Target General Information
Target ID T84780 Target Info
Target Name Cellular inhibitor of apoptosis 1 (BIRC2)
Synonyms hIAP2; hIAP-2; TNFR2TRAFsignaling complex protein 2; TNFR2-TRAF-signaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; CIAP1; C-IAP1; Baculoviral IAP repeatcontaining protein 2; Baculoviral IAP repeat-containing protein 2; API1
Target Type Clinical trial Target
Gene Name BIRC2
Biochemical Class Acyltransferase
UniProt ID
BIRC2_HUMAN 
Target Interacting Proteins
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Ras-related C3 botulinum toxin substrate 1 (RAC1) Literature-reported Target Interacting Protein Info
UniProt ID
RAC1_HUMAN 
Synonyms TC25; Ras-like protein TC25; p21-Rac1; MIG5; Cell migration-inducing gene5 protein; Cell migration-inducing gene 5 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-Western [1]
3 Biochemical Activity [2]
4 Reconstituted Complex [3]
Interacting Protein Name Cell division control protein 42 homolog (CDC42) Interacting Protein Interacting Protein Info
UniProt ID
CDC42_HUMAN 
Synonyms CDC42Hs; G25K
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [4]
2 Reconstituted Complex [3]
Acyltransferases [+] 3 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [8]
5 Affinity Capture-Western [9]
6 Affinity Capture-Western [10]
7 Affinity Capture-Western [11]
8 Affinity Capture-Western [12]
9 Affinity Capture-Western [13]
10 Affinity Capture-Western [14]
11 Affinity Capture-Western [15]
12 Biochemical Activity [6]
13 Biochemical Activity [16]
14 Biochemical Activity [17]
15 Co-localization [18]
16 Reconstituted Complex [6]
17 Reconstituted Complex [19]
18 Reconstituted Complex [20]
19 Reconstituted Complex [3]
20 Reconstituted Complex [8]
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [13]
3 Affinity Capture-Western [22]
Interacting Target Name Melanoma inhibitor of apoptosis protein (ML-IAP) Patented-recorded Target Interacting Protein Info
UniProt ID
BIRC7_HUMAN 
Synonyms UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-Western [23]
3 Yeast two hybrid [24]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [21]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [11]
4 Reconstituted Complex [6]
5 Reconstituted Complex [19]
6 Reconstituted Complex [20]
7 Yeast two hybrid [25]
8 Yeast two hybrid [26]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Endoplasmin (HSP90B1) Clinical trial Target Interacting Protein Info
UniProt ID
ENPL_HUMAN 
Synonyms Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP-94; GRP94; gp96 homolog; 94 kDa glucose-regulated protein; 94 kDa glucoseregulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Fluorescence Resonance Energy Transfer [27]
Kinases [+] 2 Kinases +
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [30]
4 Affinity Capture-Western [31]
5 Biochemical Activity [32]
6 Biochemical Activity [24]
7 Biochemical Activity [33]
8 Biochemical Activity [30]
9 Biochemical Activity [29]
10 Reconstituted Complex [29]
Interacting Protein Name Receptor-interacting protein 2 (RIP2) Interacting Protein Interacting Protein Info
UniProt ID
RIPK2_HUMAN 
Synonyms UNQ277/PRO314/PRO34092; Tyrosine-protein kinase RIPK2; RIP-like-interacting CLARP kinase; RIP-2; RIP2; RICK; Receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting protein 2; CARDIAK; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [35]
4 Biochemical Activity [29]
5 Reconstituted Complex [35]
6 Reconstituted Complex [29]
7 Reconstituted Complex [36]
Peptidases [+] 4 Peptidases +
Interacting Target Name Caspase-9 (CASP9) Clinical trial Target Interacting Protein Info
UniProt ID
CASP9_HUMAN 
Synonyms MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [39]
4 Affinity Capture-Western [40]
5 Affinity Capture-Western [30]
6 Co-crystal Structure [41]
7 Co-localization [18]
8 Protein-peptide [41]
9 Reconstituted Complex [37]
10 Reconstituted Complex [42]
11 Yeast two hybrid [43]
Interacting Target Name Caspase-7 (CASP7) Clinical trial Target Interacting Protein Info
UniProt ID
CASP7_HUMAN 
Synonyms MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [44]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [39]
4 Biochemical Activity [45]
5 Reconstituted Complex [45]
6 Reconstituted Complex [20]
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Biochemical Activity [45]
3 Reconstituted Complex [45]
4 Reconstituted Complex [20]
Interacting Protein Name High temperature requirement protein A2 (HTRA2) Interacting Protein Interacting Protein Info
UniProt ID
HTRA2_HUMAN 
Synonyms OMI; PARK13; PRSS25
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-MS [21]
3 Affinity Capture-Western [47]
4 Affinity Capture-Western [48]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [49]
2 Affinity Capture-Western [10]
3 Biochemical Activity [49]
4 Reconstituted Complex [49]
Ubiquitin related proteins [+] 6 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Interacting Protein Interacting Protein Info
UniProt ID
UB2D1_HUMAN 
Synonyms E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Reconstituted Complex [32]
3 Reconstituted Complex [24]
4 Reconstituted Complex [51]
5 Reconstituted Complex [52]
6 Reconstituted Complex [53]
7 Reconstituted Complex [30]
8 Reconstituted Complex [49]
9 Reconstituted Complex [2]
10 Reconstituted Complex [29]
11 Reconstituted Complex [54]
12 Yeast two hybrid [24]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [55]
2 Reconstituted Complex [56]
3 Reconstituted Complex [24]
4 Reconstituted Complex [57]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Interacting Protein Interacting Protein Info
UniProt ID
UB2D2_HUMAN 
Synonyms E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [58]
2 Reconstituted Complex [6]
3 Reconstituted Complex [45]
4 Yeast two hybrid [24]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Interacting Protein Interacting Protein Info
UniProt ID
UB2D3_HUMAN 
Synonyms E2(17)KB3; UBC4/5; UBCH5C
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Reconstituted Complex [50]
3 Yeast two hybrid [24]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Interacting Protein Interacting Protein Info
UniProt ID
UB2J1_HUMAN 
Synonyms HSPC153; HSPC205; HSU93243; NCUBE.1; NCUBE1; UBC6; Ubc6p
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [59]
2 Reconstituted Complex [14]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 S (UBE2S) Interacting Protein Interacting Protein Info
UniProt ID
UBE2S_HUMAN 
Synonyms E2.EPF; E2EPF; EPF5
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [51]
2 Yeast two hybrid [24]
Other proteins [+] 5 Other proteins +
Interacting Target Name Direct IAP-binding protein with low pI (DIABLO) Literature-reported Target Interacting Protein Info
UniProt ID
DBLOH_HUMAN 
Synonyms Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [50]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [60]
6 Biochemical Activity [61]
7 Biochemical Activity [50]
8 Co-crystal Structure [41]
9 Protein-peptide [41]
10 Reconstituted Complex [62]
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [63]
2 Reconstituted Complex [64]
3 Reconstituted Complex [63]
4 Reconstituted Complex [65]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [66]
3 Affinity Capture-Western [67]
4 Biochemical Activity [68]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [69]
2 Affinity Capture-Western [70]
Interacting Target Name CD40L receptor (CD40) Clinical trial Target Interacting Protein Info
UniProt ID
TNR5_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 5; TNFRSF5; CDw40; CD40L receptor; Bp50; B-cell surfaceantigen CD40; B-cell surface antigen CD40
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [71]
2 Affinity Capture-Western [72]
References
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