvomorulin; UVO; E-cadherin gene; E-cadherin; CDHE; CD324; CAM 120/80; Cadherin-1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Co-localization [33]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Target Name Suppressor of cytokine signaling 3 (SOCS3) Literature-reported Target Interacting Protein Info
UniProt ID
SOCS3_HUMAN 
Synonyms STAT-induced STAT inhibitor 3; STAT induced STAT inhibitor 3; SSI-3; SSI3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; CIS3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [76]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) Interacting Protein Interacting Protein Info
UniProt ID
ANS1A_HUMAN 
Synonyms ANKS1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Protein-peptide [17]
4 Yeast two hybrid [13]
Interacting Protein Name Amyloid-beta A4 precursor protein-binding family B member 2 (APBB2) Interacting Protein Interacting Protein Info
UniProt ID
APBB2_HUMAN 
Synonyms FE65L; FE65L1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Protein-peptide [17]
4 Yeast two hybrid [13]
Interacting Protein Name Cytokine-inducible SH2-containing protein (CISH) Interacting Protein Interacting Protein Info
UniProt ID
CISH_HUMAN 
Synonyms BACTS2; CIS; CIS.1; G18; SOCS
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Protein-peptide [17]
4 Yeast two hybrid [13]
Interacting Protein Name Crk-like protein (CRKL) Interacting Protein Interacting Protein Info
UniProt ID
CRKL_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [14]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Epidermal growth factor receptor kinase substrate 8 (EPS8) Interacting Protein Interacting Protein Info
UniProt ID
EPS8_HUMAN 
Synonyms DFNB102
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [77]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name ERBB receptor feedback inhibitor 1 (ERRFI1) Interacting Protein Interacting Protein Info
UniProt ID
ERRFI_HUMAN 
Synonyms GENE.33; MIG.6; MIG6; RALT
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [78]
3 Biochemical Activity [78]
4 Co-crystal Structure [78]
Interacting Protein Name Programmed cell death 6-interacting protein (PDCD6IP) Interacting Protein Interacting Protein Info
UniProt ID
PDC6I_HUMAN 
Synonyms AIP1; ALIX; DRIP4; HP95
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [79]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name SH2 domain-containing protein 3A (SH2D3A) Interacting Protein Interacting Protein Info
UniProt ID
SH23A_HUMAN 
Synonyms NSP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [80]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Endophilin-A1 (SH3GL2) Interacting Protein Interacting Protein Info
UniProt ID
SH3G2_HUMAN 
Synonyms CNSA2; EEN.B1; SH3D2A; SH3P4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [79]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Src substrate cortactin (CTTN) Interacting Protein Interacting Protein Info
UniProt ID
SRC8_HUMAN 
Synonyms EMS1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [1]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Protein Name Tubulin alpha-1A chain (TUBA1A) Interacting Protein Interacting Protein Info
UniProt ID
TBA1A_HUMAN 
Synonyms B.ALPHA.1; LIS3; TUBA3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-MS [26]
3 Protein-Fragment Complementation Assay [11]
4 Yeast two hybrid [13]
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Affinity Capture-Western [81]
3 Reconstituted Complex [74]
Interacting Target Name Synuclein alpha (SNCA) Clinical trial Target Interacting Protein Info
UniProt ID
SYUA_HUMAN 
Synonyms PARK1; Non-A4 component of amyloid precursor; NonA4 component of amyloid precursor; Non-A beta component of AD amyloid; NonA beta component of AD amyloid; NACP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Beta-arrestin-1 (ARRB1) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB1_HUMAN 
