Target General Information
Target ID T89534 Target Info
Target Name Estrogen receptor (ESR)
Synonyms Nuclear receptor subfamily 3 group A member 1; NR3A1; Estradiol receptor; ESR; ER-alpha; ER
Target Type Successful Target
Gene Name ESR1
Biochemical Class Nuclear hormone receptor
UniProt ID
ESR1_HUMAN 
Target Interacting Proteins
Acid anhydride hydrolases [+] 6 Acid anhydride hydrolases +
Interacting Target Name ATP-dependent RNA helicase DDX5 (DDX5) Clinical trial Target Interacting Protein Info
UniProt ID
DDX5_HUMAN 
Synonyms RNA helicase p68; Probable ATP-dependent RNA helicase DDX5; HLR1; HELR; G17P1; DEAD box protein 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Yeast two hybrid [3]
Interacting Protein Name ATP-dependent RNA helicase DDX3X (DDX3X) Interacting Protein Interacting Protein Info
UniProt ID
DDX3X_HUMAN 
Synonyms CAP.Rf; DBX; DDX14; DDX3; HLP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [4]
Interacting Protein Name Unconventional myosin-Ic (MYO1C) Interacting Protein Interacting Protein Info
UniProt ID
MYO1C_HUMAN 
Synonyms MMI.beta; MMIb; NMI; myr2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Protein Name Probable ATP-dependent RNA helicase DDX17 (DDX17) Interacting Protein Interacting Protein Info
UniProt ID
DDX17_HUMAN 
Synonyms P72; RH70
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
3 Yeast two hybrid [3]
Interacting Protein Name ATP-dependent RNA helicase A (DHX9) Interacting Protein Interacting Protein Info
UniProt ID
DHX9_HUMAN 
Synonyms DDX9; LKP; NDH2; NDHII; RHA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Eukaryotic initiation factor 4A-I (EIF4A1) Interacting Protein Interacting Protein Info
UniProt ID
IF4A1_HUMAN 
Synonyms DDX2A; EIF.4A; EIF4A; eIF.4A.I; eIF4A.I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Actins [+] 4 Actins +
Interacting Protein Name Beta-actin (ACTB) Interacting Protein Interacting Protein Info
UniProt ID
ACTB_HUMAN 
Synonyms BRWS1; PS1TP5BP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Reconstituted Complex [4]
Interacting Protein Name Actin-related protein 2 (ACTR2) Interacting Protein Interacting Protein Info
UniProt ID
ARP2_HUMAN 
Synonyms ARP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Protein Name Actin-related protein 3 (ACTR3) Interacting Protein Interacting Protein Info
UniProt ID
ARP3_HUMAN 
Synonyms ARP3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Protein Name Alpha-cardiac actin (ACTC1) Interacting Protein Interacting Protein Info
UniProt ID
ACTC_HUMAN 
Synonyms ACTC; ASD5; CMD1R; CMH11; LVNC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Acyltransferases [+] 8 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [8]
6 Fluorescence Resonance Energy Transfer [9]
7 Fluorescence Resonance Energy Transfer [10]
8 Protein-peptide [11]
9 Reconstituted Complex [12]
10 Reconstituted Complex [13]
11 Reconstituted Complex [14]
12 Reconstituted Complex [6]
13 Reconstituted Complex [15]
14 Reconstituted Complex [16]
15 Reconstituted Complex [3]
16 Reconstituted Complex [17]
17 Reconstituted Complex [18]
18 Reconstituted Complex [19]
19 Reconstituted Complex [20]
20 Reconstituted Complex [21]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [22]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [23]
6 Affinity Capture-Western [24]
7 Affinity Capture-Western [25]
8 Affinity Capture-Western [26]
9 Affinity Capture-Western [27]
10 Affinity Capture-Western [28]
11 Affinity Capture-Western [29]
12 Co-fractionation [30]
13 Fluorescence Resonance Energy Transfer [27]
14 Fluorescence Resonance Energy Transfer [10]
15 Fluorescence Resonance Energy Transfer [31]
16 Protein-peptide [11]
17 Reconstituted Complex [6]
18 Reconstituted Complex [32]
19 Reconstituted Complex [33]
20 Reconstituted Complex [24]
Interacting Target Name Histone acetyltransferase p300 (EP300) Literature-reported Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [36]
5 Biochemical Activity [37]
6 Reconstituted Complex [34]
7 Reconstituted Complex [14]
8 Reconstituted Complex [32]
9 Reconstituted Complex [4]
10 Reconstituted Complex [17]
11 Yeast two hybrid [3]
12 Yeast two hybrid [17]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [39]
5 Affinity Capture-Western [40]
6 Affinity Capture-Western [41]
7 Affinity Capture-Western [42]
8 Affinity Capture-Western [43]
9 Affinity Capture-Western [44]
10 Reconstituted Complex [45]
11 Reconstituted Complex [41]
12 Reconstituted Complex [43]
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-Western [47]
3 Affinity Capture-Western [48]
4 Affinity Capture-Western [49]
5 Reconstituted Complex [48]
Interacting Target Name Linear ubiquitin chain assembly complex (RBCK1) Literature-reported Target Interacting Protein Info
