Target General Information
Target ID T68251 Target Info
Target Name Matrix metalloproteinase-2 (MMP-2)
Synonyms TBE-1; Matrix metalloproteinase 2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase
Target Type Successful Target
Gene Name MMP2
Biochemical Class Peptidase
UniProt ID
MMP2_HUMAN 
Target Interacting Proteins
Growth factors [+] 1 Growth factors +
Interacting Target Name Transforming growth factor beta 1 (TGFB1) Successful Target Interacting Protein Info
UniProt ID
TGFB1_HUMAN 
Synonyms Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1; TGF-beta1; TGF-beta 1; TGFB
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [1]
2 Co-localization [2]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Metalloproteinase inhibitor 2 (TIMP2) Interacting Protein Interacting Protein Info
UniProt ID
TIMP2_HUMAN 
Synonyms CSC.21K; DDC8; KIAA1731NL
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-crystal Structure [4]
3 Reconstituted Complex [5]
Interacting Protein Name Alpha-2-macroglobulin (A2M) Interacting Protein Interacting Protein Info
UniProt ID
A2MG_HUMAN 
Synonyms A2MD; CPAMD5; FWP007; S863.7
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [2]
2 Reconstituted Complex [6]
Interacting Protein Name Metalloproteinase inhibitor 3 (TIMP3) Interacting Protein Interacting Protein Info
UniProt ID
TIMP3_HUMAN 
Synonyms HSMRK222; K222; K222TA2; SFD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Reconstituted Complex [7]
References
REF 1 Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 2000 Jan 15;14(2):163-76.
REF 2 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7414-9.
REF 5 Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain. J Biol Chem. 2002 Dec 13;277(50):48696-707.
REF 6 Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin. Arch Biochem Biophys. 1997 Nov 1;347(1):62-8.
REF 7 Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions. J Biol Chem. 1999 Apr 16;274(16):10846-51.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.