Target General Information
Target ID T75243 Target Info
Target Name Serine/threonine-protein kinase mTOR (mTOR)
Synonyms Target of rapamycin; TOR kinase; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAPT1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP12-rapamycin complex-associated protein; FKBP-rapamycin associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Target Type Successful Target
Gene Name MTOR
Biochemical Class Kinase
UniProt ID
MTOR_HUMAN 
Target Interacting Proteins
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name GTP-binding protein Rheb (RHEB) Interacting Protein Interacting Protein Info
UniProt ID
RHEB_HUMAN 
Synonyms RHEB2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-localization [3]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name Regulatory-associated protein of mTOR (RPTOR) Interacting Protein Interacting Protein Info
UniProt ID
RPTOR_HUMAN 
Synonyms KOG1; Mip1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [7]
5 Affinity Capture-MS [8]
6 Affinity Capture-MS [9]
7 Affinity Capture-MS [10]
8 Affinity Capture-Western [4]
9 Affinity Capture-Western [11]
10 Affinity Capture-Western [12]
11 Affinity Capture-Western [13]
12 Affinity Capture-Western [14]
13 Affinity Capture-Western [5]
14 Affinity Capture-Western [15]
15 Affinity Capture-Western [16]
16 Affinity Capture-Western [17]
17 Affinity Capture-Western [18]
18 Affinity Capture-Western [19]
19 Affinity Capture-Western [20]
20 Affinity Capture-Western [21]
Interacting Protein Name Target of rapamycin complex subunit LST8 (MLST8) Interacting Protein Interacting Protein Info
UniProt ID
LST8_HUMAN 
Synonyms GBL; GbetaL; LST8; POP3; WAT1
Evidence Score (E-score) 17 Experimental Evidences +
1 Affinity Capture-MS [22]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [7]
4 Affinity Capture-MS [23]
5 Affinity Capture-MS [9]
6 Affinity Capture-Western [24]
7 Affinity Capture-Western [13]
8 Affinity Capture-Western [20]
9 Affinity Capture-Western [25]
10 Affinity Capture-Western [26]
11 Affinity Capture-Western [27]
12 Affinity Capture-Western [23]
13 Affinity Capture-Western [9]
14 Affinity Capture-Western [28]
15 Affinity Capture-Western [29]
16 Affinity Capture-Western [30]
17 Affinity Capture-Western [31]
Eukaryotic initiation factors [+] 1 Eukaryotic initiation factors +
Interacting Target Name Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) Literature-reported Target Interacting Protein Info
UniProt ID
4EBP1_HUMAN 
Synonyms Phosphorylated heat- andacid-stable protein regulated by insulin 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; eIF4E-binding protein 1; 4E-BP1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [32]
3 Biochemical Activity [33]
4 Biochemical Activity [34]
5 Biochemical Activity [35]
6 Biochemical Activity [36]
7 Biochemical Activity [12]
8 Biochemical Activity [13]
9 Biochemical Activity [37]
10 Biochemical Activity [38]
11 Biochemical Activity [39]
12 Biochemical Activity [40]
13 Biochemical Activity [6]
14 Biochemical Activity [41]
15 Biochemical Activity [26]
16 Biochemical Activity [27]
17 Biochemical Activity [42]
18 Biochemical Activity [43]
19 Biochemical Activity [44]
20 Biochemical Activity [45]
Isomerases [+] 2 Isomerases +
Interacting Target Name FK506-binding protein 1A (FKBP1A) Successful Target Interacting Protein Info
UniProt ID
FKB1A_HUMAN 
Synonyms Rotamase; PPIase FKBP1A; Peptidyl-prolyl cis-trans isomerase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP-1A; FKBP-12; FKBP12; FKBP1; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Co-crystal Structure [46]
3 Co-fractionation [47]
4 Protein-Fragment Complementation Assay [48]
5 Protein-Fragment Complementation Assay [49]
6 Reconstituted Complex [50]
7 Reconstituted Complex [32]
8 Yeast two hybrid [51]
Interacting Protein Name Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) Interacting Protein Interacting Protein Info
UniProt ID
FKBP8_HUMAN 
Synonyms FKBP38; FKBPr38