Synonyms Non-visual arrestin-2; Betaarrestin1; Arrestin beta-1; Arrestin beta1; ARR1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Target Name Regulator of G-protein signaling 4 (RGS4) Literature-reported Target Interacting Protein Info
UniProt ID
RGS4_HUMAN 
Synonyms RGP4
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [82]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Docking protein 1 (DOK1) Interacting Protein Interacting Protein Info
UniProt ID
DOK1_HUMAN 
Synonyms P62DOK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2) Interacting Protein Interacting Protein Info
UniProt ID
JIP2_HUMAN 
Synonyms IB.2; IB2; JIP2; PRKM8IPL
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Protein-peptide [17]
3 Yeast two hybrid [13]
Interacting Protein Name Linker for activation of T-cells family member 1 (LAT) Interacting Protein Interacting Protein Info
UniProt ID
LAT_HUMAN 
Synonyms LAT1; pp36
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Lymphocyte cytosolic protein 2 (LCP2) Interacting Protein Interacting Protein Info
UniProt ID
LCP2_HUMAN 
Synonyms SLP.76; SLP76
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Rap guanine nucleotide exchange factor 1 (RAPGEF1) Interacting Protein Interacting Protein Info
UniProt ID
RPGF1_HUMAN 
Synonyms C3G; GRF2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Son of sevenless homolog 1 (SOS1) Interacting Protein Interacting Protein Info
UniProt ID
SOS1_HUMAN 
Synonyms GF1; GGF1; GINGF; HGF; NS4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [83]
3 Reconstituted Complex [84]
Interacting Protein Name Son of sevenless homolog 2 (SOS2) Interacting Protein Interacting Protein Info
UniProt ID
SOS2_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) Interacting Protein Interacting Protein Info
UniProt ID
TAB1_HUMAN 
Synonyms 3.Tab1; MAP3K7IP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Tensin-3 (TNS3) Interacting Protein Interacting Protein Info
UniProt ID
TENS3_HUMAN 
Synonyms TEM6; TENS1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Protein-Fragment Complementation Assay [11]
3 Yeast two hybrid [13]
Interacting Protein Name Proto-oncogene vav (VAV1) Interacting Protein Interacting Protein Info
UniProt ID
VAV_HUMAN 
Synonyms VAV
Evidence Score (E-score) 3 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Protein-peptide [17]
3 Yeast two hybrid [13]
Interacting Target Name Tumor necrosis factor receptor type I (TNF-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TNR1A_HUMAN 
Synonyms Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-RI; TNFR-I; TNFR1; TNFAR; TBPI; p60; p55; CD120a
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Galectin-3 (LGALS3) Clinical trial Target Interacting Protein Info
UniProt ID
LEG3_HUMAN 
Synonyms Mac-2 antigen; MAC2; Lectin L-29; Laminin-binding protein; L-31; IgE-binding protein; GALBP; Galactoside-binding protein; Galactose-specific lectin 3; Gal-3; CBP 35; Carbohydrate-binding protein 35; Carbohydrate binding protein 35; Beta-galactoside-binding protein LGALS3; 35 kDa lectin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-Western [85]
Interacting Target Name Beta-arrestin-2 (ARRB2) Literature-reported Target Interacting Protein Info
UniProt ID
ARRB2_HUMAN 
Synonyms Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Vascular endothelial cadherin (CDH5) Literature-reported Target Interacting Protein Info
UniProt ID
CADH5_HUMAN 
Synonyms VE-cadherin; VE-cad; CD144 antigen; CD144; Cadherin-5; 7B4 antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Galectin-1 (LGALS1) Patented-recorded Target Interacting Protein Info
UniProt ID
LEG1_HUMAN 
Synonyms S-Lac lectin 1; SLac lectin 1; Putative MAPK-activating protein PM12; Putative MAPKactivating protein PM12; Lectin galactoside-binding soluble 1; Lectin galactosidebinding soluble 1; Lactose-binding lectin 1; Lactosebinding lectin 1; HPL; HLBP14; HBL; Galaptin; Gal-1; Gal1; Beta-galactoside-binding lectin L-14-I; Betagalactosidebinding lectin L14I; 14 kDa lectin; 14 kDa laminin-binding protein; 14 kDa lamininbinding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-Western [85]
