Content Navigation
( All
None )
Target General Information |
Top |
Target ID |
T91023 |
Target Info
|
Target Name |
Roof plate-specific spondin-1 (RSPO1) |
Synonyms |
hRspo1; R-spondin-1 |
Target Type |
Clinical trial Target |
Gene Name |
RSPO1 |
UniProt ID |
|
Target Interacting Proteins |
Top |
Acyltransferases |
[+] 1 Acyltransferases |
+ |
Interacting Protein Name |
E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) |
Interacting Protein |
Interacting Protein Info
|
UniProt ID |
|
Synonyms |
BK747E2.3; RNF203 |
Evidence Score (E-score) |
2 Experimental Evidences |
+ |
1 |
Fluorescence Resonance Energy Transfer |
[1] |
2 |
Reconstituted Complex |
[2] |
G-protein-coupled receptors |
[+] 1 G-protein-coupled receptors |
+ |
Interacting Protein Name |
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) |
Interacting Protein |
Interacting Protein Info
|
UniProt ID |
|
Synonyms |
BNMD17; GPR48 |
Evidence Score (E-score) |
3 Experimental Evidences |
+ |
1 |
Affinity Capture-Western |
[3] |
2 |
Fluorescence Resonance Energy Transfer |
[1] |
3 |
Reconstituted Complex |
[2] |
References |
Top |
REF 1 |
Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli. Biochemistry. 2013 Oct 15;52(41):7295-304.
|
REF 2 |
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin. EMBO Rep. 2013 Dec;14(12):1120-6.
|
REF 3 |
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013;4:2787.
|
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.