UniProt ID
HOIL1_HUMAN 
Synonyms XAP4; XAP3; Ubiquitin-conjugating enzyme 7-interacting protein 3; UBCE7IP3; RNF54; RING-type E3 ubiquitin transferase HOIL-1; RING finger protein 54; RanBP-type and C3HC4-type zinc finger-containing protein 1; HOIL-1; Hepatitis B virus X-associated protein 4; Heme-oxidized IRP2 ubiquitin ligase 1; HBV-associated factor 4; C20orf18
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Affinity Capture-Western [51]
3 Reconstituted Complex [50]
Interacting Target Name Tripartite motif-containing 24 (TRIM24) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1A_HUMAN 
Synonyms Tripartite motif-containing protein 24; Transcription intermediary factor 1-alpha; TIF1-alpha; TIF1A; TIF1; RNF82; RING-type E3 ubiquitin transferase TIF1-alpha; RING finger protein 82; E3 ubiquitin-protein ligase TRIM24
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [52]
3 Reconstituted Complex [21]
Interacting Protein Name E3 ubiquitin-protein ligase HECTD1 (HECTD1) Interacting Protein Interacting Protein Info
UniProt ID
HECD1_HUMAN 
Synonyms EULIR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [53]
2 Affinity Capture-Western [23]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) Interacting Protein Interacting Protein Info
UniProt ID
TAB2_HUMAN 
Synonyms CHTD2; MAP3K7IP2; TAB.2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Affinity Capture-Western [55]
3 Affinity Capture-Western [56]
4 Reconstituted Complex [55]
5 Reconstituted Complex [56]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Caveolin 1 (CAV1) Literature-reported Target Interacting Protein Info
UniProt ID
CAV1_HUMAN 
Synonyms Caveolin-1; Caveolin1; Cav-1; CAV
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Co-localization [58]
3 Reconstituted Complex [57]
Beta-transducin repeats [+] 3 Beta-transducin repeats +
Interacting Target Name WD repeat-containing protein 5 (WDR5) Literature-reported Target Interacting Protein Info
UniProt ID
WDR5_HUMAN 
Synonyms BMP2-induced 3-kb gene protein; BIG3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
Interacting Protein Name Histone-binding protein RBBP4 (RBBP4) Interacting Protein Interacting Protein Info
UniProt ID
RBBP4_HUMAN 
Synonyms NURF55; RBAP48; lin.53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [61]
Interacting Protein Name Histone-binding protein RBBP7 (RBBP7) Interacting Protein Interacting Protein Info
UniProt ID
RBBP7_HUMAN 
Synonyms RbAp46
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [61]
Carbon-nitrogen hydrolases [+] 3 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [62]
3 Affinity Capture-Western [63]
4 Co-localization [64]
5 Reconstituted Complex [65]
Interacting Target Name Histone deacetylase 4 (HDAC4) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC4_HUMAN 
Synonyms KIAA0288; HD4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [66]
2 Reconstituted Complex [67]
3 Reconstituted Complex [66]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [55]
3 Reconstituted Complex [4]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Reconstituted Complex [45]
3 Yeast two hybrid [68]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Serine/threonine PP1-alpha (PPP1CA) Successful Target Interacting Protein Info
UniProt ID
PP1A_HUMAN 
Synonyms Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase 1alpha; PPP1A; PP-1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name PP2A subunit A isoform PR65-alpha (PPP2R1A) Interacting Protein Interacting Protein Info
UniProt ID
2AAA_HUMAN 
Synonyms PP2A.Aalpha; PP2AAALPHA; PR65A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [53]
2 Reconstituted Complex [4]
Heat shock proteins [+] 4 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Luminescence [69]
2 Affinity Capture-MS [46]
3 Affinity Capture-Western [70]
4 Affinity Capture-Western [48]
5 Affinity Capture-Western [49]
6 Affinity Capture-Western [71]
7 Affinity Capture-Western [47]
8 Affinity Capture-Western [72]
9 Affinity Capture-Western [51]
10 Reconstituted Complex [73]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [74]
2 Affinity Capture-MS [46]
3 Affinity Capture-Western [48]
4 Affinity Capture-Western [72]
5 Affinity Capture-Western [74]
6 Reconstituted Complex [73]
7 Reconstituted Complex [4]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [46]
4 Affinity Capture-Western [47]
5 Affinity Capture-Western [48]
6 Affinity Capture-Western [46]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [75]
2 Reconstituted Complex [4]
Isomerases [+] 3 Isomerases +
Interacting Protein Name Prostaglandin E synthase 3 (PTGES3) Interacting Protein Interacting Protein Info