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [52]
2 Affinity Capture-Western [32]
3 Reconstituted Complex [32]
Kinases [+] 2 Kinases +
Interacting Target Name Ribosomal protein S6 kinase beta-1 (S6K1) Clinical trial Target Interacting Protein Info
UniProt ID
KS6B1_HUMAN 
Synonyms STK14A; Serine/threonine-protein kinase 14A; S6K-beta-1; S6K; Ribosomal protein S6 kinase I; P70S6K1; p70-S6K 1; P70-S6K; p70 S6K-alpha; p70 S6KA; p70 S6 kinase alpha; p70 ribosomal S6 kinase alpha; 70 kDa ribosomal protein S6 kinase 1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [54]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [55]
6 Biochemical Activity [56]
7 Biochemical Activity [38]
8 Biochemical Activity [20]
9 Biochemical Activity [41]
10 Biochemical Activity [26]
11 Biochemical Activity [9]
12 Biochemical Activity [28]
13 Biochemical Activity [10]
14 Biochemical Activity [57]
15 Reconstituted Complex [58]
16 Reconstituted Complex [2]
17 Reconstituted Complex [59]
18 Reconstituted Complex [60]
19 Reconstituted Complex [61]
20 Reconstituted Complex [62]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Clinical trial Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Biochemical Activity [64]
3 Biochemical Activity [65]
4 Biochemical Activity [66]
5 Biochemical Activity [63]
6 Biochemical Activity [67]
7 Biochemical Activity [18]
8 Biochemical Activity [68]
9 Biochemical Activity [20]
10 Biochemical Activity [21]
11 Biochemical Activity [25]
12 Co-localization [69]
13 Protein-peptide [70]
14 Reconstituted Complex [71]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [72]
2 Affinity Capture-Western [73]
3 Biochemical Activity [36]
4 Reconstituted Complex [74]
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [75]
2 Co-fractionation [76]
3 Co-localization [77]
Other proteins [+] 6 Other proteins +
Interacting Target Name MTOR complex 2 (RICTOR) Literature-reported Target Interacting Protein Info
UniProt ID
RICTR_HUMAN 
Synonyms Rapamycin-insensitive companion of mTOR; KIAA1999; hAVO3; AVO3 homolog
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [10]
5 Affinity Capture-Western [15]
6 Affinity Capture-Western [14]
7 Affinity Capture-Western [5]
8 Affinity Capture-Western [78]
9 Affinity Capture-Western [79]
10 Affinity Capture-Western [63]
11 Affinity Capture-Western [67]
12 Affinity Capture-Western [16]
13 Affinity Capture-Western [18]
14 Affinity Capture-Western [19]
15 Affinity Capture-Western [68]
16 Affinity Capture-Western [20]
17 Affinity Capture-Western [21]
18 Affinity Capture-Western [25]
19 Affinity Capture-Western [6]
20 Affinity Capture-Western [24]
Interacting Target Name Target of rapamycin complex 2 MAPKAP1 (MTORC2) Clinical trial Target Interacting Protein Info
UniProt ID
SIN1_HUMAN 
Synonyms TORC2 subunit MAPKAP1; Target of rapamycin complex 2 subunit MAPKAP1; Stress-activated map kinase-interacting protein 1; SIN1; SAPK-interacting protein 1; mSIN1; Mitogen-activated protein kinase 2-associated protein 1; MIP1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [80]
4 Affinity Capture-Western [63]
5 Affinity Capture-Western [19]
6 Affinity Capture-Western [20]
7 Affinity Capture-Western [25]
8 Affinity Capture-Western [6]
9 Co-fractionation [16]
Interacting Protein Name Proline-rich AKT1 substrate 1 (AKT1S1) Interacting Protein Interacting Protein Info
UniProt ID
AKTS1_HUMAN 
Synonyms Lobe; PRAS40
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [24]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [41]
6 Affinity Capture-Western [80]
7 Affinity Capture-Western [81]
8 Biochemical Activity [6]
Interacting Target Name DEP domain-containing protein 6 (DEPTOR) Literature-reported Target Interacting Protein Info
UniProt ID
DPTOR_HUMAN 
Synonyms DEPDC6; DEP domain-containing protein 6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Biochemical Activity [82]
3 Biochemical Activity [83]
Interacting Target Name Insulin receptor substrate-1 (IRS1) Literature-reported Target Interacting Protein Info
UniProt ID
