Target General Information
Target ID T86591 Target Info
Target Name Peroxisome proliferator-activated receptor alpha (PPARA)
Synonyms Peroxisome proliferater-activated receptor alpha; PPARalpha; PPAR-alpha; PPAR; Nuclear receptor subfamily 1 group C member 1; NR1C1
Target Type Successful Target
Gene Name PPARA
Biochemical Class Nuclear hormone receptor
UniProt ID
PPARA_HUMAN 
Target Interacting Proteins
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Literature-reported Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [1]
2 Yeast two hybrid [2]
3 Yeast two hybrid [1]
4 Yeast two hybrid [3]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 4 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [4]
2 Reconstituted Complex [5]
3 Reconstituted Complex [6]
4 Yeast two hybrid [2]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [8]
3 Reconstituted Complex [6]
4 Reconstituted Complex [9]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [1]
3 Yeast two hybrid [1]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-crystal Structure [11]
References
REF 1 Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein. J Biol Chem. 1999 May 28;274(22):15901-7.
REF 2 p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha. J Biol Chem. 1997 Dec 26;272(52):33435-43.
REF 3 PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):298-302.
REF 4 Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor alpha. J Steroid Biochem Mol Biol. 2002 Jul;81(3):217-25.
REF 5 A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol. 1998 Jun;12(6):864-81.
REF 6 Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005 Jul 15;280(28):26543-56.
REF 7 Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol Cancer Res. 2012 Mar;10(3):441-53.
REF 8 Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. Mol Cell Endocrinol. 1999 Jan 25;147(1-2):37-47.
REF 9 Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J Lipid Res. 2003 Apr;44(4):686-95.
REF 10 SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J Biol Chem. 2010 Feb 26;285(9):5983-92.
REF 11 Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7.

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