UniProt ID
TEBP_HUMAN 
Synonyms P23; TEBP; cPGES
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-Western [49]
3 Reconstituted Complex [73]
Interacting Target Name DNA topoisomerase II beta (TOP2B) Successful Target Interacting Protein Info
UniProt ID
TOP2B_HUMAN 
Synonyms Topo IIbeta; TOP2beta; TOP2B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [76]
Interacting Target Name FK506-binding protein 5 (FKBP5) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP5_HUMAN 
Synonyms PPIase FKBP5; Peptidyl-prolyl cis-trans isomerase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP-51; FKBP51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Reconstituted Complex [73]
Kinases [+] 5 Kinases +
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Affinity Capture-Western [78]
3 Co-localization [79]
4 Co-localization [64]
5 Co-localization [80]
6 Fluorescence Resonance Energy Transfer [79]
7 Reconstituted Complex [80]
8 Yeast two hybrid [81]
9 Yeast two hybrid [82]
10 Yeast two hybrid [79]
11 Yeast two hybrid [83]
Interacting Target Name PAK-1 protein kinase (PAK1) Literature-reported Target Interacting Protein Info
UniProt ID
PAK1_HUMAN 
Synonyms Serine/threonine-protein kinase PAK 1; PAK-1; p65-PAK; p21-activated kinase 1; Alpha-PAK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [84]
2 Biochemical Activity [85]
3 Reconstituted Complex [85]
Interacting Protein Name DNA-directed RNA polymerase II subunit RPB1 (POLR2A) Interacting Protein Interacting Protein Info
UniProt ID
RPB1_HUMAN 
Synonyms POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [80]
3 Reconstituted Complex [4]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [86]
2 Affinity Capture-Western [87]
Interacting Target Name DNA-dependent protein kinase catalytic (PRKDC) Clinical trial Target Interacting Protein Info
UniProt ID
PRKDC_HUMAN 
Synonyms P460; HYRC1; HYRC; DNPK1; DNA-PKcs; DNA-PK catalytic subunit; DNA-PK; DNA-dependent protein kinase catalytic subunit; DNA-dependent protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [76]
Mediator complexes [+] 3 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [88]
2 Affinity Capture-Western [14]
3 Fluorescence Resonance Energy Transfer [9]
4 Reconstituted Complex [89]
5 Reconstituted Complex [14]
6 Reconstituted Complex [3]
7 Reconstituted Complex [88]
8 Reconstituted Complex [9]
9 Yeast two hybrid [3]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 12 (MED12) Interacting Protein Interacting Protein Info
UniProt ID
MED12_HUMAN 
Synonyms ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [14]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 14 (MED14) Interacting Protein Interacting Protein Info
UniProt ID
MED14_HUMAN 
Synonyms CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [88]
3 Reconstituted Complex [14]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor beta (ESR2) Successful Target Interacting Protein Info
UniProt ID
ESR2_HUMAN 
Synonyms Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; ESTRB; ER-beta; Erbeta; Beta-1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Luminescence [90]
2 Affinity Capture-MS [91]
3 Affinity Capture-Western [92]
4 Affinity Capture-Western [93]
5 Co-purification [94]
6 Reconstituted Complex [95]
7 Yeast two hybrid [82]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Protein Name Histone-lysine N-methyltransferase 2D (KMT2D) Interacting Protein Interacting Protein Info
UniProt ID
KMT2D_HUMAN 
Synonyms AAD10; ALR; CAGL114; KABUK1; KMS; MLL2; MLL4; TNRC21
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
4 Co-localization [96]
Interacting Target Name Histone-lysine N-methyltransferase SETD7 (SETD7) Literature-reported Target Interacting Protein Info
UniProt ID
SETD7_HUMAN 
Synonyms SET9; SET7/9; SET7; SET domain-containing protein 7; Lysine N-methyltransferase 7; KMT7; KIAA1717; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [97]
2 Protein-peptide [97]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name S-nitrosoglutathione reductase (CBR1) Clinical trial Target Interacting Protein Info
UniProt ID
CBR1_HUMAN 
Synonyms ProstaglandinE(2) 9reductase; Prostaglandin 9ketoreductase; NADPHdependent carbonyl reductase 1; CBR1; Carbonyl reductase [NADPH] 1; 15hydroxyprostaglandin dehydrogenase [NADP(+)]
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [75]
2 Affinity Capture-MS [5]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [98]
2 Reconstituted Complex [99]
Ribosomal proteins [+] 8 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein eL18 (RPL18) Interacting Protein Interacting Protein Info
UniProt ID
RL18_HUMAN 