IRS1_HUMAN 
Synonyms IRS-1; Insulin receptor substrate 1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [84]
2 Biochemical Activity [84]
3 Biochemical Activity [40]
Interacting Protein Name TELO2-interacting protein 1 homolog (TTI1) Interacting Protein Interacting Protein Info
UniProt ID
TTI1_HUMAN 
Synonyms KIAA0406; smg.10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-Western [29]
References
REF 1 Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett. 2005 Aug 29;579(21):4763-8.
REF 2 Rheb binds and regulates the mTOR kinase. Curr Biol. 2005 Apr 26;15(8):702-13.
REF 3 TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015;11(7):1052-62.
REF 4 Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002 Jul 26;110(2):177-89.
REF 5 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004 Jul 27;14(14):1296-302.
REF 6 PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One. 2007 Nov 21;2(11):e1217.
REF 7 Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol. 2007 Mar;9(3):316-23.
REF 8 mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 2002 Jul 26;110(2):163-75.
REF 9 GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell. 2003 Apr;11(4):895-904.
REF 10 Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). J Biol Chem. 2012 Jun 15;287(25):21164-75.
REF 11 Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008 Jun 1;22(11):1490-500.
REF 12 Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17414-9.
REF 13 Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem. 2006 Aug 25;281(34):24293-303.
REF 14 Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 2004 Nov;6(11):1122-8.
REF 15 SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 6;127(1):125-37.
REF 16 Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15;20(20):2820-32.
REF 17 Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J. 2007 Aug 1;405(3):513-22.
REF 18 mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010 Dec 1;29(23):3939-51.
REF 19 The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway. EMBO J. 2009 Dec 16;28(24):3879-92.
REF 20 Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Biochem Biophys Res Commun. 2008 Aug 8;372(4):578-83.
REF 21 IKK interacts with rictor and regulates mTORC2. Cell Signal. 2013 Nov;25(11):2239-45.
REF 22 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
REF 23 Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers. Virchows Arch. 2003 Jul;443(1):78-86.
REF 24 DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009 May 29;137(5):873-86.
REF 25 Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein. J Biol Chem. 2012 Jan 2;287(1):581-8.
REF 26 Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells. 2004 Apr;9(4):359-66.
REF 27 Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. Mol Endocrinol. 2005 Jan;19(1):175-83.
REF 28 Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J Biol Chem. 2005 Nov 25;280(47):39505-9.
REF 29 Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem. 2010 Jun 25;285(26):20109-16.
REF 30 Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro. Autophagy. 2012 Feb 1;8(2):213-21.
REF 31 Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. Mol Cell Biol. 2011 Apr;31(8):1657-71.
REF 32 Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science. 2007 Nov 9;318(5852):977-80.
REF 33 Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Mol Cell Biol. 2006 Jan;26(1):277-92.
REF 34 cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. EMBO J. 2008 Apr 9;27(7):1005-16.
REF 35 Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size. Genes Cells. 2006 Jul;11(7):757-66.
REF 36 mTORC1 drives HIF-1 and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene. 2015 Apr 23;34(17):2239-50.
REF 37 Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol. 2005 Apr;25(7):2558-72.
REF 38 The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem. 2003 May 2;278(18):15461-4.
REF 39 IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 2007 Aug 10;130(3):440-55.