Interacting Target Name GTPase activating protein (RASA1) Literature-reported Target Interacting Protein Info
UniProt ID
RASA1_HUMAN 
Synonyms RasGAP; RASA; Ras p21 protein activator; Ras GTPase-activating protein 1; p120GAP; GTPase-activating protein; GAP
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [17]
2 Reconstituted Complex [86]
Interacting Target Name Decorin (DCN) Literature-reported Target Interacting Protein Info
UniProt ID
PGS2_HUMAN 
Synonyms SLRR1B; PG-S2; PGS2; PG40; Bone proteoglycan II
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [87]
2 Yeast two hybrid [87]
Interacting Protein Name Neuroblast differentiation-associated protein AHNAK (AHNAK) Interacting Protein Interacting Protein Info
UniProt ID
AHNK_HUMAN 
Synonyms AHNAKRS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Protein-Fragment Complementation Assay [2]
Interacting Protein Name Ankyrin repeat domain-containing protein 13A (ANKRD13A) Interacting Protein Interacting Protein Info
UniProt ID
AN13A_HUMAN 
Synonyms ANKRD13; NY.REN.25
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Affinity Capture-Western [88]
Interacting Protein Name Rho guanine nucleotide exchange factor 7 (ARHGEF7) Interacting Protein Interacting Protein Info
UniProt ID
ARHG7_HUMAN 
Synonyms BETA.PIX; COOL.1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Catenin alpha-1 (CTNNA1) Interacting Protein Interacting Protein Info
UniProt ID
CTNA1_HUMAN 
Synonyms CAP102
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Co-localization [33]
Interacting Protein Name Elongation factor 1-gamma (EEF1G) Interacting Protein Interacting Protein Info
UniProt ID
EF1G_HUMAN 
Synonyms EF1G; GIG35
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Protein-Fragment Complementation Assay [2]
Interacting Protein Name Emerin (EMD) Interacting Protein Interacting Protein Info
UniProt ID
EMD_HUMAN 
Synonyms EDMD; LEMD5; STA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-fractionation [44]
Interacting Protein Name Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) Interacting Protein Interacting Protein Info
UniProt ID
HGS_HUMAN 
Synonyms HRS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [89]
2 Reconstituted Complex [23]
Interacting Protein Name SH2 domain-containing protein 3C (SH2D3C) Interacting Protein Interacting Protein Info
UniProt ID
SH2D3_HUMAN 
Synonyms CHAT; NSP3; PRO34088; SHEP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Endophilin-A3 (SH3GL3) Interacting Protein Interacting Protein Info
UniProt ID
SH3G3_HUMAN 
Synonyms CNSA3; EEN.B2; HsT19371; SH3D2C; SH3P13
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Sorting nexin-9 (SNX9) Interacting Protein Interacting Protein Info
UniProt ID
SNX9_HUMAN 
Synonyms SDP1; SH3PX1; SH3PXD3A; WISP
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Suppressor of cytokine signaling 6 (SOCS6) Interacting Protein Interacting Protein Info
UniProt ID
SOCS6_HUMAN 
Synonyms CIS.4; CIS4; HSPC060; SOCS.4; SOCS.6; SOCS4; SSI4; STAI4; STATI4
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Vesicle-associated membrane protein-associated protein A (VAPA) Interacting Protein Interacting Protein Info
UniProt ID
VAPA_HUMAN 
Synonyms VAP.33; VAP.A; VAP33; hVAP.33
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [30]
2 Protein-Fragment Complementation Assay [2]
Interacting Protein Name Guanine nucleotide exchange factor VAV2 (VAV2) Interacting Protein Interacting Protein Info
UniProt ID
VAV2_HUMAN 
Synonyms VAV.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [90]
Interacting Protein Name Wiskott-Aldrich syndrome protein family member 3 (WASF3) Interacting Protein Interacting Protein Info