Synonyms L18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Large ribosomal subunit protein uL30 (RPL7) Interacting Protein Interacting Protein Info
UniProt ID
RL7_HUMAN 
Synonyms L7; humL7.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Large ribosomal subunit protein eL8 (RPL7A) Interacting Protein Interacting Protein Info
UniProt ID
RL7A_HUMAN 
Synonyms L7A; SURF3; TRUP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Large ribosomal subunit protein uL6 (RPL9) Interacting Protein Interacting Protein Info
UniProt ID
RL9_HUMAN 
Synonyms L9; NPC.A.16
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Large ribosomal subunit protein uL10 (RPLP0) Interacting Protein Interacting Protein Info
UniProt ID
RLA0_HUMAN 
Synonyms L10E; LP0; P0; PRLP0; RPP0
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Single copy abundant protein (RPS4X) Interacting Protein Interacting Protein Info
UniProt ID
RS4X_HUMAN 
Synonyms CCG2; DXS306; RPS4; S4; SCAR; SCR10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Small ribosomal subunit protein eS8 (RPS8) Interacting Protein Interacting Protein Info
UniProt ID
RS8_HUMAN 
Synonyms S8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Small ribosomal subunit protein uS4 (RPS9) Interacting Protein Interacting Protein Info
UniProt ID
RS9_HUMAN 
Synonyms S9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Transcription regulators [+] 13 Transcription regulators +
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [100]
3 Affinity Capture-Western [37]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [8]
6 Co-crystal Structure [101]
7 Fluorescence Resonance Energy Transfer [10]
8 Protein-peptide [11]
9 Reconstituted Complex [102]
10 Reconstituted Complex [13]
11 Reconstituted Complex [6]
12 Reconstituted Complex [103]
13 Reconstituted Complex [4]
14 Reconstituted Complex [104]
15 Yeast two hybrid [105]
16 Yeast two hybrid [13]
17 Yeast two hybrid [17]
18 Yeast two hybrid [82]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [36]
3 Affinity Capture-Western [77]
4 Reconstituted Complex [34]
5 Reconstituted Complex [15]
6 Yeast two hybrid [106]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Affinity Capture-Western [63]
3 Affinity Capture-Western [107]
4 Affinity Capture-Western [108]
5 Co-localization [109]
6 Reconstituted Complex [110]
Interacting Target Name Aryl hydrocarbon receptor (AHR) Successful Target Interacting Protein Info
UniProt ID
AHR_HUMAN 
Synonyms Class E basic helix-loop-helix protein 76; Class E basic helixloophelix protein 76; bHLHe76; AhR; Ah receptor
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [111]
2 Biochemical Activity [111]
3 Co-purification [111]
4 Reconstituted Complex [104]
5 Reconstituted Complex [110]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Affinity Capture-Western [55]
3 Co-localization [64]
4 Reconstituted Complex [3]
5 Yeast two hybrid [3]
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [112]
2 Reconstituted Complex [113]
3 Reconstituted Complex [33]
4 Yeast two hybrid [113]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [114]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [115]
4 Reconstituted Complex [115]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Reconstituted Complex [116]
3 Reconstituted Complex [3]
4 Yeast two hybrid [3]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [117]
3 Affinity Capture-Western [118]
Interacting Target Name CCAAT/enhancer binding protein beta (CEBPB) Literature-reported Target Interacting Protein Info
UniProt ID
CEBPB_HUMAN 
Synonyms Transcription factor CCAAT/enhancer-binding protein beta; Transcription factor 5; TCF-5; TCF5; PP9092; Nuclear factor NF-IL6; Liver-enriched inhibitory protein; Liver activator protein; LIP; LAP; CCAAT/enhancer-binding protein beta; C/EBP beta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [107]
2 Co-localization [109]
3 Reconstituted Complex [119]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [120]
2 Reconstituted Complex [121]
Interacting Target Name Metastasis associated gene-1 (MTA1) Literature-reported Target Interacting Protein Info
UniProt ID
MTA1_HUMAN 
Synonyms Metastasis-associated protein MTA1; Metastasisassociated protein MTA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [122]
2 Reconstituted Complex [122]
Interacting Protein Name Myb-binding protein 1A (MYBBP1A) Interacting Protein Interacting Protein Info
UniProt ID
MBB1A_HUMAN 
Synonyms P160; PAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [123]
2 Affinity Capture-Western [124]
3 Reconstituted Complex [123]
4 Reconstituted Complex [99]
5 Reconstituted Complex [125]
6 Yeast two hybrid [125]
Other proteins [+] 21 Other proteins +