REF 40 Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCF-TRCP E3Ubiquitin Ligase. iScience. 2018 Jul 27;5:1-18.
REF 41 PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 2007 Mar 23;25(6):903-15.
REF 42 ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy. 2011 Jul;7(7):737-47.
REF 43 Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol. 2008 Sep 9;18(17):1269-77.
REF 44 Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor. J Biol Chem. 2003 May 30;278(22):19667-73.
REF 45 DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol. 2010 Jun 22;20(12):1093-8.
REF 46 Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 1996 Jul 12;273(5272):239-42.
REF 47 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 48 Dual-color click beetle luciferase heteroprotein fragment complementation assays. Chem Biol. 2010 Sep 24;17(9):1018-29.
REF 49 A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography. Nat Med. 2010 Aug;16(8):921-6.
REF 50 Characterization of the FKBP.rapamycin.FRB ternary complex. J Am Chem Soc. 2005 Apr 6;127(13):4715-21.
REF 51 Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12288-93.
REF 52 Lysophosphatidic acid acyltransferase beta regulates mTOR signaling. PLoS One. 2013 Oct 31;8(10):e78632.
REF 53 Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res. 2003 Dec 1;63(23):8451-60.
REF 54 Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro. Genes Cells. 2000 Sep;5(9):765-75.
REF 55 Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer. Oncotarget. 2015 Feb 28;6(6):4080-96.
REF 56 The FRB domain of mTOR: NMR solution structure and inhibitor design. Biochemistry. 2006 Aug 29;45(34):10294-302.
REF 57 MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability. Mol Cancer. 2017 Mar 7;16(1):55.
REF 58 Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J Biol Chem. 1999 Nov 26;274(48):34493-8.
REF 59 RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7.
REF 60 Characterization of the cloned full-length and a truncated human target of rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay. Biochem Biophys Res Commun. 2005 Jun 24;332(1):304-10.
REF 61 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem. 2005 May 20;280(20):19445-8.
REF 62 Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem. 2002 May 31;277(22):20104-12.
REF 63 The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23;27(14):1932-43.
REF 64 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005 Feb 18;307(5712):1098-101.
REF 65 Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A. Mol Biol Cell. 2012 Apr;23(7):1243-53.
REF 66 ER stress inhibits mTORC2 and Akt signaling through GSK-3-mediated phosphorylation of rictor. Sci Signal. 2011 Feb 22;4(161):ra10.
REF 67 A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. J Biol Chem. 2011 Mar 4;286(9):7182-9.
REF 68 Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23;27(14):1919-31.
REF 69 COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol. 2015 Mar;24(1):55-70.
REF 70 Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem. 2004 Apr 16;279(16):15719-22.
REF 71 A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000 Jul 1;60(13):3504-13.
REF 72 Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J Biol Chem. 2005 Jan 14;280(2):1037-43.
REF 73 Gadd45a suppresses tumor angiogenesis via inhibition of the mTOR/STAT3 protein pathway. J Biol Chem. 2013 Mar 1;288(9):6552-60.
REF 74 Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol. 2000 Jan 13;10(1):47-50.
REF 75 Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J Biol Chem. 2003 Sep 5;278(36):33637-44.
REF 76 Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion. J Biol Chem. 2009 Sep 4;284(36):24341-53.
REF 77 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 78 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J Biol Chem. 2015 May 29;290(22):14120-9.
REF 79 Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res. 2008 Mar 15;68(6):1618-24.
REF 80 mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell. 2008 Jun 20;30(6):701-11.
REF 81 Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol. 2009 Mar;29(6):1411-20.
REF 82 mTOR generates an auto-amplification loop by triggering the TrCP- and CK1-dependent degradation of DEPTOR. Mol Cell. 2011 Oct 21;44(2):317-24.
REF 83 mTOR drives its own activation via SCF(TrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011 Oct 21;44(2):290-303.
REF 84 Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006 Jan;26(1):63-76.

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