Target Validation Information
TTD ID	T00176
Target Name	Ubiquitin-protein ligase E3 Mdm2 (MDM2)
Type of Target	Clinical trial
Action against Disease Model	RG7112	Drug Info	Targeted inhibition of the p53-MDM2 interaction by nutlin-3 decreased the viability of UKF-NB-3 cells in a dose- and time-dependent manner, with IC50 values in the low micromolar range (2.03 uM ~ 3.62 uM).	[1]
References
REF 1	Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53. J Natl Cancer Inst. 2009 Nov 18;101(22):1562-74.

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