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Reconstituted Complex [4]
Interacting Protein Name Nuclear receptor-interacting protein 1 (NRIP1) Interacting Protein Interacting Protein Info
UniProt ID
NRIP1_HUMAN 
Synonyms RIP140
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Reconstituted Complex [126]
3 Reconstituted Complex [127]
4 Reconstituted Complex [128]
Interacting Protein Name Prohibitin-2 (PHB2) Interacting Protein Interacting Protein Info
UniProt ID
PHB2_HUMAN 
Synonyms BAP; BCAP37; Bap37; PNAS.141; REA; p22
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [62]
2 Affinity Capture-Western [129]
3 Co-localization [64]
4 Yeast two hybrid [130]
Interacting Target Name Gelsolin (GSN) Literature-reported Target Interacting Protein Info
UniProt ID
GELS_HUMAN 
Synonyms GSN; Brevin; AGEL; Actindepolymerizing factor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [124]
2 Reconstituted Complex [131]
3 Reconstituted Complex [132]
Interacting Protein Name Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) Interacting Protein Interacting Protein Info
UniProt ID
ASH2L_HUMAN 
Synonyms ASH2; ASH2L1; ASH2L2; Bre2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
Interacting Protein Name BAG family molecular chaperone regulator 1 (BAG1) Interacting Protein Interacting Protein Info
UniProt ID
BAG1_HUMAN 
Synonyms BAG.1; HAP; RAP46
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Affinity Capture-Western [49]
3 Reconstituted Complex [133]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) Interacting Protein Interacting Protein Info
UniProt ID
HNRPQ_HUMAN 
Synonyms GRY.RBP; GRYRBP; HNRNPQ; HNRPQ1; NSAP1; PP68; hnRNP.Q
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [5]
3 Reconstituted Complex [4]
Interacting Protein Name Nuclear receptor coactivator 6 (NCOA6) Interacting Protein Interacting Protein Info
UniProt ID
NCOA6_HUMAN 
Synonyms AIB3; ASC2; NRC; PRIP; RAP250; TRBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [76]
3 Reconstituted Complex [134]
Interacting Protein Name Transcription factor HMX3 (PELP1) Interacting Protein Interacting Protein Info
UniProt ID
PELP1_HUMAN 
Synonyms MNAR; P160
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [135]
3 Protein-peptide [136]
Interacting Protein Name Retinoblastoma-binding protein 5 (RBBP5) Interacting Protein Interacting Protein Info
UniProt ID
RBBP5_HUMAN 
Synonyms RBQ3; SWD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
Interacting Protein Name Translocating chain-associated membrane protein 1 (TRAM1) Interacting Protein Interacting Protein Info
UniProt ID
TRAM1_HUMAN 
Synonyms PNAS8; TRAM; TRAMP
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [13]
2 Yeast two hybrid [105]
3 Yeast two hybrid [13]
Interacting Protein Name Tuberin (TSC2) Interacting Protein Interacting Protein Info
UniProt ID
TSC2_HUMAN 
Synonyms LAM; PPP1R160; TSC4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [137]
2 Reconstituted Complex [137]
3 Reconstituted Complex [138]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [76]
Interacting Target Name Nucleolin (NCL) Clinical trial Target Interacting Protein Info
UniProt ID
NUCL_HUMAN 
Synonyms Protein C23; Nucleolin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Drebrin (DBN1) Interacting Protein Interacting Protein Info
UniProt ID
DREB_HUMAN 
Synonyms D0S117E
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Myosin light polypeptide 6 (MYL6) Interacting Protein Interacting Protein Info
UniProt ID
MYL6_HUMAN 
Synonyms ESMLC; LC17; LC17.GI; LC17.NM; LC17A; LC17B; MLC.3; MLC1SM; MLC3NM; MLC3SM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) Interacting Protein Interacting Protein Info
UniProt ID
ROA1_HUMAN 
Synonyms Single-strand RNA-binding protein; HNRPA1; hnRNP core protein A1; hnRNP A1; Heterogeneous nuclear ribonucleoprotein A1; Helix-destabilizing protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) Interacting Protein Interacting Protein Info
UniProt ID
ROA2_HUMAN 
Synonyms HNRPA2B1; hnRNP A2/B1; Heterogeneous nuclear ribonucleoproteins A2/B1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name T-complex protein 1 subunit beta (CCT2) Interacting Protein Interacting Protein Info
UniProt ID
TCPB_HUMAN 
Synonyms 99D8.1; CCT.beta; CCTB; HEL.S.100n; PRO1633; TCP.1.beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [4]
Interacting Protein Name THO complex subunit 4 (ALYREF) Interacting Protein Interacting Protein Info
UniProt ID
THOC4_HUMAN 
Synonyms ALY; ALY/REF; BEF; REF; THOC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [4]
References
REF 1 Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei. Mol Cell Proteomics. 2010 Jun;9(6):1352-67.