UniProt ID
WASF3_HUMAN 
Synonyms Brush.1; SCAR3; WAVE3
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Protein Name Neural Wiskott-Aldrich syndrome protein (WASL) Interacting Protein Interacting Protein Info
UniProt ID
WASL_HUMAN 
Synonyms N.WASP; NWASP
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [11]
2 Yeast two hybrid [13]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [36]
Interacting Target Name Nucleolin (NCL) Clinical trial Target Interacting Protein Info
UniProt ID
NUCL_HUMAN 
Synonyms Protein C23; Nucleolin
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [36]
Interacting Target Name Exportin-2 (CSE1L) Literature-reported Target Interacting Protein Info
UniProt ID
XPO2_HUMAN 
Synonyms Importin-alpha re-exporter; Exp2; CSE1L; Chromosome segregation 1-like protein; Cellular apoptosis susceptibility protein
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [3]
Interacting Protein Name Armadillo repeat-containing protein 8 (ARMC8) Interacting Protein Interacting Protein Info
UniProt ID
ARMC8_HUMAN 
Synonyms GID5; HSPC056; VID28
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [20]
Interacting Protein Name Dynein assembly factor 5 (DNAAF5) Interacting Protein Interacting Protein Info
UniProt ID
DAAF5_HUMAN 
Synonyms CILD18; HEATR2
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name DnaJ homolog subfamily A member 1 (DNAJA1) Interacting Protein Interacting Protein Info
UniProt ID
DNJA1_HUMAN 
Synonyms DJ.2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ.2
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name DnaJ homolog subfamily A member 2 (DNAJA2) Interacting Protein Interacting Protein Info
UniProt ID
DNJA2_HUMAN 
Synonyms CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Hepatocellular carcinoma-associated antigen 57 (DNAJA3) Interacting Protein Interacting Protein Info
UniProt ID
DNJA3_HUMAN 
Synonyms HCA57; TID1; hTID.1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name BFA-resistant GEF 1 (GBF1) Interacting Protein Interacting Protein Info
UniProt ID
GBF1_HUMAN 
Synonyms ARF1GEF
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [3]
Interacting Protein Name Immunoglobulin kappa variable 1D-16 (IGKV1D-16) Interacting Protein Interacting Protein Info
UniProt ID
KVD16_HUMAN 
Synonyms HCAK1; IGKCD; Km
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [3]
Interacting Protein Name MMS19 nucleotide excision repair protein homolog (MMS19) Interacting Protein Interacting Protein Info
UniProt ID
MMS19_HUMAN 
Synonyms MET18; MMS19L; hMMS19
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Pleckstrin homology-like domain family A member 1 (PHLDA1) Interacting Protein Interacting Protein Info
UniProt ID
PHLA1_HUMAN 
Synonyms DT1P1B11; PHRIP; TDAG51
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [20]
Interacting Protein Name Ribophorin I (RPN1) Interacting Protein Interacting Protein Info
UniProt ID
RPN1_HUMAN 
Synonyms OST1; RBPH1
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Tubulin beta-6 chain (TUBB6) Interacting Protein Interacting Protein Info
UniProt ID
TBB6_HUMAN 
Synonyms HsT1601; TUBB.5
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name Transportin-3 (TNPO3) Interacting Protein Interacting Protein Info
UniProt ID
TNPO3_HUMAN 
Synonyms IPO12; LGMD1F; MTR10A; TRN.SR; TRN.SR2; TRNSR
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Interacting Protein Name V-type proton ATPase subunit H (ATP6V1H) Interacting Protein Interacting Protein Info
UniProt ID
VATH_HUMAN 
Synonyms MSTP042; NBP1; SFD; SFDalpha; SFDbeta; VMA13
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
References
REF 1 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics. 2014 Jul;13(7):1644-58.
REF 2 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal. 2009 Dec 22;2(102):ra84.
REF 3 A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360.