REF 2 Identification of proteins associated with ligand-activated estrogen receptor in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Proteomics. 2011 Jan;11(1):172-9.
REF 3 Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. J Biol Chem. 2003 Jul 18;278(29):26704-14.
REF 4 Proteomics analysis of the estrogen receptor alpha receptosome. Mol Cell Proteomics. 2010 Jul;9(7):1411-22.
REF 5 The Dual Estrogen Receptor Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol. 2016 Jan;89(1):14-26.
REF 6 The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 1997 Jun 12;387(6634):677-84.
REF 7 Hakai acts as a coregulator of estrogen receptor alpha in breast cancer cells. Cancer Sci. 2010 Sep;101(9):2019-25.
REF 8 Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain. J Biol Chem. 1998 Oct 23;273(43):28371-7.
REF 9 Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4363-8.
REF 10 Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells. Mol Endocrinol. 2003 Apr;17(4):589-99.
REF 11 Ligands specify coactivator nuclear receptor (NR) box affinity for estrogen receptor subtypes. Mol Endocrinol. 2001 Jun;15(6):909-22.
REF 12 A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. 1997 Jun 12;387(6634):733-6.
REF 13 Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology. 2000 Oct;141(10):3534-45.
REF 14 The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2642-7.
REF 15 Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1. Mol Cell Biol. 2001 Jan;21(1):39-50.
REF 16 Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Mol Cell Biol. 1999 Sep;19(9):6323-32.
REF 17 Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Mol Endocrinol. 2003 Jul;17(7):1296-314.
REF 18 BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Mol Cell Biol. 2000 Oct;20(20):7541-9.
REF 19 Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J. 1998 Jan 2;17(1):232-43.
REF 20 Estrogen receptor activation function 1 works by binding p160 coactivator proteins. Mol Endocrinol. 1998 Oct;12(10):1605-18.
REF 21 Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: correlations with DNA and coregulator int... Mol Endocrinol. 1997 Aug;11(9):1375-86.
REF 22 Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004 Sep 24;15(6):937-49.
REF 23 Condensin I and II Complexes License Full Estrogen Receptor -Dependent Enhancer Activation. Mol Cell. 2015 Jul 16;59(2):188-202.
REF 24 Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12536-40.
REF 25 Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms. Mol Cancer Ther. 2008 Jul;7(7):2096-108.
REF 26 Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor. Mol Endocrinol. 2010 Jun;24(6):1187-202.
REF 27 Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma. Cancer Res. 2009 Jun 15;69(12):5186-93.
REF 28 Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation. Mol Cell Biol. 2007 Oct;27(19):6913-32.
REF 29 TNF-alpha enhances estrogen-induced cell proliferation of estrogen-dependent breast tumor cells through a complex containing nuclear factor-kappa B. Oncogene. 2006 Mar 2;25(9):1367-77.
REF 30 Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 7;67(5):733-743.e4.
REF 31 Amphipathic benzenes are designed inhibitors of the estrogen receptor alpha/steroid receptor coactivator interaction. ACS Chem Biol. 2008 May 16;3(5):282-6.
REF 32 Structure of a biologically active estrogen receptor-coactivator complex on DNA. Mol Cell. 2015 Mar 19;57(6):1047-1058.
REF 33 Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions. J Biol Chem. 2001 Jul 27;276(30):27907-12.
REF 34 p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res. 2002 Jan 1;62(1):141-51.
REF 35 BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha. Mol Endocrinol. 2010 Jan;24(1):76-90.
REF 36 Estrogen receptor (ER) beta or p53 attenuates ERalpha-mediated transcriptional activation on the BRCA2 promoter. J Biol Chem. 2008 Oct 31;283(44):29671-80.
REF 37 Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. Mol Endocrinol. 2006 Sep;20(9):2020-35.
REF 38 BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells. Exp Cell Res. 2006 Oct 1;312(16):3120-31.
REF 39 Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1. Int J Biochem Cell Biol. 2010 May;42(5):693-700.
REF 40 Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene. 2001 Jan 4;20(1):77-87.
REF 41 Structural determinants of the BRCA1 : estrogen receptor interaction. Oncogene. 2005 Mar 10;24(11):1831-46.
REF 42 Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. Mol Endocrinol. 2007 Aug;21(8):1905-23.
REF 43 Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. Oncogene. 2002 Oct 31;21(50):7730-9.
REF 44 Elevated estrogen receptor- in VHL-deficient condition induces microtubule organizing center amplification via disruption of BRCA1/Rad51 interaction. Neoplasia. 2014 Dec;16(12):1070-81.
REF 45 Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. Cancer Res. 2005 Aug 1;65(15):6557-67.
REF 46 Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER) and Biochemical Characterization of the ER-Hsp70 Interaction. PLoS One. 2016 Aug 2;11(8):e0160312.
REF 47 CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Mol Endocrinol. 2005 Dec;19(12):2901-14.
REF 48 Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. EMBO J. 2004 Dec 8;23(24):4813-23.
REF 49 Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Mol Endocrinol. 2008 Jul;22(7):1535-51.
REF 50 Estrogen receptor-, RBCK1, and protein kinase C 1 cooperate to regulate estrogen receptor- gene expression. J Mol Endocrinol. 2012 Oct 30;49(3):277-87.
REF 51 Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen. Oncogene. 2014 Jun 26;33(26):3441-50.
REF 52 Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 1996 Jan 2;15(1):110-24.
REF 53 Liganded ER Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation. Mol Endocrinol. 2015 Nov;29(11):1646-57.
REF 54 Targeting of the adaptor protein Tab2 as a novel approach to revert tamoxifen resistance in breast cancer cells. Oncogene. 2012 Oct 4;31(40):4353-61.
REF 55 Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell. 2006 Feb 10;124(3):615-29.
REF 56 A Novel Functional Domain of Tab2 Involved in the Interaction with Estrogen Receptor Alpha in Breast Cancer Cells. PLoS One. 2016 Dec 19;11(12):e0168639.
REF 57 Ligand-independent activation of oestrogen receptor alpha by caveolin-1. Biochem J. 2001 Oct 1;359(Pt 1):203-10.
REF 58 Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor- interactions with G protein-i and caveolin I. Steroids. 2012 Apr;77(5):424-32.
REF 59 Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. J Biol Chem. 2006 Jun 9;281(23):15714-20.
REF 60 Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7541-6.
REF 61 The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression. Mol Cell Endocrinol. 2008 Sep 10;291(1-2):79-86.
REF 62 Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004 Jun 4;279(23):24834-43.
REF 63 ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cyc... J Biol Chem. 2005 Feb 4;280(5):3185-96.
REF 64 Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells. Nat Commun. 2013;4:2443.
REF 65 Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. Int J Cancer. 2003 Nov 10;107(3):353-8.
REF 66 Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha. Mol Endocrinol. 2005 Dec;19(12):2930-42.
REF 67 Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor. Circ Res. 2010 Jan 8;106(1):155-65.
REF 68 CDK-independent activation of estrogen receptor by cyclin D1. Cell. 1997 Feb 7;88(3):405-15.
REF 69 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 70 Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol Cell Endocrinol. 2002 Feb 25;188(1-2):47-54.
REF 71 Differential requirements of Hsp90 and DNA for the formation of estrogen receptor homodimers and heterodimers. J Biol Chem. 2010 May 21;285(21):16125-34.
REF 72 Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells. J Cell Biochem. 2011 Sep;112(9):2279-86.
REF 73 A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. Cell Stress Chaperones. 1996 Dec;1(4):237-50.
REF 74 Analysis of estrogen receptor alpha signaling complex at the plasma membrane. FEBS Lett. 2004 Nov 19;577(3):339-44.
REF 75 Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells. Proteomics. 2013 Jul;13(14):2100-12.
REF 76 A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science. 2006 Jun 23;312(5781):1798-802.
REF 77 Coactivator-mediated estrogen response in human squamous cell carcinoma lines. J Endocrinol. 2007 Apr;193(1):147-55.
REF 78 p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci. 2004 Mar 15;117(Pt 8):1603-11.
REF 79 PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1. EMBO J. 2007 Aug 8;26(15):3534-44.
REF 80 The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. EMBO J. 2006 Sep 20;25(18):4223-33.
REF 81 Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. Genomics. 2000 Oct 1;69(1):63-71.
REF 82 Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic ce... J Endocrinol. 2003 Mar;176(3):349-57.
REF 83 Binding of the ER and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-related transcription. J Cell Sci. 2012 Apr 15;125(Pt 8):2004-16.
REF 84 P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res. 2006 Feb 1;66(3):1694-701.
REF 85 P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO J. 2002 Oct 15;21(20):5437-47.
REF 86 A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360.
REF 87 Epidermal growth factor directs sex-specific steroid signaling through Src activation. J Biol Chem. 2007 Apr 6;282(14):10697-706.
REF 88 Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. J Biol Chem. 2000 Jul 7;275(27):20928-34.