REF 4 RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma. Mol Cancer Ther. 2014 Dec;13(12):3049-61.
REF 5 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem. 2003 Feb 14;278(7):5292-9.
REF 6 Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics. 2009 Sep;8(9):2131-44.
REF 7 Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell. 2003 Sep 19;114(6):715-25.
REF 8 Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates. EMBO J. 2008 Mar 5;27(5):804-16.
REF 9 c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes. J Biol Chem. 2004 Aug 27;279(35):37153-62.
REF 10 Threshold-controlled ubiquitination of the EGFR directs receptor fate. EMBO J. 2013 Jul 31;32(15):2140-57.
REF 11 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 12 CHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFR. Oncotarget. 2014 Apr 15;5(7):1969-86.
REF 13 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 14 Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. J Proteome Res. 2008 Mar;7(3):1067-77.
REF 15 Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1:2005.0008.
REF 16 The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor. Oncogene. 1997 Feb 27;14(8):923-8.
REF 17 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 18 Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression. Cell Growth Differ. 2001 Jun;12(6):307-18.
REF 19 Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. Biochemistry. 1999 Jan 5;38(1):151-9.
REF 20 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol Syst Biol. 2013 Nov 5;9:705.
REF 21 STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization. J Biol Chem. 2017 Nov 24;292(47):19392-19399.
REF 22 Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. J Biol Chem. 2007 May 18;282(20):15294-301.
REF 23 A role for Hrs in endosomal sorting of ligand-stimulated and unstimulated epidermal growth factor receptor. Exp Cell Res. 2004 Jul 15;297(2):380-91.
REF 24 Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor. J Biol Chem. 2009 Jun 19;284(25):16979-89.
REF 25 Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells. J Biol Chem. 2015 Dec 25;290(52):30866-78.
REF 26 Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation ... Mol Cell Proteomics. 2006 Sep;5(9):1610-27.
REF 27 Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J Biol Chem. 1997 Nov 28;272(48):30429-38.
REF 28 Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production. Radiother Oncol. 2015 Sep;116(3):431-7.
REF 29 The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem. 2010 Apr 9;285(15):11219-26.
REF 30 Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. Proteomics. 2013 Nov;13(21):3131-44.
REF 31 Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C. J Biol Chem. 1995 Sep 8;270(36):21277-84.
REF 32 Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584. Cell Growth Differ. 1996 Dec;7(12):1589-97.
REF 33 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 34 Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B. J Biol Chem. 1993 Nov 5;268(31):23634-9.
REF 35 EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells. Am J Physiol Renal Physiol. 2009 Sep;297(3):F822-34.
REF 36 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin Cancer Res. 2014 Jul 1;20(13):3496-506.
REF 37 LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity. Hum Mol Genet. 2014 Dec 20;23(25):6779-96.
REF 38 Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell. 2002 Sep 20;110(6):775-87.
REF 39 Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter. Int J Cancer. 2013 Feb 1;132(3):509-20.
REF 40 A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. J Biol Chem. 1999 Mar 26;274(13):8900-9.
REF 41 Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell. 2002 Sep 20;110(6):763-73.
REF 42 Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases. J Biol Chem. 1995 Apr 28;270(17):9982-90.
REF 43 Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy. EMBO J. 2002 May 15;21(10):2407-17.
REF 44 The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem. 2010 Dec 3;285(49):38720-9.
REF 45 Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor. Biochem Biophys Res Commun. 2003 Aug 8;307(4):839-46.
REF 46 Transforming growth factor--induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway. Int J Oncol. 2011 Oct;39(4):1001-9.
REF 47 Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system. Biochem J. 1992 Dec 1;288 ( Pt 2):395-405.
REF 48 The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane. Mol Biol Cell. 2005 Dec;16(12):5832-42.
REF 49 HER2 signaling regulates HER2 localization and membrane retention. PLoS One. 2017 Apr 3;12(4):e0174849.