REF 89 The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha. Br J Cancer. 2005 Jun 20;92(12):2286-91.
REF 90 The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin. Mol Endocrinol. 2008 Feb;22(2):304-16.
REF 91 Quantitative mapping of RNA-mediated nuclear estrogen receptor interactome in human breast cancer cells. Sci Data. 2018 Mar 6;5:180031.
REF 92 The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro. Biochem Biophys Res Commun. 1998 Feb 4;243(1):122-6.
REF 93 Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2. J Cell Physiol. 2009 Dec;221(3):771-7.
REF 94 A large set of estrogen receptor -interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics. 2011 Jan;11(1):159-65.
REF 95 Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2836-9.
REF 96 PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science. 2017 Mar 24;355(6331):1324-1330.
REF 97 Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell. 2008 May 9;30(3):336-47.
REF 98 Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. Int J Biochem Cell Biol. 2016 Jan;70:105-17.
REF 99 Estrogen receptor protects p53 from deactivation by human double minute-2. Cancer Res. 2000 Apr 1;60(7):1810-4.
REF 100 Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 2008 Sep;149(9):4336-45.
REF 101 Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha. J Biol Chem. 2002 Jun 14;277(24):21862-8.
REF 102 MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol. 2005 Feb;25(3):988-1002.
REF 103 The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998 Jan 15;17(2):507-19.
REF 104 Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Biochem Biophys Res Commun. 2009 Jul 24;385(2):263-8.
REF 105 Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs. Mol Cell Biol. 2003 Mar;23(6):2135-50.
REF 106 Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment. J Mol Endocrinol. 2004 Feb;32(1):307-23.
REF 107 A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. J Biol Chem. 2006 Jul 7;281(27):18825-36.
REF 108 Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell. 2005 Sep;16(9):4073-83.
REF 109 Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. J Biol Chem. 2009 Oct 16;284(42):28607-15.
REF 110 Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes. Nucleic Acids Res. 1998 Jun 15;26(12):3044-52.
REF 111 Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature. 2007 Mar 29;446(7135):562-6.
REF 112 Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells. Oncogene. 2012 Nov 15;31(46):4868-77.
REF 113 Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family. J Biol Chem. 2001 Sep 7;276(36):33554-60.
REF 114 Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature. Mol Pharmacol. 2006 May;69(5):1615-23.
REF 115 CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor. Mol Endocrinol. 2008 Feb;22(2):263-72.
REF 116 Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol. 1997 Jun;11(6):657-66.
REF 117 Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells. Mol Endocrinol. 2005 May;19(5):1191-9.
REF 118 Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7821-6.
REF 119 Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol. 1995 Sep;15(9):4971-9.
REF 120 Estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene. J Biol Chem. 2007 Apr 20;282(16):11732-41.
REF 121 Characterization of the physical interaction between estrogen receptor alpha and JUN proteins. J Biol Chem. 2001 Sep 28;276(39):36361-9.
REF 122 A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature. 2002 Aug 8;418(6898):654-7.
REF 123 Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents. Cancer Res. 2007 Jun 1;67(11):5513-21.
REF 124 Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression. Mol Cell Biol. 2003 Aug;23(16):5867-81.
REF 125 MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells. Biochem Biophys Res Commun. 2001 Feb 16;281(1):259-65.
REF 126 Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J. 1995 Aug 1;14(15):3741-51.
REF 127 RIP-140 interacts with multiple nuclear receptors by means of two distinct sites. Mol Cell Biol. 1996 Nov;16(11):6029-36.
REF 128 Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Mol Endocrinol. 2006 May;20(5):1035-47.
REF 129 BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells. PLoS One. 2015 Jun 8;10(6):e0127707.
REF 130 Modulation of estrogen receptor activity by selective coregulators. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):117-22.
REF 131 p21WAF1/CIP1 selectively controls the transcriptional activity of estrogen receptor alpha. Mol Cell Biol. 2005 Mar;25(6):2419-30.
REF 132 Unliganded estrogen receptor alpha inhibits breast cancer cell growth through interaction with a cyclin-dependent kinase inhibitor (p21(WAF1)). FASEB J. 2008 Mar;22(3):671-81.
REF 133 A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11465-9.
REF 134 Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol. 2002 Jan;16(1):128-40.
REF 135 Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. J Biol Chem. 2001 Oct 12;276(41):38272-9.
REF 136 Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. Mol Endocrinol. 2004 May;18(5):1096-108.
REF 137 Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2. J Biol Chem. 2004 May 28;279(22):23114-22.
REF 138 Cross-talk between tuberin, calmodulin, and estrogen signaling pathways. FASEB J. 2005 Jul;19(9):1202-4.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.