REF 50 ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem. 1999 Jun 11;274(24):17209-18.
REF 51 Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 9;6(283):ra55.
REF 52 EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression. Oncotarget. 2017 Apr 18;8(16):27155-27165.
REF 53 Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src). J Biol Chem. 2000 Apr 28;275(17):12619-25.
REF 54 The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility. Sci Signal. 2014 Aug 19;7(339):ra78.
REF 55 Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain. Glia. 2009 Mar;57(4):362-79.
REF 56 Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. J Biol Chem. 1996 Nov 29;271(48):30956-63.
REF 57 HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol. 2010 Mar;30(6):1541-54.
REF 58 Epidermal growth factor directs sex-specific steroid signaling through Src activation. J Biol Chem. 2007 Apr 6;282(14):10697-706.
REF 59 Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells by Inducing Apoptosis. J Cancer Prev. 2015 Mar;20(1):57-63.
REF 60 Mutations in the deubiquitinase gene USP8 cause Cushing's disease. Nat Genet. 2015 Jan;47(1):31-8.
REF 61 Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol. 2004 Nov;24(21):9390-400.
REF 62 EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14;24(4):438-49.
REF 63 Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005 Jun;7(6):575-89.
REF 64 STAT 1alpha/1beta, STAT 3 and STAT 5: expression and association with c-MET and EGF-receptor in long-term cultures of human hepatocytes. Biochem Biophys Res Commun. 1999 Nov 19;265(2):376-81.
REF 65 Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol. 2002 Apr 1;157(1):91-101.
REF 66 EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. Oncogene. 2006 Oct 19;25(49):6497-509.
REF 67 Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta. Cell Signal. 1998 Apr;10(4):283-90.
REF 68 Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor. J Biol Chem. 1998 Jul 3;273(27):17186-91.
REF 69 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell. 1999 Dec;4(6):1029-40.
REF 70 MUC1 is a novel regulator of ErbB1 receptor trafficking. Oncogene. 2007 Mar 15;26(12):1693-701.
REF 71 The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 2001 Sep 21;276(38):35239-42.
REF 72 Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells. FEBS Lett. 2004 Feb 13;559(1-3):175-80.
REF 73 Interactions between the juxtamembrane domain of the EGFR and calmodulin measured by surface plasmon resonance. Cell Signal. 2002 Dec;14(12):1005-13.
REF 74 The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J Biol Chem. 1998 Apr 10;273(15):9078-84.
REF 75 The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking. J Cell Sci. 2017 Sep 1;130(17):2808-2820.
REF 76 Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J Biol Chem. 2002 Aug 23;277(34):30716-23.
REF 77 Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell. 2001 Jun;12(6):1897-910.
REF 78 Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat Struct Mol Biol. 2015 Sep;22(9):703-711.
REF 79 Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol. 2004 Oct;24(20):8981-93.
REF 80 NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J Biol Chem. 1999 Apr 9;274(15):10047-52.
REF 81 ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas. J Biol Chem. 2002 Jun 21;277(25):22692-8.
REF 82 RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation. J Biol Chem. 2001 Dec 21;276(51):48532-8.
REF 83 SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration. Oncogene. 2010 Jul 22;29(29):4130-44.
REF 84 A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J Biol Chem. 1994 Mar 25;269(12):9019-23.
REF 85 Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis. Glycobiology. 2009 May;19(5):547-59.
REF 86 Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J Biol Chem. 1996 May 24;271(21):12502-10.
REF 87 Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. J Biol Chem. 2002 Sep 20;277(38):35671-81.
REF 88 The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Mol Biol Cell. 2012 Apr;23(7):1343-53.
REF 89 Endosomal type I PIP 5-kinase controls EGF receptor lysosomal sorting. Dev Cell. 2013 Apr 29;25(2):144-55.
REF 90 Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration. J Biol Chem. 2011 Jan 7;286(1):620-33.

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